Exfoliated cells and in vitro growth in colorectal cancer

Skipper, D.; Cooper, Alan; Marston, J; Taylor, I.

doi:10.1002/bjs.1800741130

Cited by 133 publications

(60 citation statements)

References 19 publications

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“…Previous studies have shown that surgery for bowel obstruction and tumor perforation during surgery is a risk factor for recurrence and reduced 5 year sur- Cancer cells with the ability to grow have been demonstrated after colorectal cancer resections from luminal mucosa, rectal stump, serosal surface washings and post-dissection lavage tumor bed [37]. This was not supported in the present multivariate model.…”

Section: Discussioncontrasting

confidence: 62%

Clinical Predictors for Recurrence after Curative Resection for Colorectal Cancer

Røkke¹,

Heggelund²,

Benth³

et al. 2017

JCT

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Purpose: To identify clinical predictors of recurrence of colorectal cancer after curative surgical treatment. Methods: Retrospective follow-up-study of 925 consecutive patients treated with R0-resection for colorectal cancer Stage I, II and III from 1990 until 2000 with a mean follow-up of 60 ± 37 months. Predictors for cancer recurrence were identified in a pilot-sample of these patients, followed by analyses of the rest of the patients (test-sample), and finally with a concluding analyses of the entire patient group. Data were analyzed with Pearson Chi-square test (χ 2 ), Cox regression analyses and log rank test. Results: Tumor stage (Stage I: HR 0.10 (0.05; 0.19), Stage II: HR 0.31 (0.24; 0.41)) and postoperative reoperations due to complications due to other causes than anastomotic leakage (HR 2.02 (1.21; 3.36)) were significant predictors of cancer recurrence in the multivariate Cox regression model. The association between reoperations and recurrence was strongest for the patients with the best prognosis: Stage I and Stage II-cancers. Long duration of surgery, strongly associated with blood-loss and infusions of liquid and blood-products, reoperation due to anastomotic leakage as well as right colon/transversum localization were significant at a trend-level (10%). Conclusions: Tumor stage and reoperations due to postoperative complications other than anastomotic leakage are significant predictors for recurrence after curative surgery for colorectal cancer.

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Section: Discussioncontrasting

confidence: 62%

Clinical Predictors for Recurrence after Curative Resection for Colorectal Cancer

Røkke¹,

Heggelund²,

Benth³

et al. 2017

JCT

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“…[71][72][73][74] Experimentally-induced anastomotic implantation of luminal cells has been demonstrated in an animal model. 79 Cases of implantation metastases in anal wounds from occult proximal tumours have been reported.…”

Section: -78mentioning

confidence: 99%

Comparing colorectal cancer treatment and survival for Aboriginal and non‐Aboriginal people in New South Wales

Weir

Supramaniam

Gibberd

et al. 2016

Medical Journal of Australia

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Objectives: Our aim was to compare surgical treatment rates and survival rates for Aboriginal and non‐Aboriginal people in New South Wales with colorectal cancer, and to describe the medical treatment received by a sample of Aboriginal people with colorectal cancer. Design, setting and participants: All people diagnosed with colorectal cancer in NSW during 2001–2007 were identified and their cancer registry records linked to hospital admissions data and death records. A medical records audit of a sample of Aboriginal people diagnosed with colorectal cancer during 2000–2011 was also conducted. Main outcome measures: Cause‐specific survival, odds of surgical treatment, and the proportions of people receiving adjuvant treatments. Results: Of 29 777 eligible colorectal cancer cases, 278 (0.9%) involved Aboriginal people. Similar proportions of Aboriginal (76%) and non‐Aboriginal (79%) people had undergone surgical treatment. Colorectal cancer‐specific survival was similar for Aboriginal and non‐Aboriginal people up to 18 months after diagnosis, but 5 years post‐diagnosis the risk of death for Aboriginal people who had had surgical treatment was 68% higher than for non‐Aboriginal people (adjusted hazards ratio, 1.68; 95% CI, 1.32–2.09). Of 145 Aboriginal people with colorectal cancer identified by the medical records audit, 117 (81%) had undergone surgery, and 56 (48%) had also received adjuvant chemotherapy and/or radiotherapy. Conclusions: Aboriginal people with colorectal cancer had poorer survival rates than non‐Aboriginal people, although rates of surgical treatment, complications and follow‐up colonoscopy were similar. More work is needed to identify and understand why outcomes for Aboriginal people with colorectal cancer are different from those of other New South Wales residents.

