In this article we are interested in the following non-linear Schrödinger equation with non-local regional diffusionwhere ǫ > 0, 0 < α < 1, (−∆) α ρǫ is a variational version of the regional laplacian, whose range of scope is a ball with radius ρ ǫ (x) = ρ(ǫx) > 0, where ρ is a continuous function. We give general conditions on ρ and f which assure the existence and multiplicity of solution for (P ǫ ). MSC: 45G05, 35J60, 35B25