Existence of Staphylococcus aureus correlates with the progression of extramammary Paget's disease: potential involvement of interleukin-17 and M2-like macrophage polarization

Sakamoto, Ryoko; Kajihara, Ikko; Mijiddorj, Tselmeg; Maeda‐Otsuka, Saki; Sawamura, Soichiro; Nishimura, Yuki; Kanemaru, Hisashi; Yamada‐Kanazawa, Saori; Nakamura, Kayo; Honda, Noritoshi; Makino, Katsunari; Aoi, Jun; Igata, Toshikatsu; Makino, Takamitsu; Masuguchi, Shinichi; Fukushima, Satoshi; Morinaga, Jun; Komohara, Yoshihiro; Ihn, Hironobu

doi:10.1684/ejd.2021.3972

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…24 Some research observed that S. aureus can fuel disease progression in cutaneous tumors by activating the proliferation of tumor cells, enhancing expression of oncogenic microRNA, and inducing immunosuppression. [25][26][27][28][29] These studies provide clues for insights into how S. aureus affects the prognosis of IPMN-ICs. The presence of M. koreensis was also relevant to the poor overall survival of IPMN-IC.…”

Section: Hazaka Et Al Analyzed the Tumoralmentioning

confidence: 98%

The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

Zou,

Mo,

Jia

et al. 2023

J of Gastro and Hepatol

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Background and AimPancreatic intraductal papillary mucinous neoplasm (IPMN) is one of the most common precancerous lesions of pancreatic carcinoma. Studies have found that the tumoral microbiome has an important influence on pancreatic carcinoma. However, the tumoral microbiome of IPMNs has rarely been explored.MethodsTumoral microbiome gene sequencing was carried out using 16 specimens of IPMN and 45 specimens of IPMN with associated invasive carcinoma (IPMN‐IC) by 2bRAD sequencing for microbiome. The profile of the tumoral microbiome was summarized. Associations of the tumoral microbiome with disease grade, histological subtype, and prognosis were analyzed.ResultsA total of 598 species of microbes were identified, comprising 228 genera, 109 families, 60 orders, 29 classes, 14 phyla, and 2 kingdoms. The genus Pseudomonas was detected more frequently and had higher relative abundance in IPMN‐ICs; Alcaligenes faecalis was detected with higher relative abundance in IPMNs. Bifidobacterium pseudolongum had a higher relative abundance in the IPMN‐IC group, regardless of histological subtype. Moreover, among patients with IPMN‐ICs, those with a high relative abundance of B. pseudolongum had better overall survival than those with a low relative abundance. Patients who were positive for Staphylococcus aureus or Mycolicibacillus koreensis had shorter survival. The presence of S. aureus was an independent risk factor for poor prognosis.ConclusionsThere are enriching tumoral microbes in IPMN. The tumoral microbiome of IPMN is different from that of IPMN‐IC.

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Section: Hazaka Et Al Analyzed the Tumoralmentioning

confidence: 98%

The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

Zou,

Mo,

Jia

et al. 2023

J of Gastro and Hepatol

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“…Clostridium butyricum -derived extracellular vesicles affect repolarization of M2 macrophages and protect against colitis ( 50 ). In extramammary Paget’s disease high levels of Staphylococcus aureus were detected that coincided with CD163-positive M2-like macrophages ( 51 ), whereas potential association of Shewanella , V. parahaemolyticus , and Microbacterium sp. with prostate cancer has been described, with indications that malignant tissue has higher proportion of M2 microphages ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma

Pentimalli¹,

Krstic‐Demonacos²,

Costa³

et al. 2023

Front. Immunol.

