This article investigates the solvability problem of fourth-order differential equations with two-point boundary conditions; specifically, conclusions regarding sign-changing solutions are obtained. The methods used in this article are fixed-point theorems on lattices. Firstly, under some sublinear conditions, the existence of three nontrivial solutions is demonstrated, including a sign-changing solution, a negative solution and a positive solution. Secondly, under some unilaterally asymptotically linear and superlinear conditions, the existence of at least one sign-changing solution is proved. Finally, this article provides several specific examples to illustrate the obtained conclusions.