2022
DOI: 10.3390/ijms232213928
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Exhausted but Not Senescent T Lymphocytes Predominate in Lupus Nephritis Patients

Abstract: Lupus nephritis (LN), a chronic inflammatory disease, is characterized by the substantial disruption of immune homeostasis. This study examines its effects on the T lymphocyte phenotype and, particularly, its senescence- and exhaustion-related immune alterations. T cell subpopulations were determined with flow cytometry in 30 LN patients and 20 healthy controls (HCs), according to the expression of senescence- (CD45RA, CCR7, CD31, CD28, CD57), and exhaustion- (PD1) related markers. The immune phenotype was ass… Show more

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Cited by 9 publications
(5 citation statements)
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“…Type I and II IFN possess pleiotropic downstream effects on T and B cell activation, such as promotion of T cell differentiation (effector and central memory), B cell differentiation into DN2, Bnd2, and ASC, and depending on chronicity of disease process, T and B cell exhaustion ( 62 – 66 ). These IFN downstream immunological consequences were all identified in our studies, including increased frequency of i) extrafollicular (EF) B cell subsets DN2, Bnd2, and PB cells; ii) cTph and cTfh, and iii) CD8 + TCM, and expression of CD38, PD-1 and LAG-3 in CD8 + T cells ( 67 , 68 ) ( Figures 2 , 3 ). While these findings have been previously addressed in other studies, they have all focused on adult patient cohorts, or incompletely studied – i.e., the studies focused on EF B cell subsets only, or T cell activation only, etc.…”
Section: Discussionsupporting
confidence: 60%
“…Type I and II IFN possess pleiotropic downstream effects on T and B cell activation, such as promotion of T cell differentiation (effector and central memory), B cell differentiation into DN2, Bnd2, and ASC, and depending on chronicity of disease process, T and B cell exhaustion ( 62 – 66 ). These IFN downstream immunological consequences were all identified in our studies, including increased frequency of i) extrafollicular (EF) B cell subsets DN2, Bnd2, and PB cells; ii) cTph and cTfh, and iii) CD8 + TCM, and expression of CD38, PD-1 and LAG-3 in CD8 + T cells ( 67 , 68 ) ( Figures 2 , 3 ). While these findings have been previously addressed in other studies, they have all focused on adult patient cohorts, or incompletely studied – i.e., the studies focused on EF B cell subsets only, or T cell activation only, etc.…”
Section: Discussionsupporting
confidence: 60%
“…Analyzing cell profiles, we observed a depletion of T cells in non-responder patients and a worse response ratio was consistently observed for patients poor in various T cell subpopulations. In a previous study, T lymphocyte exhaustion was associated with LN 25 , but differences comparing response and non-response to drugs have never been reported before. Perhaps insufficient or abnormal T cell function could be influencing the lack of response 26 .…”
Section: Discussionmentioning
confidence: 80%
“…In elderly patients, DN B cells seemed to behave more as senescent or exhausted cells than naïve B cells [ 30 , 31 ]. Senescent phenomena were not found to predominate in SLE [ 11 , 12 ], although they are prominent findings in chronic inflammatory diseases [ 32 , 33 ].…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies have shown that DN2 B cells were mainly increased in active SLE and in the presence of lupus nephritis, and they were positively correlated with anti-RNA, anti-Sm, and anti-RNP autoantibodies [ 9 , 10 , 11 ]. We have previously described the predominance of DN B cells in SLE patients, even compared to patients on hemodialysis, selected as a representative group of patients with senescent adaptive immunity [ 11 , 12 , 13 ].…”
Section: Introductionmentioning
confidence: 99%