Exfoliative Cytologic Findings of Primary Pulmonary Adenoid Cystic Carcinoma

Daneshbod, Yahya; Modjtahedi, Ebrahim; Atefi, Sohrab; Bedayat, Gholam Reza; Daneshbod, Khosrow

doi:10.1159/000325794

Cited by 12 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particularly, adenoid cystic carcinoma is known to make gland-like spaces in the clusters (also called globules), cyanophilic hyaline basement membrane material, and ball-like formations, resulting in a sieve-like cell arrangement. [9][10][11][12][13][14] In conclusion, we assume that the clear and amorphous ball-like structures (Fig. 1) in the clusters were entrapped alveolar air spaces associated with strong cellular cohesion in an acinar growth pattern of SRA, and that a sufficient amount of bronchial brushing specimens is as good as transbronchial lung biopsy.…”

Section: A Report Of Two Casesmentioning

confidence: 70%

Bronchial brushing cytology of primary signet‐ring adenocarcinoma of the lung. Another morphological feature on the papanicolaou smear: A report of two cases

Sakai

Ohbayashi

Satouchi

et al. 2010

Diagnostic Cytopathology

View full text Add to dashboard Cite

Primary signet-ring adenocarcinoma of the lung (SRA), categorized as a variant of pulmonary adenocarcinoma in the WHO classification, 1 is a special histolopathologic type of mucin-producing lung cancers. In most cases, signet-ring cells (SRCs) are recognized as one component of the tumor (the pure type is very rare) the other being mostly conventional adenocarcinoma, and infrequently, adenosquamous carcinoma. 2 The group in which the SRC component occupies 50% of the cancer occurs at a younger age and its prognosis is poorer-the 5-year survival rate is 28.4%. 2 Recently, the ALK-rearranged nonsmall cell lung cancers have been implicated in a solid growth pattern with SRCs. 3 Two distinct patterns of growth are recognized in SRA: mainly acinar and occasionally diffuse. 4 The few reports on SRA, from the point of view of cytomorphology on Papanicolaou smears, are probably based on the acinar growth pattern. 5,6 The significant cytological features of SRA are the presence of single SRCs and nuclear pleomorphism, as compared with goblet-cell-type adenocarcinoma. 5 Here, we describe another interesting cytological feature found in bronchial brushing smears of two cases of SRA and confirmed by surgical lung resections.Two Japanese men (a 55-year-old nonsmoker with a 7-year indolent growth (patient 1) and a 53-year-old onepack-a-day smoker (patient 2)), had no symptoms, but computed tomography of the chest revealed a well-demarcated 20 3 17 mm (patient 1) and 23 3 20 mm (patient 2) mass in the left inferior lobe of the lung. Cytology specimens obtained by bronchial brushings against the tumors were fixed in 95% alcohol and subjected to Papanicolaou staining. According to the sixth edition of the UICC TNM classification and the results of systemic examinations, the tumors were cT1N1M0, stage IIA (patient 1) and cT1N0M0, stage IA (patient 2); consequently, both patients underwent left lower lobectomy. No further treatment was given to either patient. Three years thereafter, pleuritis carcinomatosa with left pleural effusion was detected in patient 1 during the follow-up. No signs of local recurrence or distant metastasis were observed in patient 2, 2 years after the lobectomy.Cytologically, both cases showed essentially similar findings. Cytological examination of the smears revealed moderate cellularity and many three-dimensional cell clusters of various sizes in a clear background. The clusters showed strong, mostly well-outlined, and clear overlapping intracellular cohesion and some single cells partly dissociated from the clusters. The uniform round cells in the clusters showed the following signet-ring features: peripheral placed nuclei, mild to moderate anisonucleosis, slightly coarse hyperchromatin, occasional prominent nucleoli, and orangeophilic intracytoplasmic mucin. Mitotic activity was insignificant. These findings have been reported. 5,6 Another noteworthy feature in our cases was the coexistence of clear and amorphous ball-like structures of various sizes

show abstract

Section: A Report Of Two Casesmentioning

confidence: 70%

Bronchial brushing cytology of primary signet‐ring adenocarcinoma of the lung. Another morphological feature on the papanicolaou smear: A report of two cases

Sakai

Ohbayashi

Satouchi

et al. 2010

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…Table III lists all final diagnoses. Briefly, benign lesions included inflammatory conditions (17), squamous proliferations (6), soft tissue lesions (9) and odontogenic lesions (10). Inflammatory conditions were the most common and included inflammatory pseudotumor (9), leishmaniasis (2) and fungal sinusitis (6).…”

Section: Resultsmentioning

confidence: 99%

Preoperative Washing Cytology in the Diagnosis of Maxillary Sinus Lesions

Daneshbod¹,

Khademi²,

Moemeni³

et al. 2010

Acta Cytologica

Self Cite

View full text Add to dashboard Cite

“…Cytological findings include cohesive clusters of repetitive medium-sized cells, with scant cytoplasm and uniform, small, hyperchromatic nuclei containing a finely granular, evenly distributed chromatin (Figures 2C–F). Tumor cells are often arranged around a central core of homogeneous myxoid material, or form three-dimensional, “ball-like” clusters (Table 4) (10–13, 15, 19–22, 24, 26, 33). All of these features that recapitulate the histopathology of AdCC are helpful in correctly orienting the cytological diagnosis of this neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature

et al. 2017

View full text Add to dashboard Cite

Primary pulmonary salivary gland-type tumors are rare neoplasms arising from the seromucinous submucosal glands of the lower respiratory tract (LRT), the most common of which are mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma. They are morphologically indistinguishable from their salivary gland counterpart and recognizing them is a challenge, especially on cytological specimens. We analyzed 15 cases of histologically proven primary salivary gland tumors of the LRT to identify cytomorphological features and define potential diagnostic clues that might assist cytopathologists in the preoperative diagnosis of these neoplasias. Three out of the four cases of adenoid cystic carcinomas showed the characteristic tridimensional cell clusters and hyaline globules, whereas the last one did not show malignant cells; only two cases of MEC presented the three characteristic cell types (i.e., squamous, intermediate, and mucin secreting) on cytology. Since these neoplasms are rare and do not have a completely specific set of cytological features, it is important for practicing cytopathologists to be aware of the possibility of encountering them, in specimens from patients with LRT masses, in order to render the correct diagnosis.

show abstract

Exfoliative Cytologic Findings of Primary Pulmonary Adenoid Cystic Carcinoma

Cited by 12 publications

References 9 publications

Bronchial brushing cytology of primary signet‐ring adenocarcinoma of the lung. Another morphological feature on the papanicolaou smear: A report of two cases

Bronchial brushing cytology of primary signet‐ring adenocarcinoma of the lung. Another morphological feature on the papanicolaou smear: A report of two cases

Preoperative Washing Cytology in the Diagnosis of Maxillary Sinus Lesions

Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature

Contact Info

Product

Resources

About