Exercise ventilation correlates positively with ventilatory chemoresponsiveness

Martin, Bradley J.; Weil, John V.; Sparks, Kenneth E.; McCullough, R. E.; Grover, R. F.

doi:10.1152/jappl.1978.45.4.557

Cited by 96 publications

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“…The group-by-time interaction was tested. Because the hypoxic ventilatory response correlates to the body surface area, 2,20,21 changes in ventilation in response to hypoxia were normalized for body surface area and related to the ventilatory response to exercise (characterized by the regression slope relating ventilation to CO 2 output during exercise, V E/V CO 2 slope) through linear regression analysis. 11 Responses to hypercapnia were compared by a Mann-Whitney test.…”

Section: Discussionmentioning

confidence: 99%

“…1 Peripheral chemoreceptors also play an important modulatory role in the regulation of ventilation during exercise. [2][3][4][5] This is evidenced by the observation that breathing oxygen decreases ventilation and increases arterial carbon dioxide to a greater extent during exercise than at rest. 6,7 Central chemoreceptors are located in the brain stem and respond primarily to hypercapnia.…”

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confidence: 99%

“…9 In normal subjects and athletes, there is a positive relation between V E and the rate of CO 2 production (V CO 2 ) during exercise and central chemoreceptor sensitivity at rest. 2,5,10 Heart failure is accompanied by increased peripheral and central chemosensitivity, 11,12 which correlates with an in-…”

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Increased Peripheral Chemoreceptors Sensitivity and Exercise Ventilation in Heart Transplant Recipients

et al. 2006

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Background-Heart failure is characterized by increased ventilation during exercise, which is positively related to increased peripheral and central chemoreceptor sensitivity. Heart transplantation does not normalize the ventilatory response to exercise, and its effects on the chemoreflex control of ventilation remain unknown. We tested the hypothesis that chemoreceptor sensitivity is increased in heart transplant recipients (HTRs) and linked to exercise hyperpnea. Methods and Results-We determined the ventilatory, muscle sympathetic nerve activity (MSNA), and circulatory responses to isocapnic hypoxia and hyperoxic hypercapnia 7Ϯ1 years after transplantation in 19 HTRs with a normal left ventricular ejection fraction of 60Ϯ2%. Results were compared with those of 11 closely matched referent subjects. Sixteen patients and 10 referent subjects also underwent cycle ergometer exercise tests. HTRs compared with referent subjects presented higher MSNA (52Ϯ4 versus 34Ϯ3 bursts/min; PϽ0.01) and heart rates (83Ϯ3 versus 68Ϯ3 bpm; PϽ0.01) during room air breathing. The ventilatory response to hypoxia was higher in HTRs than in referent subjects (PϽ0.01, ANOVA). The increase in MSNA also was more marked during hypoxia in the HTRs than in the referent group (PϽ0.05, ANOVA

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Section: Discussionmentioning

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Increased Peripheral Chemoreceptors Sensitivity and Exercise Ventilation in Heart Transplant Recipients

et al. 2006

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“…In addition to the obesity factor described above, numerous other factors Vol.32, No.4, 1982 Y. OHYABU, A. YOSHIDA, F. HAYASHI, N. SATO, and Y. HONDA have been reported to affect hypoxic sensitivity : altitude exposure (MILLEDGE and LAHIRI, 1967;WEIL et al, 1971a), athleticism (BYRNE-QUINN et al, 1971;MARTIN et al, 1978), hyperthermia (NATALINO, 1977), mixed venous PCO2, level (REBUCK and WOODLEY, 1975), malnutrition (DAEKEL, 1976), aging (KRONENBERG and DRAGE, 1973, familial or genetic factor (COLLINS et al, 1978 ;KAWAKAMI et al, 1981a ;KAWAKAMI et al, 1981b), congenital cyanotic heart disease (SORENSEN and SEVERINGHAUS, 1968 ;BLESA et al, 1977), various drugs, anesthesia or sedation (HIRSHMAN et al, 1975a ;HIRSHMAN et al, 1975b ;YACOUB et al, 1976;HIRSHMAN et al, 1977;KNILL and GELB, 1978;LAKSHMINARAYAN et al, 1978 ;SANDERS et al, 1980), and alveolar hypoventilation syndromes (SHANNON and KELLY, 1977 ;BRADLEY et al, 1979 ;SCHIFFMAN et al, 1980;BERMAN et al, 1981 ;HUNT et al, 1981). None of the above factors, however, seems to satisfactorily explain the results obtained in the present study.…”

Section: Discussionmentioning

confidence: 99%

High ventilatory response to hypoxia observed in obese judo athletes.

