Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD

Abstract

eNO is a good marker to identify COPD patients with eosinophilic airway inflammation.

Exhaled nitric oxide: Not associated with asthma, symptoms, or spirometry in children with sickle cell anemia

“…In our study, while FeNO was associated with IgE, having 2 or more positive skin tests, and peripheral blood eosinophilia, it was not associated with doctor diagnosis of asthma, wheeze symptoms, airway obstruction, or response to bronchodilator. While FeNO has been shown to be correlated with eosinophilic airway inflammation in the general population and among children with asthma, 30-32 it has also been shown to correlate with lymphocytic airway inflammation in lung transplant patients, 33 with both neutrophilic 34 and eosinophilic 35 airway inflammation in COPD, and with lymphocytic airway inflammation in early bronchopulmonary involvement in Crohn's disease 36 and in murine models of systemic sclerosis. 37 Future studies in SCD should include direct examination of inflammatory cell types in the sputum.…”

Nasal ventilation is an important factor in evaluating the diagnostic value of nasal nitric oxide in allergic rhinitis

“…Eosinophil cationic protein (ECP) is released by activated eosinophils and is often considered to be the marker of eosinophilic inflammation of AR . As NO activity is augmented by the nitrate‐nitrite‐NO pathway during allergic activation, and oral NO and ECP are both markers in the diagnosis of asthma, we hypothesized that there would be an association between nasal NO and ECP levels in nasal secretion in AR patients, and ECP in nasal secretion may represent the severity of nasal eosinophilic inflammation.…”

Diagnosis of asthma–COPD overlap: the five commandments

“…The increase in blood eosinophils in COPD has been associated with increased reversibility of airflow obstruction [15][16][17], with higher FeNO [18,19], and a better response to ICS in terms of improvements in lung function [15,20], prevention of exacerbations [21] and reducing the rate of decline in lung function [22]. Despite the growing evidence for the value of blood eosinophil counts as a marker of ICS response in COPD, there are no prospective ad hoc studies designed with this specific aim and there is no general agreement yet on a threshold to define high blood eosinophil counts.…”