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IntroductionDespite increased attention on immunotherapy, primarily immune checkpoint blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability remain questioned. One potential explanation for different responses to immunotherapy is the gut and intratumor microbiota; however, these remain an underexplored facet of MMe. This article highlights the cancer intratumor microbiota as a novel potential prognostic indicator in MMe.MethodsTCGA data on 86 MMe patients from cBioPortal underwent bespoke analysis. Median overall survival was used to divide patients into “Low Survivors” and “High Survivors”. Comparison of these groups generated Kaplan-Meier survival analysis, differentially expressed genes (DEGs), and identification of differentially abundant microbiome signatures. Decontamination analysis refined the list of signatures, which were validated as an independent prognostic indicator through multiple linear regression modelling and Cox proportional hazards modelling. Finally, functional annotation analysis on the list of DEGs was performed to link the data together.Results107 genera signatures were significantly associated with patient survival (positively or negatively), whilst clinical characteristic comparison between the two groups demonstrated that epithelioid histology was more common in “High Survivors” versus biphasic in “Low Survivors”. Of the 107 genera, 27 had published articles related to cancer, whilst only one (Klebsiella) had MMe-related published articles. Functional annotation analysis of the DEGs between the two groups highlighted fatty acid metabolism as the most enriched term in “High Survivors”, whilst for “Low Survivors” the enriched terms primarily related to cell cycle/division. Linking these ideas and findings together is that the microbiome influences, and is influenced by, lipid metabolism. Finally, to validate the independent prognostic value of the microbiome, multiple linear regression modelling as well as Cox proportional hazards modelling were employed, with both approaches demonstrating that the microbiome was a better prognostic indicator than patient age or stage of the cancer.DiscussionThe findings presented herein, alongside the very limited literature from scoping searches to validate the genera, highlight the microbiome and microbiota as a potentially rich source of fundamental analysis and prognostic value. Further in vitro studies are needed to elucidate the molecular mechanisms and functional links that may lead to altered survival.

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“…12 Furthermore, the relationship between inflammatory molecules and tumor growth has been suggested in patients with EMPD as well. 13,14 However, no inflammatory biomarkers, which reflect tumor activity of EMPD and can be feasibly analyzed routinely, have been reported. The NLR is an inflammatory biomarker that can reflect disease activity in various cancer types, including skin cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has been known that cancers establish “tumor microenvironment” to enhance their growth 12 . Furthermore, the relationship between inflammatory molecules and tumor growth has been suggested in patients with EMPD as well 13,14 . However, no inflammatory biomarkers, which reflect tumor activity of EMPD and can be feasibly analyzed routinely, have been reported.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio is a potential prognostic biomarker for extramammary Paget disease: A retrospective study

Maeda

Uehara

Toyoshima

et al. 2022

The Journal of Dermatology

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Extramammary Paget disease (EMPD) is a rare, cutaneous malignancy that may occur in the genital and perianal regions in persons aged >60 years. 1 The incidence rate of EMPD in the United States has increased from approximately 0.3 per 10 million population in 1973 to more than 10 times that rate in 2013. 2 Prognosis of EMPD without distant metastasis is favorable, with a 5-year survival rate of 84%. However, once distant metastases occur, this rate falls to 7%. 3 Several studies have shown that cytotoxic anticancer agents, such as docetaxel, showed some efficacy in advanced EMPD cases.However, curative treatment has not been established, particularly in patients with visceral metastasis. [4][5][6] The neutrophil-to-lymphocyte ratio (NLR) utilizes a ratio of neutrophils to lymphocytes counted in peripheral blood to reflect prognosis and disease activity in many cancer types, including skin cancer. [7][8][9][10] In EMPD, similar to other skin cancers, sentinel lymph node biopsy positivity has been reported to be higher in cases of high NLR values. 8 However, the usefulness of NLR in predicting disease progression or survival in patients with EMPD has not been assessed. We hypothesized that NLR could help predicting prognosis in patients with EMPD and other cancer types. Therefore, we

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Existence of Staphylococcus aureus correlates with the progression of extramammary Paget's disease: potential involvement of interleukin-17 and M2-like macrophage polarization

Cited by 5 publications

References 27 publications

The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

The tumoral microbiome of pancreatic intraductal papillary mucinous neoplasm: A single‐center retrospective cohort study

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma

Neutrophil‐to‐lymphocyte ratio is a potential prognostic biomarker for extramammary Paget disease: A retrospective study

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