Exfoliation syndrome related to sensorineural hearing loss

Papadopoulos, Theodoros-Athanassios; Naxakis, S; M, Charalabopoulou; Vathylakis, Ioannis; Goumas, Panos; Gartaganis, Sotirios P.

doi:10.1111/j.1442-9071.2010.02289.x

Cited by 24 publications

(34 citation statements)

References 28 publications

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“…Papadopoulos et al also pointed out an association between PEX and hearing impairment, but in the high frequency ranges, particularly 8 kHz [21,22]. In objective hearing tests like DPOAE and ABR, Paliobei et al found that patients with PEX showed a greater prevalence of retrocochlear pathology [23].…”

Section: Discussionmentioning

confidence: 99%

“…Perhaps the stiffening of the vibrating basilar membrane of the cochlea is most noticeable for this particular frequency. Another theory is that deposits in vessel walls lead to an impaired blood supply to the inner ear [21]. This hypothesis is justified by the fact that the hair cells responsible for the perception of stimuli in high frequency ranges are the most sensitive to ischemia.…”

Section: Discussionmentioning

confidence: 99%

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Evaluating the Hearing of Patients with Pseudoexfoliation Syndrome

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluating the Hearing of Patients with Pseudoexfoliation Syndrome

et al. 2016

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“…Studies exploring PXF and hearing loss generally support a relationship, but it is not clear whether it is more common in PXF alone or in conjunction with PXF glaucoma 58–62,68–70 . In addition, there is no consensus on whether the hearing loss is generalized or specific to select octave bands.…”

Section: Auditory Systemmentioning

confidence: 99%

“…[64][65][66][67] Studies exploring PXF and hearing loss generally support a relationship, but it is not clear whether it is more common in PXF alone or in conjunction with PXF glaucoma. [58][59][60][61][62][68][69][70] In addition, there is no consensus on whether the hearing loss is generalized or specific to select octave bands. Turacli et al (2007) revealed a higher incidence of hearing loss in individuals with PXF compared with those without PXF.…”

Section: Auditory Systemmentioning

confidence: 99%

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

O’Hare¹,

Rance²,

McKendrick³

et al. 2012

Clinical Exper Ophthalmology

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Open-angle glaucoma is an optic neuropathy that has a multifarious aetiological profile. Emerging theories suggest that a group of factors induce optic nerve injury in innately susceptible aging optic nerves. These factors have the potential to impact on the function of other vulnerable neurons within the central nervous system of older patients. Although changes within the visual pathways due to retinal ganglion cell dysfunction and death are well established, research exploring the behaviour of other sensory systems in individuals with glaucoma is limited. This review summarizes what is known about these other non-visual sensory changes, explores whether glaucoma is in fact part of a global neurodegenerative condition, and suggests areas for future research direction.

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“…; Papadopoulos et al. , ; Paliobei et al. ); yet, most of these studies were not performed in conjunction with otologists, nor do they provide any otopathological correlation.…”

Section: Introductionmentioning

confidence: 99%

Exfoliation syndrome: assembling the puzzle pieces

Pasquale

Borrás

Fingert

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Purpose: To summarize various topics and the cutting edge approaches to refine XFS pathogenesis that were discussed at the 21st annual Glaucoma Foundation Think Tank meeting in New York City, Sept. 19-20, 2014. Methods: The highlights of three categories of talks on cutting edge research in the field were summarized. Results: Exfoliation syndrome (XFS) is a systemic disorder with a substantial ocular burden, including high rates of cataract, cataract surgery complications, glaucoma and retinal vein occlusion. New information about XFS is akin to puzzle pieces that do not quite join together to reveal a clear picture regarding how exfoliation material (XFM) forms. Conclusion: Meeting participants concluded that it is unclear how the mild homocysteinemia seen in XFS might contribute to the disarrayed extracellular aggregates characteristic of this syndrome. Lysyl oxidase-like 1 (LOXL1) variants are unequivocally genetic risk factors for XFS but exactly how these variants contribute to the assembly of exfoliation material (XFM) remains unclear. Variants in a new genomic region, CACNA1A associated with XFS, may alter calcium concentrations at the cell surface and facilitate XFM formation but much more work is needed before we can place this new finding in proper context. It is hoped that various animal model and ex vivo systems will emerge that will allow for proper assembly of the puzzle pieces into a coherent picture of XFS pathogenesis. A clear understanding of XFS pathogenesis may lead to 'upstream solutions' to reduce the ocular morbidity produced by XFS.

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Exfoliation syndrome related to sensorineural hearing loss

Cited by 24 publications

References 28 publications

Evaluating the Hearing of Patients with Pseudoexfoliation Syndrome

Evaluating the Hearing of Patients with Pseudoexfoliation Syndrome

Is primary open‐angle glaucoma part of a generalized sensory neurodegeneration? A review of the evidence

Exfoliation syndrome: assembling the puzzle pieces

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