Exhaled 8-isoprostane in sarcoidosis: relation to superoxide anion production by bronchoalveolar lavage cells

Piotrowski, Wojciech J.; Kurmanowska, Zofia; Antczak, Adam; Marczak, Jerzy; Ciebiada, Maciej; Górski, Paweł

doi:10.1007/s00011-010-0222-4

Cited by 10 publications

(11 citation statements)

References 27 publications

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“…Elevated 8-isoprostane correlated with the percentage and number of eosinophils in BALF. In two further studies, 8-isoprostane was higher in those with stage III disease compared to stage I disease [12] and when comparing stage III disease against healthy controls [25]. No other significant difference was observed between radiological stages.…”

Section: Markers Of Oxidative Stressmentioning

confidence: 75%

“…In contrast,Piotrowski et al (2007) (16) observed no such findings with respect to the percentage of lymphocytes in BALF, however, there was a trend of increasing 8-isoprostane with increasing radiological stage although this did not reach statistical significance. Elevated 8-isoprostane correlated with the percentage and number of eosinophils in BALF.…”

mentioning

confidence: 70%

“…Biomarkers of interest related to oxidative stress were assessed across five studies (table 4). Four studies assessed 8-isoprostane in EBC; three were crosssectional case-controlled studies and one was longitudinal in design [12,17,19,25]. In all studies 8-isoprostane was significantly higher in participants with sarcoidosis.…”

Section: Markers Of Oxidative Stressmentioning

confidence: 99%

“…Of the studies which assessed inflammatory cytokines, three recruited participants receiving treatment (7) (23) (24). In the remaining study (16) all participants were treatment naïve at enrolment. No significant difference was reported in neopterin or TGF-β1 between subjects receiving treatment compared to those not receiving treatment (23).…”

Section: Cytokines and Markers Of Inflammationmentioning

confidence: 99%

“…The sampling methods also differed considerably between studies, as did the methodology for biomarker analysis (table 2). EBC was sampled using a variety of collection systems and whilst all studies described methodology of collection, only four cited reference to standardised recommendations [12,19,25,27]. A variety of chemiluminescence analysers were used to measure nitric oxide, with three studies citing sampling as per published recommendations [14,16,31].…”

Section: Overall Characteristics Of the Studiesmentioning

confidence: 99%

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The role of measuring exhaled breath biomarkers in sarcoidosis: a systematic review

et al. 2019

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Introduction: Sarcoidosis is a chronic granulomatous disease of unknown aetiology with a variable clinical course and prognosis. There is a growing need to identify non-invasive biomarkers to differentiate between clinical phenotypes, identify those at risk of disease progression and monitor response to treatment. Objectives: We undertook a systematic review and meta-analysis to evaluate the utility of breathbased biomarkers in discriminating sarcoidosis from healthy controls, alongside correlation with existing non breath-based biomarkers used in clinical practice, radiological stage, markers of disease activity and response to treatment. Methods: Electronic searches were undertaken during November 2017 using PubMed, Ebsco, Embase and Web of Science to capture relevant studies evaluating breath-based biomarkers in adult patients with sarcoidosis. Results: 353 papers were screened; 21 met the inclusion criteria and assessed 25 different biomarkers alongside VOCs in exhaled breath gas or condensate. Considerable heterogeneity existed amongst the studies in terms of participant characteristics, sampling and analytical methods. Elevated biomarkers in sarcoidosis included 8-isoprostane, carbon monoxide, neopterin, TGF-β1, TNFα, CysLT and several metallic elements including chromium, silicon and nickel. Three studies exploring VOCs were able to distinguish sarcoidosis from controls. Meta-analysis of four studies assessing alveolar nitric oxide showed no significant difference between sarcoidosis and healthy controls (2.22ppb; 95% CI-0.83, 5.27) however, a high degree of heterogeneity was observed with an I 2 of 93.4% (p<0.001). Inconsistent or statistically insignificant results were observed for correlations between several biomarkers and radiological stage, markers of disease activity or treatment.

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Section: Markers Of Oxidative Stressmentioning

confidence: 75%

mentioning

confidence: 70%

Section: Markers Of Oxidative Stressmentioning

confidence: 99%

Section: Cytokines and Markers Of Inflammationmentioning

confidence: 99%

Section: Overall Characteristics Of the Studiesmentioning

confidence: 99%

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The role of measuring exhaled breath biomarkers in sarcoidosis: a systematic review

et al. 2019

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Oxidative Stress in Sarcoidosis

Dhooria

Gupta

2014

Oxidative Stress in Applied Basic Research and Clinical Practice

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Bronchoalveolar Lavage and Other Methods to Define the Human Respiratory Tract Milieu in Health and Disease

Reynolds

2011

Lung

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During fiber-optic bronchoscopy (FOB), surface sampling of the human respiratory airways and alveolar unit can be done with bronchoalveolar lavage (BAL), plus selective sites can be brushed for cells and transbronchial biopsies made in adjacent tissue. This permits analysis of the respiratory tract's milieu in healthy normals, in those with disease, and in control subjects. These combined procedures have been an established approach for obtaining specimens for research and for clinical assessment for over four decades. However, now new less invasive sampling methods are emerging. This review emphasizes BAL and the cellular and noncellular components recovered in fluid that have contributed to improving knowledge of how the respiratory tree's innate immunity can protect, and how airway structures can become deranged and manifest disease. After a discussion of training for FOB and procedural issues, a spectrum of respiratory diseases studied with BAL is presented, including airway illness (asthma and chronic obstructive pulmonary disease), diffuse interstitial lung diseases [idiopathic pulmonary fibrosis, rheumatoid interstitial lung disease (ILD), granulomatous ILDs], lung infections, lung malignancy, and upper and lower tract airway problems. Some recent studies with exhaled breath condensate analyses are given.

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Exhaled 8-isoprostane in sarcoidosis: relation to superoxide anion production by bronchoalveolar lavage cells

Cited by 10 publications

References 27 publications

The role of measuring exhaled breath biomarkers in sarcoidosis: a systematic review

The role of measuring exhaled breath biomarkers in sarcoidosis: a systematic review

Oxidative Stress in Sarcoidosis

Bronchoalveolar Lavage and Other Methods to Define the Human Respiratory Tract Milieu in Health and Disease

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