Exhaled breath biomarker sensing

Vasilescu, Alina; Hrinczenko, Borys; Swain, Greg M.; Peteu, Serban F.

doi:10.1016/j.bios.2021.113193

Cited by 71 publications

(37 citation statements)

References 103 publications

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“…N-type MOS, e.g., SnO 2 , ZnO, WO 3 , TiO 2 , MoO 3 , In 2 O 3 , and Fe 2 O 3 , as well as p-type MOS, such as Co 3 O 4 , CuO, NiO, Cr 2 O 3 , and Mn 3 O 4 , have been used in gas sensors for disease diagnosis [ 53 ]. MOS sensitivity is affected by numerous parameters, such as morphology, porosity, particle size, film thickness and doping of MOS, decoration with noble metals, as well as operation temperature [ 54 ]. Consequently, various MOS based gas-sensors of different structures (villi-like [ 55 ], nanotubes (NTs) [ 56 ], Hemi tubes [ 57 ], hierarchical fibers [ 58 ], nano-sheets [ 59 ], or NWs [ 60 ]), usually combined with noble MNPs [ 56 , 57 , 58 , 59 ], 2D-materials [ 57 ], or MOS nanoparticles [ 59 , 60 ] have been investigated as diagnostic tools for a variety of diseases.…”

Section: The Role Of Nanomaterialsmentioning

confidence: 99%

Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors

Kaloumenou

Skotadis

Lаgopati

et al. 2022

Sensors

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Early-stage disease diagnosis is of particular importance for effective patient identification as well as their treatment. Lack of patient compliance for the existing diagnostic methods, however, limits prompt diagnosis, rendering the development of non-invasive diagnostic tools mandatory. One of the most promising non-invasive diagnostic methods that has also attracted great research interest during the last years is breath analysis; the method detects gas-analytes such as exhaled volatile organic compounds (VOCs) and inorganic gases that are considered to be important biomarkers for various disease-types. The diagnostic ability of gas-pattern detection using analytical techniques and especially sensors has been widely discussed in the literature; however, the incorporation of novel nanomaterials in sensor-development has also proved to enhance sensor performance, for both selective and cross-reactive applications. The aim of the first part of this review is to provide an up-to-date overview of the main categories of sensors studied for disease diagnosis applications via the detection of exhaled gas-analytes and to highlight the role of nanomaterials. The second and most novel part of this review concentrates on the remarkable applicability of breath analysis in differential diagnosis, phenotyping, and the staging of several disease-types, which are currently amongst the most pressing challenges in the field.

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Section: The Role Of Nanomaterialsmentioning

confidence: 99%

Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors

Kaloumenou

Skotadis

Lаgopati

et al. 2022

Sensors

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“…Other diseases having been investigated to be suitable for detection by breath analysis such as cystic fibrosis [256,257] and diabetes [258]. A comprehensive review on breath biopsy describing state of the art of collecting breath samples and sensing means has recently been issued [259].…”

Section: State Of the Art In Breath Biopsymentioning

confidence: 99%

State of the Art of Chemosensors in a Biomedical Context

et al. 2022

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Healthcare is undergoing large transformations, and it is imperative to leverage new technologies to support the advent of personalized medicine and disease prevention. It is now well accepted that the levels of certain biological molecules found in blood and other bodily fluids, as well as in exhaled breath, are an indication of the onset of many human diseases and reflect the health status of the person. Blood, urine, sweat, or saliva biomarkers can therefore serve in early diagnosis of diseases such as cancer, but also in monitoring disease progression, detecting metabolic disfunctions, and predicting response to a given therapy. For most point-of-care sensors, the requirement that patients themselves can use and apply them is crucial not only regarding the diagnostic part, but also at the sample collection level. This has stimulated the development of such diagnostic approaches for the non-invasive analysis of disease-relevant analytes. Considering these timely efforts, this review article focuses on novel, sensitive, and selective sensing systems for the detection of different endogenous target biomarkers in bodily fluids as well as in exhaled breath, which are associated with human diseases.

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“…The exhaled breath contains a large number of volatile organic compounds (VOCs), sulfur-containing compounds, halogen-containing compounds, nitrogen-containing compounds, etc. [ 1 ]. Among the gases considered as biomarkers for different medical conditions, the most important are ammonia, nitric oxide, hydrogen sulfide, acetone, ethane, and aldehydes.…”

Section: Introductionmentioning

confidence: 99%

Heterostructures Based on Cobalt Phthalocyanine Films Decorated with Gold Nanoparticles for the Detection of Low Concentrations of Ammonia and Nitric Oxide

et al. 2022

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This work is aimed at the development of new heterostructures based on cobalt phthalocyanines (CoPc) and gold nanoparticles (AuNPs), and the evaluation of the prospects of their use to determine low concentrations of ammonia and nitric oxide. For this purpose, CoPc films were decorated with AuNPs by gas-phase methods (MOCVD and PVD) and drop-casting (DC), and their chemiresistive sensor response to low concentrations of NO (10–50 ppb) and NH3 (1–10 ppm) was investigated. A comparative analysis of the characteristics of heterostructures depending on the preparation methods was carried out. The composition, structure, and morphology of the resulting hybrid films were studied by X-ray photoelectron spectroscopy (XPS) and inductively coupled plasma atomic emission (ICP-AES) spectroscopy, as well as electron microscopy methods to discuss the effect of these parameters on the sensor response of hybrid films to ammonia and nitric oxide. It was shown that regardless of the fabrication method, the response of Au/CoPc heterostructures to NH3 and NO gases increased with an increase in the concentration of gold. The sensor response of Au/CoPc heterostructures to NH3 increased 2–3.3 times compared to CoPc film, whereas in the case of NO it increased up to 16 times. The detection limits of the Au/CoPc heterostructure with a gold content of ca. 2.1 µg/cm2 for NH3 and NO were 0.1 ppm and 4 ppb, respectively. It was shown that Au/CoPc heterostructures can be used for the detection of NH3 in a gas mixture simulating exhaled air (N2—74%, O2—16%, H2O—6%, CO2—4%).

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Exhaled breath biomarker sensing

Cited by 71 publications

References 103 publications

Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors

Breath Analysis: A Promising Tool for Disease Diagnosis—The Role of Sensors

State of the Art of Chemosensors in a Biomedical Context

Heterostructures Based on Cobalt Phthalocyanine Films Decorated with Gold Nanoparticles for the Detection of Low Concentrations of Ammonia and Nitric Oxide

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