Exiting the Anthropocene: Achieving personal and planetary health in the 21st century

Prescott, Susan L.; Logan, Alan C.; Bristow, Jamie; Rozzi, Ricardo; Moodie, Rob; Redvers, Nicole; Haahtela, Tari; Warber, Sara; Hancock, Trevor; Berman, Brian M.

doi:10.1111/all.15419

Cited by 39 publications

(36 citation statements)

References 131 publications

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“…There is a growing call for an integrated approach to health on all scales. This recognizes and addresses the interconnected factors that promote resilience and decrease vulnerability from the first moments of life—including the attitudes and value systems that govern these—for mutual benefits to individuals, communities, and natural systems upon which we depend [ 97 , 133 ].…”

Section: Towards Greater Integration: From Biopsychosocial Research T...mentioning

confidence: 99%

Vitality Revisited: The Evolving Concept of Flourishing and Its Relevance to Personal and Public Health

Logan¹,

Berman

Prescott

2023

IJERPH

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Human flourishing, the state of optimal functioning and well-being across all aspects of an individual’s life, has been a topic of philosophical and theological discussion for centuries. In the mid-20th century, social psychologists and health scientists began exploring the concept of flourishing in the context of health and high-level wellness. However, it is only in recent years, in part due to the USD 43 million Global Flourishing Study including 22 countries that flourishing has entered the mainstream discourse. Here, we explore this history and the rapid acceleration of research into human flourishing, defined as “the relative attainment of a state in which all aspects of a person’s life are good” by the Harvard University’s Flourishing Program. We also explore the construct of “vitality”, which refers to a sense of aliveness, energy, and motivation; we contend that this has been neglected in the flourishing movement. We explore why incorporating measures of vitality together with a broader biopsychosocial approach considers all dimensions of the environment across time (the total exposome), which will greatly advance research, policies, and actions to achieve human flourishing.

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Section: Towards Greater Integration: From Biopsychosocial Research T...mentioning

confidence: 99%

Vitality Revisited: The Evolving Concept of Flourishing and Its Relevance to Personal and Public Health

Logan¹,

Berman

Prescott

2023

IJERPH

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“…The COVID-19 pandemic showed the priorities of the societies: health and safety come first. For a more sustainable future, integrated prevention of human disease, climate crisis, and nature loss with the new technical and scientific innovations makes sense ( 112 , 113 ). Management of the environmentally-driven allergic and respiratory disease may demonstrate the transition and pave the way guided by the Helsinki Alert 2015 ( 114 ) and Declaration 2020 ( 115 ).…”

Section: Conclusion – From Great Acceleration To Great Slowdownmentioning

confidence: 99%

A short history from Karelia study to biodiversity and public health interventions

Haahtela

Alenius

Auvinen³

et al. 2023

Front. Allergy

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Contact with natural environments enriches the human microbiome, promotes immune balance and protects against allergies and inflammatory disorders. In Finland, the allergy & asthma epidemic became slowly visible in mid 1960s. After the World War II, Karelia was split into Finnish and Soviet Union (now Russia) territories. This led to more marked environmental and lifestyle changes in the Finnish compared with Russian Karelia. The Karelia Allergy Study 2002–2022 showed that allergic conditions were much more common on the Finnish side. The Russians had richer gene-microbe network and interaction than the Finns, which associated with better balanced immune regulatory circuits and lower allergy prevalence. In the Finnish adolescents, a biodiverse natural environment around the homes associated with lower occurrence of allergies. Overall, the plausible explanation of the allergy disparity was the prominent change in environment and lifestyle in the Finnish Karelia from 1940s to 1980s. The nationwide Finnish Allergy Programme 2008–2018 implemented the biodiversity hypothesis into practice by endorsing immune tolerance, nature contacts, and allergy health with favorable results. A regional health and environment programme, Nature Step to Health 2022–2032, has been initiated in the City of Lahti, EU Green Capital 2021. The programme integrates prevention of chronic diseases (asthma, diabetes, obesity, depression), nature loss, and climate crisis in the spirit of Planetary Health. Allergic diseases exemplify inappropriate immunological responses to natural environment. Successful management of the epidemics of allergy and other non-communicable diseases may pave the way to improve human and environmental health.

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“…Currently, the problem of food allergenicity is extremely relevant because the documented rapid growth of population allergization is becoming one of the key challenges for mo dern medicine (Prescott et al, 2022). In this regard, modern plant breeders are working in two directions: (1) creation of new hypoallergenic forms of agricultural food plants and (2) identification of new plant food allergens and of molecular mechanisms of their action (Hong et al, 2021;Cavazza et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Russian Science Foundation grant No. 20-14-00140 supported this study. The authors are thankful to the multi-access Center “Bioinformatics” for the use of computational resources as supported by Russian government project FWNR-2022-0020 and the Russian Federal Science and Technology Program for the Development of Genetic Technologies.

et al. 2023

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It is generally accepted that during the domestication of food plants, selection was focused on their productivity, the ease of their technological processing into food, and resistance to pathogens and environmental stressors. Besides, the palatability of plant foods and their health benefits could also be subjected to selection by humans in the past. Nonetheless, it is unclear whether in antiquity, aside from positive selection for beneficial properties of plants, humans simultaneously selected against such detrimental properties as allergenicity. This topic is becoming increasingly relevant as the allergization of the population grows, being a major challenge for modern medicine. That is why intensive research by breeders is already underway for creating hypoallergenic forms of food plants. Accordingly, in this paper, albumin, globulin, and βamylase of common wheat Triticum aestivum L. (1753) are analyzed, which have been identified earlier as targets for attacks by human class E immunoglobulins. At the genomic level, we wanted to find signs of past negative selection against the allergenicity of these three proteins (albumin, globulin, and βamylase) during the domestication of ancestral forms of modern food plants. We focused the search on the TATAbinding protein (TBP)binding site because it is located within a narrow region (between positions –70 and –20 relative to the corresponding transcription start sites), is the most conserved, necessary for primary transcription initiation, and is the beststudied regulatory genomic signal in eukaryotes. Our previous studies presented our publicly available Web service Plant_SNP_TATA_Ztester, which makes it possible to estimate the equilibrium dissociation constant (KD) of TBP complexes with plant proximal promoters (as output data) using 90 bp of their DNA sequences (as input data). In this work, by means of this bioinformatics tool, 363 gene promoter DNA sequences representing 43 plant species were analyzed. It was found that compared with nonfood plants, food plants are characterized by significantly weaker affinity of TBP for proximal promoters of their genes homologous to the genes of commonwheat globulin, albumin, and βamylase (food allergens) (p< 0.01, Fisher’s Ztest). This evidence suggests that in the past humans carried out selective breeding to reduce the expression of food plant genes encoding these allergenic proteins.

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Exiting the Anthropocene: Achieving personal and planetary health in the 21st century

Cited by 39 publications

References 131 publications

Vitality Revisited: The Evolving Concept of Flourishing and Its Relevance to Personal and Public Health

Vitality Revisited: The Evolving Concept of Flourishing and Its Relevance to Personal and Public Health

A short history from Karelia study to biodiversity and public health interventions

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