This meta‐analysis aimed to synthesize the effects of virtual reality‐based exercise on physical function, depression symptoms and quality of life in adults receiving haemodialysis. Data were analysed using Comprehensive Meta‐Analysis Version 3. The random‐effects meta‐analysis was performed to pool intervention effects. A total of five studies were included. The majority of included studies compared intervention with passive control group. This meta‐analysis showed with a moderate to high quality of evidence that virtual reality‐based exercise has positive medium effect on improving physical function such as gait speed (g = .40, 95% CI 0.00 to 0.81), sit to stand 10 times (g = −.41, 95% CI −0.825 to −0.009), sit to stand in 60 s (g = .56, 95% CI 0.151 to 0.974), 6‐min walk test (g = .66, 95% CI 0.247 to 1.079), not affect time up and go and sit to stand five times. The study indicated with moderate quality of evidence that virtual reality‐based exercise had no effect on depression symptoms. The study also showed with a moderate quality of evidence that the intervention had a positive medium effect on improving physical function (g = .64, 95% CI 0.20 to 1.09). In conclusion, virtual reality‐based exercise can be performed to improve physical function and quality of life of adults receiving haemodialysis for health professionals.