Exfoliated graphene nanosheets: pH-sensitive drug carrier and anti-cancer activity

Tyagi, Nisha; Attia, Nour F.; Geckeler, Kurt E.

doi:10.1016/j.jcis.2017.03.057

Cited by 39 publications

(15 citation statements)

References 70 publications

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“…The results of the MTT test also confirm a decrease in cell viability due to the action of graphene oxide. Studies by Tyagi et al [ 30 ] indicate a time-dependence for cells exposed to graphene oxide, where the likely cause of growth inhibition, as they describe, is the lack of access to nutrients caused by the deposition of graphene oxide aggregates on cells. As in the present study, Changa et al [ 31 ] indicate that a significant decrease in cell survival is noticeable at higher concentrations, and Seabra and his team [ 32 ] confirm that cell viability is influenced by concentrations of graphene oxide above 100 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug

et al. 2020

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Drug modification with nanomaterials is a new trend in pharmaceutical studies and shows promising results, especially considering carbon-based solutions. Graphene and its derivatives have attracted much research interest for their potential applications in biomedical areas as drug modifiers. The following work is a comprehensive study regarding the toxicity of ciprofloxacin (CIP) modified by graphene oxide (GO). The influence on the morphology, viability, cell death pathway and proliferation of T24 and 786-0 cells was studied. The results show that ciprofloxacin modified with graphene oxide (CGO) shows the highest increase in cytotoxic potential, especially in the case of T24 cells. We discovered a clear connection between CIP modification with GO and the increase in its apoptotic potential. Our results show that drug modification with carbon-based nanomaterials might be a promising strategy to improve the qualities of existing drugs. Nevertheless, it is important to remember that cytotoxicity effects are highly dependent on dose and nanomaterial size. It is necessary to conduct further research to determine the optimal dose of GO for drug modification.

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Section: Discussionmentioning

confidence: 99%

Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug

et al. 2020

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“…Moreover, a recent study shows that the graphene nanosheet has the dual role as a nanocarrier for the anti-cancer drug, and also acts as an anti-cancer agent [ 15 ]. In the research conducted by Tyagi et al [ 15 ], the graphene nanosheets were exfoliated by using poly(vinylpyrrolidone) nanoparticles (PVP-NP), which have higher concentrations of loaded drug caused significant cytotoxicity against both mouse embryonic fibroblasts (NIH-3T3) and human colorectal cancer cells (HCT-116). As shown in Figure 2 , the toxic effect of graphene-poly(vinylpyrrolidone) nanoparticle composite (GRP-PVP-NP) against cancer cells is visualized.…”

Section: Biomedical Applicationmentioning

confidence: 99%

“… Schematic diagram of potential mechanism with graphene-poly(vinylpyrrolidone) nanoparticle composite (GRP-PVP-NP) induced cytotoxicity in cancer cells [ 15 ]. …”

Section: Figurementioning

confidence: 99%

Mini Review: Nanosheet Technology towards Biomedical Application

2017

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The fabrication technique of ultrathin film (commonly known as nanosheets) has been significantly developed over the years. Due to the mechanical properties of nanosheets, such as high levels of adhesion and flexibility, this made nanosheets the ideal candidate in biomedical applications. In this review, innovative biomedical applications of nanosheets are discussed, which include, drug delivery, wound treatment, and functional nanosheets towards flexible biodevices, etc. Finally, the future outlook of nanosheet technology towards a biomedical application is discussed.

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“…This has been investigated for several polymer nanocomposites and carbon‐based materials for different applications . Furthermore, in one of our recent studies polymer nanoparticles of an average size of 42 nm were used for the exfoliation of graphene sheets and specifically their drug delivery properties were studied …”

Section: Introductionmentioning

confidence: 99%

“…[31,32] Furthermore, in one of our recent studies polymer nanoparticles of an average size of 42 nm were used for the exfoliation of graphene sheets and specifically their drug delivery properties were studied. [33] In this study, graphene sheets were exfoliated by an onepot method using ultrasonication in aqueous solution of the polymer nanoparticles. In addition, poly(vinylpyrrolidone) (PVP) nanoparticles of different sizes have been prepared by using an environmentally friendly method and employed for the graphene exfoliation.…”

Section: Introductionmentioning

confidence: 99%

Exfoliated Graphene Sheets: Polymer Nanoparticles as a Tool and Their Anti‐Proliferative Activity

et al. 2019

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A facile one‐pot and environment‐friendly method has been developed for the synthesis of graphene sheets. Poly(vinylpyrrolidone) nanoparticles with a size range of 23–57 nm are used for the exfoliation process of graphene sheets in conjunction with ultrasonication. The polymer nanoparticle size played a significant role in the exfoliation yield of the graphene sheets. The small nanoparticle size of 23 nm was found to be the most effective size for the exfoliation. Thus, high quality individualized graphene sheets were obtained and the sheet thickness was found to be 4 nm. The polymer nanoparticles contributed to stable graphene dispersions through wrapping on the surface of the sheets. The graphene sheets have been characterized by using Raman and UV‐Vis spectroscopy and their morphology visualized by transmission electron microscopy. In addition, the as‐prepared graphene sheets were investigated as a potential cytotoxic drug and their anti‐proliferative activity was studied in vitro by the MMT assay. The results showed a remarkable lethality rate of 87% for human colon cancer cells (HCT‐116) and biocompatibility to normal mouse embryonic fibroblast NIH‐3T3 cells.

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Exfoliated graphene nanosheets: pH-sensitive drug carrier and anti-cancer activity

Cited by 39 publications

References 70 publications

Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug

Ciprofloxacin and Graphene Oxide Combination—New Face of a Known Drug

Mini Review: Nanosheet Technology towards Biomedical Application

Exfoliated Graphene Sheets: Polymer Nanoparticles as a Tool and Their Anti‐Proliferative Activity

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