Exhaled nitric oxide - circadian variations in healthy subjects

Antošová, Martina; Bencova, Alica; Psenkova, A; Herle, D; Rozborilova, Eva

doi:10.1186/2047-783x-14-s4-6

Cited by 19 publications

(12 citation statements)

References 14 publications

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“…The average FE NO values of both groups were in the normal range, but in the exposed group, they did not decline as expected during the day. [39] This increased intergroup difference was significant after the shift, indicating an increased risk of respiratory inflammation in the swimming pool environment. Similar findings were reported for public swimming pool employees.…”

Section: Lung Function Fe No and Pefmentioning

confidence: 95%

Occupational exposure to trichloramine and trihalomethanes: adverse health effects among personnel in habilitation and rehabilitation swimming pools

Westerlund

Bryngelsson

Löfstedt

et al. 2019

Journal of Occupational and Environmental Hygiene

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Personnel in swimming pool facilities typically experience ocular, nasal, and respiratory symptoms due to water chlorination and consequent exposure to disinfection by-products in the air. The aim of the study was to investigate exposure to trichloramine and trihalomethanes (chloroform, bromodichloromethane, dibromochloromethane, and bromoform) from the perspective of adverse health effects on the personnel at Swedish habilitation and rehabilitation swimming pools. The study included 10 habilitation and rehabilitation swimming pool facilities in nine Swedish cities. The study population comprised 24 exposed swimming pool workers and 50 unexposed office workers. Personal and stationary measurements of trichloramine and trihalomethanes in air were performed at all the facilities. Questionnaires were distributed to exposed workers and referents. Spirometry, fraction of exhaled nitric oxide (FE NO ), and peak expiratory flow (PEF) were measured. Personal and stationary measurements yielded trichloramine levels of 1-76 mg/m 3 (average: 19 mg/m 3 ) and 1-140 mg/m 3 (average: 23 mg/m 3 ), respectively. A slightly higher, but not significant, prevalence of reported eye-and throat-related symptoms occurred among the exposed workers than among the referents. A significantly increased risk of at least one ocular symptom was attributed to trichloramine exposure above the median (20 mg/m 3 ). Lung function (FVC and FEV1) was in the normal range according to the Swedish reference materials, and no significant change in lung function before and after shift could be established between the groups. Average FE NO values were in the normal range in both groups, but the difference in the values between the exposed workers and referents showed a significant increase after shift. Hourly registered PEF values during the day of the investigation did not show any unusual individual variability. In conclusion, the increased risk of developing at least one ocular symptom at personal trichloramine concentrations over 20 mg/m 3 combined with an increase in the difference in FE NO during the work shift of the exposed workers should not be neglected as an increased risk of respiratory inflammation in the habilitation and rehabilitation swimming pool environment.

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Section: Lung Function Fe No and Pefmentioning

confidence: 95%

Occupational exposure to trichloramine and trihalomethanes: adverse health effects among personnel in habilitation and rehabilitation swimming pools

Westerlund

Bryngelsson

Löfstedt

et al. 2019

Journal of Occupational and Environmental Hygiene

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“…As with other factors we examined, findings from other studies on FeNO levels and diurnal variability are equivocal. In a study of circadian rhythms by Antosova and colleagues [36], FeNO levels peaked in the AM, and Pijnenburg et al [50] found geometric mean levels 14% higher in the morning as compared to afternoon levels. In two different studies of asthmatic youth [37,51] there was no diurnal or day-to-day variation, and a study of children in Taiwan [29] showed FeNO measurements were lower in the mornings compared to afternoon values.…”

Section: Discussionmentioning

confidence: 97%

Reference values and factors associated with exhaled nitric oxide: U.S. youth and adults

Brody

Zhang

Kit

et al. 2013

Respiratory Medicine

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“…According to Ziętkowski et al ., monitoring the concentration of NO is a useful tool during observations of the inflammation of the lower airways in patients diagnosed with seasonal allergic rhinitis [ 18 ]. Frerie, too, confirmed that the concentration of NO in the exhaled air is a marker among inflammatory respiratory diseases [ 21 ]. In the case of patients diagnosed with allergic asthma, an increase in the concentration of NO in the exhaled air was observed [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic significance of nitric oxide concentrations in exhaled air from the airways in allergic rhinitis patients

Kłak

Krzych‐Fałta

Samoliński

et al. 2016

pdia

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IntroductionThe effect of nitric oxide (NO) on the human body is very important due its physiological regulation of the following functions of airways: modulation of ciliary movement and maintenance of sterility in sinuses.AimTo evaluate the diagnostic significance of NO concentrations in exhaled air from the upper and lower airways in patients diagnosed with allergic rhinitis (AR).Material and methodsThe subjects included in the study were a group of 30 people diagnosed with sensitivity to environmental allergens and a control group consisting of 30 healthy subjects. The measurement of NO in the air exhaled from the lower and upper airways was performed using an on-line method by means of Restricted Exhaled Breath (REB), as well as using the measurement procedure (chemiluminescence) set out in the guidelines prepared in 2005 by the American Thoracic Society and the European Respiratory Society.ResultsIn the late phase of the allergic reaction, higher values of the level of exhaled NO concentration from the lower airways were observed in the groups of subjects up to the threshold values of 25.17 ppb in the group of subjects with year-round allergic rhinitis and 21.78 ppb in the group with diagnosed seasonal allergic rhinitis. The difference in the concentration of NO exhaled from the lungs between the test group and the control group in the 4th h of the test was statistically significant (p = 0.045).ConclusionsExhaled NO should be considered as a marker of airway inflammation. It plays an important role in the differential diagnosis of allergy.

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Exhaled nitric oxide - circadian variations in healthy subjects

Cited by 19 publications

References 14 publications

Occupational exposure to trichloramine and trihalomethanes: adverse health effects among personnel in habilitation and rehabilitation swimming pools

Occupational exposure to trichloramine and trihalomethanes: adverse health effects among personnel in habilitation and rehabilitation swimming pools

Reference values and factors associated with exhaled nitric oxide: U.S. youth and adults

Diagnostic significance of nitric oxide concentrations in exhaled air from the airways in allergic rhinitis patients

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