Exhaustion and senescence of CD4 and CD8 T cells that express co-stimulatory molecules CD27 and CD28 in subjects that acquired HIV by drug use or by sexual route

Bănică, Leontina; Vlaicu, Ovidiu; Jipa, Raluca; Abagiu, Adrian; Nicolae, Ionelia; Neaga, Emil; Oțelea, Dan; Paraschiv, Simona

doi:10.18683/germs.2021.1242

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…Since chronic HIV infection is associated with premature cellular senescence (17), we examined the frequencies of 4 for regression details).…”

Section: Cd38 Expressing Terminally Differentiated Senescent-like T C...mentioning

confidence: 99%

Opioids exacerbate inflammation in people with well-controlled HIV

Dang,

Nelson,

Feaster

et al. 2023

Front. Immunol.

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IntroductionPeople with HIV (PWH) are known to have underlying inflammation and immune activation despite virologic control. Substance use including opioid dependence is common in this population and is associated with increased morbidity and reduced lifespan. The primary objective of the present study termed opioid immunity study (OPIS), was to investigate the impact of chronic opioids in PWH.MethodsThe study recruited people with and without HIV who had opioid use disorder (OUD). Study participants (n=221) were categorized into four groups: HIV+OP+, n=34; HIV-OP+, n=66; HIV+OP-, n=55 and HIV-OP-, n=62 as controls. PWH were virally suppressed on ART and those with OUD were followed in a syringe exchange program with confirmation of OP use by urine drug screening. A composite cytokine score was developed for 20 plasma cytokines that are linked to inflammation. Cellular markers of immune activation (IA), exhaustion, and senescence were determined in CD4 and CD8 T cells. Regression models were constructed to examine the relationships of HIV status and opioid use, controlling for other confounding factors.ResultsHIV+OP+ participants exhibited highest inflammatory cytokines and cellular IA, followed by HIV-OP+ for inflammation and HIV+OP- for IA. Inflammation was found to be driven more by opioid use than HIV positivity while IA was driven more by HIV than opioid use. In people with OUD, expression of CD38 on CD28-CD57+ senescent-like T cells was elevated and correlated positively with inflammation.DiscussionGiven the association of inflammation with a multitude of adverse health outcomes, our findings merit further investigations to understand the mechanistic pathways involved.

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“…Since chronic HIV infection is associated with premature cellular senescence (17), we examined the frequencies of 4 for regression details).…”

Section: Cd38 Expressing Terminally Differentiated Senescent-like T C...mentioning

confidence: 99%

Opioids exacerbate inflammation in people with well-controlled HIV

Dang,

Nelson,

Feaster

et al. 2023

Front. Immunol.

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Changes of T lymphocyte subpopulations and their roles in predicting the risk of Parkinson’s disease

Peng

et al. 2022

J Neurol

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T lymphocytes are involved in the pathogenesis of Parkinson’s disease (PD), while the heterogeneity of T-cell subpopulations remains elusive. In this study, we analyzed up to 22 subpopulations of T lymphocytes in 115 PD patients and 60 matched healthy controls (HC) using flow cytometry. We found that PD patients exhibited decreased naïve CD8+ T cells (CD3+ CD8+ CD45RA+ CD45RO−) and increased late-differentiated CD4+ T cells (CD3+ CD4+ CD28− CD27−), compared to HC, which were not affected by anti-parkinsonism medication administration. The proportion of naïve CD8+ T cells in PD patients was positively correlated with their severity of autonomic dysfunction and psychiatric complications, but negatively associated with the severity of rapid eye movement and sleep behavior disorder. The proportion of late-differentiated CD4+ T cells was negatively correlated with the onset age of the disease. We further developed individualized PD risk prediction models with high reliability and accuracy on the base of the T lymphocyte subpopulations. These data suggest that peripheral cellular immunity is disturbed in PD patients, and changes in CD8+ T cells and late-differentiated CD4+ T cells are representative and significant. Therefore, we recommend naïve CD8 + and late-differentiated CD4+ T cells as candidates for multicentric clinical study and pathomechanism study of PD.

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Immunosenescence and its related comorbidities in older people living with HIV

He,

Wang,

et al. 2024

Infectious Diseases &Amp; Immunity

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With the aging of the global population, older people living with HIV (OPLWH) have emerged as a focal point in HIV/AIDS research. Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overall poor immune reconstitution and elevated rates of age-related comorbidities, such as cardiovascular disease, bone disease, and cognitive impairment. This review aims to elucidate the mechanisms underlying immunosenescence and the interaction of immunosenescence with HIV infection, further exploring its role in the pathogenesis of HIV infection during aging. Aging-induced involution of the immune system, along with chronic inflammation and infection, can induce immunosenescence, leading to immune dysfunction that impairs the effective control of HIV infection. In addition, HIV infection induces immunosenescence through persistent inflammation and immune activation, even under treatment. The combined effects of aging and HIV infection accelerate the progression of immunosenescence in OPLWH, increasing their susceptibility to multiple age-related diseases. The unfavorable prognosis observed among OPLWH is largely attributed to increased levels of immunosenescence. A comprehensive understanding of the relationship between immunosenescence and HIV infection is crucial for developing targeted therapeutic strategies for this vulnerable population.

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Exhaustion and senescence of CD4 and CD8 T cells that express co-stimulatory molecules CD27 and CD28 in subjects that acquired HIV by drug use or by sexual route

Cited by 4 publications

References 25 publications

Opioids exacerbate inflammation in people with well-controlled HIV

Opioids exacerbate inflammation in people with well-controlled HIV

Changes of T lymphocyte subpopulations and their roles in predicting the risk of Parkinson’s disease

Immunosenescence and its related comorbidities in older people living with HIV

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