Exhaled nitric oxide before and after cardiac surgery with cardiopulmonary bypass—response to acetylcholine and nitroglycerin

Törnberg, Daniel C.; Angdin, Monika; Settergen, G.; Líška, Ján; Lundberg, Jon O.; Weitzberg, Eddie

doi:10.1093/bja/aei027

Cited by 22 publications

(18 citation statements)

References 20 publications

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“…Indeed, similar values were detected in the control group (0.17 ± 0.13) and preoperative CABG patients (0.18 ± 0.11), whereas only slightly higher levels were found in the preoperative valve patients (0.25 ± 0.16) compared with the other groups ( Figure 4). Pre (0.25 ± 0.16) and postoperative (0.20 ± 0.19) plasma NO 2 -concentrations in patients submitted to valve surgery were similar (P = 0.6875). In the group that underwent CABG, the plasma NO 2 -concentration significantly increased postoperatively (preoperative level = 0.18 ± 0.11, postoperative level = 0.47 ± 0.55; P = 0.0156) ( Figure 5).…”

Section: Resultsmentioning

confidence: 81%

“…Cardiaca Surgical Procedures. 5000 rpm for 10 minutes, at 4 o C. The plasma was deproteinated and stored at -70ºC for later NO 2 -level measurement by NO/ozone chemiluminescence.…”

Section: Methodsmentioning

confidence: 99%

“…The measurement of pulmonary vasoreactivity is important not only in ischemiareperfusion, but also in patients with pulmonary hypertension, sepsis, and acute respiratory distress syndrome [2].…”

Section: Introductionmentioning

confidence: 99%

“…In this context, investigations on how exhaled NO concentrations vary in the postoperative period of cardiac surgery will certainly contribute to new clinical findings. It is worth mentioning that exhaled NO expresses microcirculatory phenomena better than the measurement of NO 2 -levels in plasma samples collected from the pulmonary artery. Hence, assessment of exhaled NO may be more representative of vasoreactivity in the case of pulmonary hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Nitrite exhaled breath condensate study in patients undergoing cardiopulmonary bypass cardiac surgery

Augusto

Reis²,

Capellini³

et al. 2011

Rev Bras Cir Cardiovasc

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ResumoIntrodução: Estudos mostrando alterações das concentrações de nitrito (NO 2 -) exalado, com biomarcador de lesão, são raros em pacientes submetidos à cirurgia cardíaca. Nesse contexto, o seu estudo no pré e pós-operatório de cirurgias cardíacas poderá contribuir para novos dados clínicos.Objetivo: O objetivo foi comparar os níveis de nitrito (NO 2 -) do condensado do exalado pulmonar (CEP) no pré e pós-operatório de cirurgia cardíaca com circulação extracorpórea.Métodos: Vinte e oito indivíduos foram alocados em três grupos: 1) controle, 2) revascularização do miocárdio e 3) correção valvar. Os níveis de NO 2 -foram dosados por quimioluminiscência em amostras de CEP e sangue. Os dados foram analisados pelos testes Mann-Whitney e Wilcoxon.Resultados: 1) Os níveis de NO 2 -no CEP dos grupos 2 e 3 no pré-operatório foram superiores aos do grupo controle; 2) Os níveis de NO 2 -no CEP do Grupo 3 foram maiores no pré que no pós-operatório 24h; 3) Os níveis de NO 2 -plasmático do Grupo 2 foram menores no pré que no pós-operatório 24h e; 4) Não houve diferença na concentração de NO 2 -plasmático entre os grupos 2 e 3 no pré-operatório.Conclusão: Esses dados sugerem que a dosagem de NO 2 -no CEP é viável em pacientes submetidos à cirurgia cardíaca. Descritores 16AUGUSTO, VS ET AL -Estudo do nitrito do condensado do exalado pulmonar em pacientes submetidos à cirurgia cardíaca Bras Cir Cardiovasc 2011; 26.1: 15-20 Rev

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Section: Resultsmentioning

confidence: 81%

“…Cardiaca Surgical Procedures. 5000 rpm for 10 minutes, at 4 o C. The plasma was deproteinated and stored at -70ºC for later NO 2 -level measurement by NO/ozone chemiluminescence.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nitrite exhaled breath condensate study in patients undergoing cardiopulmonary bypass cardiac surgery

Augusto

Reis²,

Capellini³

et al. 2011

Rev Bras Cir Cardiovasc

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“…38,39 Along these lines, we and others have demonstrated that routine cardiopulmonary bypass alters GTN metabolism to evoke exhaled NO. 24,32,40 The major novel finding of the current study is the complete loss of GTN metabolism to produce exhaled NO in lungs subjected to prolonged ischemia and reperfusion during lung transplantation. This phenomenon may be explained by at least two major mechanisms: loss of enzyme activity and inactivation of NO.…”

Section: Discussionmentioning

confidence: 92%

Dynamics of Nitroglycerin-induced Exhaled Nitric Oxide After Lung Transplantation: Evidence of Pulmonary Microvascular Injury?

Gál

Kovesi

Royston

et al. 2007

The Journal of Heart and Lung Transplantation

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Background:In search of real-time molecular correlates to ischemia-reperfusion-induced lung injury, we explored the hypothesis that liberation of nitric oxide (NO) into exhaled breath after pulmonary microvascular bioconversion of nitroglycerin (GTN) is attenuated in clinical lung transplantation. Methods:Exhaled NO was measured under basal conditions and after intravenous administration of GTN in patients undergoing lung transplantation. Patients undergoing routine cardiac surgery served as controls. Basal and GTN-induced exhaled NO was also measured in donors before retrieval and after implantation in recipients. Results:The characteristic GTN-induced exhaled NO response observed in cardiac surgical patients before cardiopulmonary bypass and in lung transplant and multiple-organ donors was nearly totally abolished in lung transplant recipients. This response was also attenuated to a lesser degree in the routine cardiac surgery patients after cardiopulmonary bypass. Conclusions: These results suggest a graded influence of time-factored complete and partial ischemia on GTN-induced evolution of NO into exhaled breath, providing biochemical evidence for a degree of microvascular injury, which can be monitored non-invasively at the bedside.

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The Role of Nitric Oxide in Pulmonary Ischemia-Reperfusion Injury

Donndorf

Kaminski²,

Steinhoff³

2010

Principles of Pulmonary Protection in Heart Surgery

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Exhaled nitric oxide before and after cardiac surgery with cardiopulmonary bypass—response to acetylcholine and nitroglycerin

Cited by 22 publications

References 20 publications

Nitrite exhaled breath condensate study in patients undergoing cardiopulmonary bypass cardiac surgery

Nitrite exhaled breath condensate study in patients undergoing cardiopulmonary bypass cardiac surgery

Dynamics of Nitroglycerin-induced Exhaled Nitric Oxide After Lung Transplantation: Evidence of Pulmonary Microvascular Injury?

The Role of Nitric Oxide in Pulmonary Ischemia-Reperfusion Injury

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