et al. 1982

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Fifty-two active Judo athletes were examined using an isocapnic progressive hypoxia test. The results were analyzed by the hyperbola ventilation equation V= Vo H-A/(PETO2-C), where Vis observed ventilation, Vo the horizontal asymptote in ventilation for infinite end-tidal Po 2(PETO2), A the slope constant indicating magnitude of hypoxic sensitivity, and C the vertical asymptote in PETo2 for infinite ventilation. Hypoxic sensitivity, A, was positively correlated with body weight (BW). Such correlation in the light and middleweight groups (BW<95 kg) and the heavyweight group (BW>95 kg) with Rohrer's index being less than 200 became insignificant when the A value was recalculated after normalization of ventilation for 70 kg body mass. However, the heavyweight group with a Rohrer index of higher than 200 still exhibited a significantly higher A value than the light and middleweight groups after normalization of ventilation. These results indicated that body weight plus obesity were determining factors in the increase of hypoxic sensitivity in our subjects.

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“…Peripheral chemosensitivity was assessed by hypoxic ventilatory responsiveness (HVR) and central chemosensitivity by hypercapnic ventilatory responsiveness (HCVR), both at rest. Since it has been reported that HVR [10][11][12] and HCVR [13] increase with increasing exercise intensity, and that the exercise estimates of HVR depend on the resting estimates of HVR [11,12,14], the individual differences in exercise estimates of chemosensitivities at varying work rates were assumed to be predicted from those in the resting estimates.…”

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Respiratory Compensation Point during Incremental Exercise as Related to Hypoxic Ventilatory Chemosensitivity and Lactate Increase in Man.

Takano

2000

JJP

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During incremental exercise in normal humans, pulmonary ventilation (V E) linearly increases with increasing O 2 uptake (V O 2 ), but the increment of V E against V O 2 becomes steeper at two V O 2 points [1]. The first inflection point, occurring at a lower V O 2 , is termed the ventilatory threshold (VT) [2], above which various kinds of ventilatory stimuli such as a fall in arterial pH due to lactic acidosis, hyperkalemia and augumentation of arterial PCO 2 oscillation are newly induced [3][4][5][6]. With further increases in the ventilatory stimuli as exercise becomes heavier, a steeper increase in V E against V O 2 occurs. The V O 2 point of the onset of this V E augmentation is termed the respiratory compensation point (RCP), above which the V E augmentation (hyperventilation) induces a fall in arterial PCO 2 , with resulting constraint of further falls of arterial pH due to severer lactic acidosis [7]. Peripheral chemoreceptors have been implicated as the site at which the ventilatory stimuli act because of the absence of compensatory hyperventilation and subsequent fall in PCO 2 during heavy exercise in carotid body-resected patients [8,9]. Japanese Journal of Physiology, 50, 449-455, 2000 Key words: heavy exercise, respiratory compensation point, exercise hyperpnea, carotid body, lactic acidosis. Abstract:The pulmonary ventilation-O 2 uptake (V E-V O 2 ) relationship during incremental exercise has two inflection points: one at a lower V O 2 , termed the ventilatory threshold (VT); and another at a higher V O 2 , the respiratory compensation point (RCP). The individuality of RCP was studied in relation to those of the chemosensitivities of the central and peripheral chemoreceptors, which were assessed by resting estimates of hypercapnic ventilatory response (HCVR) and hypoxic ventilatory response (HVR), respectively, and the rate of lactic acid increase during exercise, which was estimated as a slope difference (⌬slope) between a lower slope of V CO 2 -V O 2 relationship (V CO 2 : CO 2 output) obtained at work rates below VT and a higher slope at work rates between VT and RCP. Twenty-two male and sixteen female subjects underwent a 1 min incremental exercise test until exhaustion, in which VT, RCP and ⌬slope were determined. All measures were normalized for body surface area. In the males, the individual difference in RCP was inversely correlated with those of HVR and ⌬slope (pϽ0.05), and in the females, similar tendencies persisted, while the correlation did not reach statistically significant levels (0.05ϽpϽ 0.1). There was no significant correlation between RCP and HCVR in either sex. A multiple linear regression analysis showed that 40 to 50% of the variance of RCP was accounted for by those of HVR and ⌬slope, both of which were related linearly and additively to RCP, this relation being manifested in the males but not in the females without consideration of the menstrual cycle. These results suggest that the individuality of RCP depends partly on the chemosensitivity of the carotid bodies and th...

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Exercise ventilation correlates positively with ventilatory chemoresponsiveness

Cited by 96 publications

References 0 publications

Increased Peripheral Chemoreceptors Sensitivity and Exercise Ventilation in Heart Transplant Recipients

Increased Peripheral Chemoreceptors Sensitivity and Exercise Ventilation in Heart Transplant Recipients

High ventilatory response to hypoxia observed in obese judo athletes.

Respiratory Compensation Point during Incremental Exercise as Related to Hypoxic Ventilatory Chemosensitivity and Lactate Increase in Man.

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