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“…Suture-line recurrence in the jejunal pouch is extremely rare. Possible underlying mechanisms include submucosal or subserosal lymphatic spread of cancer, and the implantation of exfoliated cancer cells [5,6]. In our patient, lymphatic spread was unlikely to have been the route of recurrence, because the histology of the primary tumor was differentiated type and no lymphatic permeation or lymph node metastasis was seen.…”

Section: Discussionmentioning

confidence: 64%

Recurrence of gastric cancer in the jejunal pouch after completion gastrectomy

et al. 2007

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Case reportA 74-year-old man with a history of two operations for gastric cancer was admitted to our hospital in January 2005. The fi rst operation was a distal gastrectomy and Billroth I reconstruction for early gastric cancer, in 1994. Histologically, the tumor was signet-ring cell carcinoma confi ned to the submucosa, and no lymph node metastasis was detected.In January, 2002, an ulcerative tumor, measuring 5.0 × 2.5 cm, was found in the lesser curvature of the subcardia in the remnant stomach, and he underwent a completion gastrectomy with regional lymphadenectomy. Reconstruction was by the Roux-en-Y method, with a jejunal pouch. The pouch was created by a making a side-to-side anastomosis of the jejunal loop with a linear stapler and apical section of unstapled jejunal loop, then an esophagojejunostomy was performed using a circular stapler. Histologically, the tumor was moderately differentiated tubular adenocarcinoma invading the proper muscle layer (T2a), without permeation of the lymphatic or venous capillaries. The cancer-stroma relationship was medullary. The proximal and distal resection margins were free of cancer invasion. No lymph node metastasis was seen (stage IB), and the patient was followed up without adjuvant chemotherapy.In October 2004, a follow-up endoscopy revealed irregularly shaped elevated lesions on the esophagojejunostomy line and along the suture line in the jejunal pouch (Fig. 1). Biopsy showed moderately differentiated tubular adenocarcinoma. Computed tomography showed no lymphadenopathy or hepatic metastasis. The patient's performance status was good, and we decided to perform a third operation with the diagnosis of local recurrence.In January 2005, we performed a transabdominal resection of the lower esophagus and jejunal pouch. There was no evidence of hepatic or peritoneal recur- AbstractWe herein present a case of recurrence of gastric cancer in the jejunal pouch after total gastrectomy in a 74-year-old man. He had a history of two operations for gastric cancer. The second operation was a completion gastrectomy with jejunal pouch reconstruction and regional lymphadenectomy, for gastric cancer in the cardia of the remnant stomach, performed 2 years and 9 months before the present admission. A followup endoscopy showed three elevated tumors along the suture lines in the jejunal pouch in the upper digestive tract. Resection of the jejunal pouch was performed. Gross pathological examination revealed elevated lesions along the staple suture lines in the jejunal pouch. Histopathologically, moderately differentiated tubular adenocarcinoma involving the muscular layer, without lymphatic metastases, was recognized. Recurrence of gastric cancer in the jejunal pouch after resection is rare. We suggest that implantation of exfoliated cancer cells gave rise to the recurrence of tumors on the suture line in this patient. We also review two cases of gastric cancer in the jejunal pouch after resection previously described in the literature.

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Exfoliated cells and in vitro growth in colorectal cancer

Cited by 133 publications

References 19 publications

Clinical Predictors for Recurrence after Curative Resection for Colorectal Cancer

Clinical Predictors for Recurrence after Curative Resection for Colorectal Cancer

Comparing colorectal cancer treatment and survival for Aboriginal and non‐Aboriginal people in New South Wales

Recurrence of gastric cancer in the jejunal pouch after completion gastrectomy

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