Exhaled breath analysis in diagnosis of chronic heart failure with reduced left ventricular ejection fraction

Bykova, A. A.; Malinovskaya, L. K.; Trushina, O. V.; Чомахидзе, П. Ш.; Shaltaeva, Y R; Proshlyakov, A. Yu.; Serditenko, E. V.; Сыркин, А. Л.; Бетелин, В. Б.; Kopylov, Philippe

doi:10.17116/kardio201912061568

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…Exhaled air analysis has been performed in patients with different pathologies including chronic obstructive lung disease, cancer, asthma, lung cancer, diabetes, arthritis, heart failure, gastric cancer, chronic kidney disease, colorectal cancer, hepatocellular carcinoma, malignant pleural mesothelioma, bladder cancer, pancreatic ductal adenocarcinoma, gastro-oesophageal cancer, peritonitis-shock, head and neck squamous cell carcinoma, multiple sclerosis, and Parkinson's disease [8,9,[18][19][20][21][22][23][24][25][26][27]10,[28][29][30][31][32][33][34][35][36][37]11,[38][39][40][41][42][43][44][45][46][47][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Breathome discriminate Ischemic Heart Disease

Marzoog,

Chomakhidze,

Gognieva

et al. 2024

Preprint

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BackgroundIschemic heart disease (IHD) impacts the quality of life and has the highest mortality rate in between other cardiovascular disease in the globe.ObjectivesIHD early diagnosis, management, and prevention remain underestimated due to the poor diagnostic and therapeutic strategies including the early prevention methods.AimsTo assess the changes in the exhaled breath analysis, volatile organic compounds (VOCs), in patients with ischemic heart disease confirmed by stress computed tomography myocardial perfusion (CTP) imaging.Materials and methodsA single center observational study included 80 participants from Moscow. The participants aged ≥ 40 years and given a written consent to participate in the study. Both groups, G1=31 with vs G2=49 without post stress induced myocardial perfusion defect, passed cardiologist consultation, anthropometric measurements, blood pressure and pulse rate, echocardiography, real time breathing at rest into PTR-TOF-MS-1000, cardio-ankle vascular index, performing bicycle ergometry, and immediately after performing bicycle ergometry repeating the breathing analysis into the PTR-TOF-MS-1000, and after three minutes from the second breath, repeat the breath into the PTR-TOF-MS-1000, then performing CTP. LASSO regression with nested cross-validation was used to find association between VOCs and existence of perfusion defect. Statistical processing was carried out using the R programming language v4.2 and Python v.3.10 [^R], STATISTICA, and IBM SPSS.ResultsThe specificity 77.6 % [95 % confidence interval (CI); 0.666; 0.889], sensitivity 83.9 % [95 % CI; 0.692; 0.964], and accuracy of the diagnostic method using exhaled breath analysis, area under the curve (AUC) 83.8 % [95 % CI; 0.73655857; 0.91493173]. Whereas, the AUC of the bicycle ergometry 50.7 % [95 % CI; 0.388; 0.625], specificity 53.1 % [95 % CI; 0.392; 0.673], and sensitivity 48.4 % [95 % CI; 0.306; 0.657].ConclusionVOCs analysis appear to discriminate individuals with and without IHD with clinically acceptable diagnostic accuracy.OtherThe exhaled breath analysis reflects the myocardiocytes metabolomic signature and related intercellular homeostasis changes and regulation perturbances. Exhaled breath analysis poses a promise result to improve the diagnostic accuracy of the physical stress tests.

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Section: Introductionmentioning

confidence: 99%

Breathome discriminate Ischemic Heart Disease

Marzoog,

Chomakhidze,

Gognieva

et al. 2024

Preprint

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Breathomics Detect the Cardiovascular Disease: Delusion or Dilution of the Metabolomic Signature

Marzoog

2024

CCR

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Volatile organic compounds (VOCs) can be subdivided into exogenous and endogenous categories based on their origin. Analyzing the endogenous VOCs can provide insights into maintaining the internal organs' homeostasis. Despite the ongoing development and the current understanding, studies have suggested a link between cardiovascular metabolic alterations in patients with ischemic heart disease and elevated levels of ethane and isoprene detectable through exhaled breath analysis. Conversely, patients with chronic heart failure exhibit elevated acetone and pentane in their exhaled air. These substances originate from disturbances in the heart tissue, including cellular and subcellular modulations. Hypothetically, ethane levels in the exhaled breath analysis can demonstrate the severity of ischemic heart disease and, consequently, the risk of death in the next 10 years due to cardiovascular disease (CVD). Real-time direct mass spectrometry is the preferred method for assessing VOCs in exhaled breath analysis. The accuracy of this analysis depends on several factors, including the selection of the relevant breath fraction, the type of breath collection container (if used), and the pre-concentration technique.

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Volatilome is Inflammasome- and Lipidome-dependent in Ischemic Heart Disease

Marzoog

2024

CCR

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Ischemic heart disease (IHD) is a pathology of global interest because it is widespread and has high morbidity and mortality. IHD pathophysiology involves local and systemic changes, including lipidomic, proteomic, and inflammasome changes in serum plasma. The modulation in these metabolites is viable in the pre-IHD, during the IHD period, and after management of IHD in all forms, including lifestyle changes and pharmacological and surgical interventions. Therefore, these biochemical markers (metabolite changes; lipidome, inflammasome, proteome) can be used for early prevention, treatment strategy, assessment of the patient's response to the treatment, diagnosis, and determination of prognosis. Lipidomic changes are associated with the severity of inflammation and disorder in the lipidome component, and correlation is related to disturbance of inflammasome components. Main inflammasome biomarkers that are associated with coronary artery disease progression include IL‐1β, Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3), and caspase‐1. Meanwhile, the main lipidome biomarkers related to coronary artery disease development involve plasmalogen lipids, lysophosphatidylethanolamine (LPE), and phosphatidylethanolamine (PE). The hypothesis of this paper is that the changes in the volatile organic compounds associated with inflammasome and lipidome changes in patients with coronary artery disease are various and depend on the severity and risk factor for death from cardiovascular disease in the time span of 10 years. In this paper, we explore the potential origin and pathway in which the lipidome and or inflammasome molecules could be excreted in the exhaled air in the form of volatile organic compounds (VOCs).

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Exhaled breath analysis in diagnosis of chronic heart failure with reduced left ventricular ejection fraction

Cited by 4 publications

References 13 publications

Breathome discriminate Ischemic Heart Disease

Breathome discriminate Ischemic Heart Disease

Breathomics Detect the Cardiovascular Disease: Delusion or Dilution of the Metabolomic Signature

Volatilome is Inflammasome- and Lipidome-dependent in Ischemic Heart Disease

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