Exhaled breath VOCs are associated with nocturnal wakening in asthmatic children

Wang, Yuanyue; Hashimoto, Simone; Brinkman, Paul; Vink, T. J.; Weda, Hans; Knobel, Hugo H.; Nijsen, Tamara M.E.; Rattray, Nicholas A.; Montuschi, Paolo; Santonico, Marco; Pennazza, Giorgio; D’Amico, A.; Fleming, Louise; Murray, Clare; Corfield, Julie; Bisgaard, Hans; Bush, Andrew; Aalderen, Wim van; Chung, Fan; Shaw, Dominic; Pandis, Ioannis; Bansal, Aruna T.; Roberts, G. Fulton; Sterk, Peter J.; Fowler, Stephen

doi:10.1183/13993003.congress-2015.pa2083

Cited by 3 publications

(4 citation statements)

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“…Breathprints were significantly different in eosinophilic compared to neutrophilic (accuracy 73%, P = 0.008, AUROC = 0.92), as well as paucigranulocytic asthma (accuracy 74%, P = 0.004, AUROC = 0.79), and neutrophilic clustered distinctly from the paucigranulocytic phenotype (accuracy 90%, P = 0.001, AUROC = 0.88), suggesting the potential of using an e-NOSE as a less-invasive alternative to sputum cytology. Similarly, Wagener et al [ 74 ], by means of a platform with four different e-NOSEs (Tor Vergata, Cyranose 320, Owlstone Lonestar, and Common Invent) separated eosinophilic from non-eosinophilic asthma breathprints in 27 patients with an accuracy of 85% and AUROC of 99%[ 74 ]. In addition, Brinkman et al [ 43 ] used the aforementioned platform with four different e-NOSEs in a population of 78 patients with severe asthma, revealing exhaled molecular phenotypes which were associated with changing inflammatory profile and oral steroid use.…”

Section: E-nose Applications In Asthmamentioning

confidence: 99%

Exhaled volatile organic compounds for diagnosis and monitoring of asthma

Savito,

Scarlata,

Bikov

et al. 2023

World J Clin Cases

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The modern medical education system has gradually evolved starting from 1910 incorporating the suggestions by Abraham Flexner, his public disclosure of the poor conditions at many medical schools provided a means to galvanize all the constituencies needed for reform to occur. He could say what other reformers could not, due to their links to the medical education community. But now we are again going back to a pre-Flexnerian state due to multiple reasons such as gradually diminishing importance of basic science subjects for the students, the decline in the number and quality of investigator initiated research among clinical researchers, lesser emphasis to bedside training by means of detailed clinical examination and making appropriate observation of signs to reach to a diagnosis rather than over reliance on the laboratory tests and radiological modalities for the diagnosis, poor exposure to basic clinical skills starting from college throughout residency and the trend of disrespect and absenteeism from both theoretical and clinical/practical classes. The attitude of students is just to complete their required attendance so that they are not barred from appearing in examinations. This de-Flexnerization trend and regression to pre-Flexnerian era standards, ideologies, structures, processes, and attitudes, are bound to beget pre-Flexnerian outcomes, for you get what you designed for.

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Section: E-nose Applications In Asthmamentioning

confidence: 99%

Exhaled volatile organic compounds for diagnosis and monitoring of asthma

Savito,

Scarlata,

Bikov

et al. 2023

World J Clin Cases

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“…This is important because the lack of an easily accessible gold-standard test to diagnose asthma frequently results in misdiagnosis [1,2]. Recent research suggests the composition of volatile organic compounds (VOCs) in exhaled breath ('breathomics') may be suitable to diagnose, monitor and phenotype asthma in the future [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The utility of a standardised breath sampler in school age children within a real-world prospective study

Bhavra¹,

Wilde²,

Richardson³

et al. 2022

J. Breath Res.

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Clinical assessment of paediatric asthmatics is problematic, and non-invasive biomarkers are needed urgently. Monitoring exhaled volatile organic compounds (VOCs) is an attractive alternative to invasive tests (blood and sputum), and may be used as frequently as required. Standardised reproducible breath-sampling is essential for exhaled-VOC analysis, and although the ReCIVA (Owlstone Medical Limited) breath-sampler was designed to satisfy this requirement, paediatric use was not in the original design brief. The efficacy of the ReCIVA for sampling paediatric-breath has been studied, and 90 breath-samples from 64 children (5-15 years) with, and without asthma (controls), were collected with two different ReCIVA units. Seventy samples (77.8%) contained the specified 1L of sampled-breath. Median sampling times were longer in children with acute asthma (770.2 s, range: 532.2-900.1 s) compared to stable asthma (690.6 s, range: 477.5-900.1 s; p=0.01). The ReCIVA successfully detected operational faults, in 21 samples. A leak, caused by a poor fit of the face mask seal was the most common (15); the others were USB communication-faults (5); and, a single instance of a file-creation error. Paediatric breath-profiles were reliably monitored, however synchronisation of sampling to breathing-phases was sometimes lost, causing some breaths not to be sampled, and some to be sampled continuously. This occurred in 60 (66.7%) of the samples and was a source of variability. Three samples were lost from a combination of factors, however, and importantly, multi-variate modelling of untargeted VOC analysis indicated the absence of significant batch effects for 8 operational variables. The ReCIVA appears suitable for paediatric breath-sampling. Post-processing of breath-sample meta-data is recommended to assess the quality of sample-acquisition. Further, future studies should explore the effect of pump-synchronisation faults on recovered VOC profiles, and mask sizes to fit all ages will reduce the potential for leaks and importantly, provide higher levels of comfort to children with asthma.

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“…Of the abstracts not subsequently published in full—Gahleitner et al do not report any results; while Brinkman et al report a cluster analysis identifying groups which differ significantly in clinical parameters. Wang et al found a correlation with night waking but not with asthma control; whereas Vijverberg et al report an area under the curve of between 0.71 and 0.97 for the identification of disease control.…”

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confidence: 99%

“…We identified 17 references to pediatric asthma breathomic studies. Six were abstracts, of which three were not published in full elsewhere [3][4][5] ; two presented identical data − early findings from a study by the review authors which is yet to be published 6,7 ; and one has since been published in full. 8 The list of full studies identified by our search is similar but not identical to that of Neerincx et al They included two papers 9,10 examining pre-school wheeze (not asthma), while we identified a paper published more than 10 years ago 11 Overall we found little to either challenge or expand the findings of their review; the future of pediatric breathomics now lies in the ability to validate these findings in prospective cohort studies.…”

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confidence: 99%