Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials

Effect of resistance training volume on body adiposity, metabolic risk, and inflammation in postmenopausal and older females: Systematic review and meta-analysis of randomized controlled trials

“… 97 , 98 , 99 , 100 Interestingly, RT volume has been shown to be positively associated with the activation of signaling pathways that regulate aerobic capacity (e.g., mitochondrial biogenesis, glucose, and fatty acid oxidation), myokine secretion (e.g., IL-6, follistatin), and anti-inflammatory and metabolic balance (e.g., insulin sensitivity, adipose tissue browning, and optimizing of the status of metabolic diseases). 92 , 101 , 102 , 103 Our results suggest that HVRT may be associated with better responses to metabolic risk and inflammation, particularly in postmenopausal and older females.…”

Body Adiposity Partially Mediates the Association between FTO rs9939609 and Lower Adiponectin Levels in Chilean Children

“…Recent research shows that adherence to a Mediterranean dietary pattern, higher intake of unsaturated fatty acids, whole grains, polyphenols and probiotics improves the inflammatory biomarker profile, including the elevation of plasma adiponectin [ 55 , 56 ]. Moreover, it is well known that physical exercise triggers a number of signaling pathways stimulating the production of the bioactive molecules, adiponectin among them, that exert beneficial health effects [ 57 ]. A study reported that among individuals with the lowest physical activity levels, those carrying the A allele at rs9939609 had lower plasma adiponectin concentrations as compared to carriers of the TT genotype [ 21 ].…”

Considerations for exerkine research focusing on the response to exercise training

“… 4 , 5 IL-6 is also released from contracting skeletal muscle during acute exercise, with resultant effects including potentiating insulin secretion and action, enhancing glucose uptake, and increasing fat oxidation. 6 In contrast to acute exercise where circulating IL-6 concentrations increase, García-Hermoso and colleagues’ analysis 1 found that circulating IL-6 concentrations decrease at rest in response to exercise training . In fact, the exercise training-induced decreases in resting IL-6 concentrations were positively correlated with a decrease in hemoglobin A1c ( β = 0.44, p = 0.012).…”

“… 10 Circulating concentration of fetuin-A is transiently elevated by a single bout of exercise before returning to baseline after 24 h, 11 yet is decreased in response to exercise training. 1 …”

“…García-Hermoso and colleagues 1 recently published a systematic literature review and meta-analysis on exercise training-induced changes in exerkine concentrations in type 2 diabetes mellitus patients, providing a contemporary view on how exerkines respond to exercise training. That review prompted us to highlight 2 additional considerations that should be taken into account when studying the response of exerkines to exercise training.…”