Exhaustivité des signalements de cas graves de grippe A(H1N1)2009 en Provence-Alpes-Côte d’Azur et Corse, France, 2009–2010

Farouki, K. El; Mantey, K.; Lasalle, Jean-Luc; Fuhrman, C.; Chiron, Éliane; Malfait, P

doi:10.1016/j.respe.2010.06.058

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“…However, comparisons over seasons should be made cautiously as the level of reporting may have varied over time. Completeness of the surveillance system was estimated in two regions by capture-recapture analysis: it was 90% during the pandemic in the Provence-Cote d'Azur region [10] and 80% in 2012/13 in the Pays-dela-Loire region [11]. There may be a tendency towards decreasing completeness over time but as surveillance remained active throughout the entire study period, with ICU wards being contacted regularly by their InVS regional office (Cire), we believe that this decline has remained limited.…”

Section: Discussionmentioning

confidence: 99%

Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons

et al. 2015

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During the 2009/10 pandemic, a national surveillance system for severe influenza cases was set up in France. We present results from the system's first four years. All severe influenza cases admitted to intensive care units (ICU) were reported to the Institut de Veille Sanitaire using a standardised form: data on demographics, immunisation and virological status, risk factors, severity (e.g. acute respiratory distress syndrome (ARDS) onset, mechanical ventilation, extracorporeal life support) and outcome. Multivariate analysis was performed to identify factors associated with ARDS and death. The number of confirmed influenza cases varied from 1,210 in 2009/10 to 321 in 2011/12. Most ICU patients were infected with A(H1N1)pdm09, except during the 2011/12 winter season when A(H3N2)-related infections predominated. Patients' characteristics varied according to the predominant strain. Based on multivariate analysis, risk factors associated with death were age ≥ 65 years, patients with any of the usual recommended indications for vaccination and clinical severity. ARDS occurred more frequently in patients who were middle-aged (36-55 years), pregnant, obese, or infected with A(H1N1)pdm09. Female sex and influenza vaccination were protective. These data confirm the persistent virulence of A(H1N1)pdm09 after the pandemic and the heterogeneity of influenza seasons, and reinforce the need for surveillance of severe influenza cases.

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Section: Discussionmentioning

confidence: 99%