Given a smooth, symmetric, homogeneous of degree one function f = f (λ 1 , · · · , λn) satisfying ∂ i f > 0 for all i = 1, · · · , n, and an oriented, properly embedded smooth cone C n in R n+1 , we show that under some suitable conditions on f and the covariant derivatives of the second fundamental form of C, there is at most one f self-shrinker (i.e. an oriented hypersurface Σ n in R n+1 for which f (κ 1 , · · · , κn) + 1 2 X · N = 0 holds, where X is the position vector, N is the unit normal vector, and κ 1 , · · · , κn are principal curvatures of Σ) that is asymptotic to the given cone C at infinity.