Exhaled Breath Condensate pH in Lung Cancer, the Impact of Clinical Factors

Bikov, András; Lázár, Zsófia; Gyulai, Nóra; Szentkereszty, M.; Losonczy, György; Horváth, Ildikó; Gálffy, Gabriella

doi:10.1007/s00408-015-9778-7

“…The results of this study indicated that this particular neoplastic process also did not affect pH. Furthermore, no statistical differences in EBC pH were observed between patients with different stages of tumor growth [56,57]. However, two publications have provided conflicting reports on the impact of tumor histology.…”

Section: Lung Cancermentioning

confidence: 48%

“…Nevertheless, EBC pH levels are not a predictive factor for survival in lung cancer populations. It should also be noted that other diseases, such as chronic heart failure, diabetes, and chronic renal failure, do not influence EBC pH [57].…”

Section: Lung Cancermentioning

confidence: 99%

“…However, two publications have provided conflicting reports on the impact of tumor histology. In the first study, Bikov et al claimed that squamus cell carcinoma (SCC) causes lower EBC pH than adenocarcinoma (7.09 vs. 7.80; p<0.01) [57]. In contrast, the authors of the second work argue that tumor histology has no impact EBC pH [56].…”

Section: Lung Cancermentioning

confidence: 99%

“…Patients with a chronic cough due to GERD tend to have lower EBC pH levels than individuals who have a chronic cough, but no reflux (7.56 vs. 7.88, p=0.028) [66]. EBC pH can also serve as a biomarker of GERD among lung cancer patients (7.09 vs. 7.73, p=0.04) [57] but not among asthmatic patients [31,34,67]. In the case of chronic obstructive lung disease, there are conflicting data.…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

See 2 more Smart Citations

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

Muza¹,

Konieczna²,

Baczek³

2019

Pharm Anal Acta

1

0

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Exhaled breath condensate (EBC) sample analysis is an entirely non-invasive novel sample collection method that is fast, easy to perform, and effort-appeared independent. EBC samples can be very useful in identifying the biomarkers of many diseases. This review provides an updated overview of EBC pH disturbances in different disorders as well as physiological levels among healthy individuals since 2012. Our meta-analysis addresses some of the key questions related to sample processing before pH measurement and discusses various methods of condensate standardization that can be employed prior to conducting a pH assay. Given the recent widespread interest in research into the use of EBC to identify biomarkers, it is necessary to establish a pathway leading from analytical methods for biomarker evaluation using EBC pH to clinical applications of this technology. This review fills a gap in the literature and attempts to connect theory to practical analytical approaches to analyzing EBC samples and making critical treatmentrelated decisions next to the patient's bed.

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“…Furthermore, no statistical differences in EBC pH were observed between patients with different stages of tumor growth [56,57]. However, two publications have provided conflicting reports on the impact of tumor histology.…”

Section: Lung Cancermentioning

confidence: 97%

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

Muża¹,

Konieczna²,

Bączek³

2018

Preprint

0

View full text Add to dashboard Cite

Exhaled breath condensate (EBC) sample analysis is an entirely non-invasive novel sample collection method that is fast, easy to perform, and effort-appeared independent. EBC samples can be very useful in identifying the biomarkers of many diseases. This review provides an updated overview of EBC pH disturbances in different disorders as well as physiological levels among healthy individuals since 2012. Our meta-analysis addresses some of the key questions related to sample processing before pH measurement and discusses various methods of condensate standardization that can be employed prior to conducting a pH assay. Given the recent widespread interest in research into the use of EBC to identify biomarkers, it is necessary to establish a pathway leading from analytical methods for biomarker evaluation using EBC pH to clinical applications of this technology. This review fills a gap in the literature and attempts to connect theory to practical analytical approaches to analyzing EBC samples and making critical treatment-related decisions next to the patient's bed.

show abstract

Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score

Rubio,

Müller,

Mehta

et al. 2023

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Background Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the International Association for the Study of Lung Cancer (IASLC) database indicates that early diagnosis is significantly associated with favorable outcome. However, since symptoms of LC at early stages are unspecific and resemble those of benign pathologies, current diagnostic approaches are mostly initiated at advanced LC stages. Methods We developed a LC diagnosis test based on the analysis of distinct RNA isoforms expressed from the GATA6 and NKX2-1 gene loci, which are detected in exhaled breath condensates (EBCs). Levels of these transcript isoforms in EBCs were combined to calculate a diagnostic score (the LC score). In the present study, we aimed to confirm the applicability of the LC score for the diagnosis of early stage LC under clinical settings. Thus, we evaluated EBCs from patients with early stage, resectable non-small cell lung cancer (NSCLC), who were prospectively enrolled in the EMoLung study at three sites in Germany. Results LC score-based classification of EBCs confirmed its performance under clinical conditions, achieving a sensitivity of 95.7%, 91.3% and 84.6% for LC detection at stages I, II and III, respectively. Conclusions The LC score is an accurate and non-invasive option for early LC diagnosis and a valuable complement to LC screening procedures based on computed tomography.

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Exhaled Breath Condensate pH in Lung Cancer, the Impact of Clinical Factors

Abstract: Although, EBC pH is unchanged in lung cancer, lower EBC pH values are associated with distinct phenotypes. Our findings could facilitate further research on airway acidity in lung cancer.

Cited by 5 publications

References 35 publications

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

A Review of the Usefulness of Non-invasive Exhaled Breath Condensate pH Analysis for Diseases Diagnosis with Elements of Meta-analysis: An Update from 2012

Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score

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