Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors

Thippaiah, Srinagesh Mannekote; Iyengar, Sloka; Vinod, K. Yaragudri

doi:10.3389/fpsyt.2021.636228

Cited by 10 publications

(3 citation statements)

References 126 publications

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“…Likewise, nearly 15% of undergraduate students who reported past-year cannabis use experienced adverse outcomes associated with cannabis use, including suicidal thoughts [ 15 ]. The dearth of literature examining the link between problematic cannabis use and suicidal thoughts and behaviors has led to inconsistent conclusions, with some studies suggesting that cannabis use specifically does not influence suicidal outcomes, while others highlighted the elevated risk [ 16 , 17 , 18 ]. Thus, further investigation into the potential role of problematic cannabis use in the etiopathogenesis of suicidal thoughts and behaviors is critical.…”

Section: Introductionmentioning

confidence: 99%

Examining Risk Factors in the Cannabis–Suicide Link: Considering Trauma and Impulsivity among University Students

Daneshmend

Stewart

Jarkas

et al. 2022

IJERPH

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Cannabis is a commonly used substance among university students that may have several negative health repercussions, including suicidal ideation (SI) and suicide attempts (SA). The factors that contribute to or help explain this relation remain uncertain. Earlier negative experiences, especially trauma encountered during early life, have been associated with the development of psychopathology upon later stressor encounters. In the current study, we examined the associations between SI and SA with problematic cannabis use among young adults and the role of earlier trauma experiences and trait impulsiveness in understanding this link. Among university students (N = 539), problematic cannabis use was moderately related to lifetime and past-12-months suicidal ideation and attempts. Impulsiveness mediated the relationship between problematic cannabis use and lifetime SI and SA. Moreover, previous life trauma moderated the relationship between problematic cannabis use and SA, such that the association between problematic cannabis use and SA was stronger among those who experienced high levels of trauma. These findings highlight behavioral and environmental factors that could predict suicide ideation and attempts among young cannabis users. Accordingly, trait impulsiveness and early trauma experiences should be considered, alongside problematic cannabis use, in suicide-risk detection and prevention strategies among young adults.

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Section: Introductionmentioning

confidence: 99%

Examining Risk Factors in the Cannabis–Suicide Link: Considering Trauma and Impulsivity among University Students

Daneshmend

Stewart

Jarkas

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…The endogenous cannabinoid or endocannabinoid system has been identified as playing a significant role in several psychiatric disorders, as well as in suicidal behaviour [142,143]. These effects appear to be mediated primarily through the cannabinoid type 1 (CB1) receptor, which is expressed at high levels in several key brain regions, including the prefrontal cortex and limbic system [144].…”

Section: E4 Cannabinoid Receptor Agonistsmentioning

confidence: 99%

Pharmacotherapy for the Secondary Prevention of Suicide: Leads from the Social Pain Hypothesis

Rajkumar¹

2022

Preprint

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Suicidal behaviour is a public health problem whose magnitude is both substantial and increasing. Since many individuals seek medical treatment following a suicide attempt, strategies aimed at reducing further attempts in this population are a valid and feasible secondary prevention approach. An evaluation of the available evidence suggests that existing treatment approaches have limited efficacy in this setting, highlighting the need for innovative approaches to suicide prevention. Existing research on the neurobiology of social pain has highlighted the importance of this phenomenon as a risk factor for suicide, and has also yielded several attractive targets for pharmacological preventive strategies. In this paper, the available evidence related to these targets is synthesized and critically evaluated. The way in which social pain is related to the “anti-suicidal” properties of recently approved treatments, such as ketamine and psilocybin, is also examined. Such strategies may be effective for the short-term reduction of suicidal ideation and behaviour in individuals who have made a suicide attempt suicide prevention, particularly in cases where social pain is identified as a contributory factor. These pharmacological approaches may be effective regardless of the presence or absence of a specific psychiatric diagnosis.

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“…THC is by far the most abundant and the most active cannabinoid in cannabis plants. This cannabinoid is a partial agonist of both CB1 and CB2 receptors, but has greater activity at CB1 subtypes, which is thought to account for its psychoactive effects producing changes in cognition, mood, or emotions ( Mannekote Thippaiah et al, 2021 ). Thereby, THC is used for its psychoactive effects, causing a feeling of euphoria and well-being.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Cannabis and Its Derivatives in Animals and Humans During Pregnancy and Breastfeeding

et al. 2022

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Cannabis is one of the most widely used illicit drugs during pregnancy and lactation. With the recent legalization of cannabis in many countries, health professionals are increasingly exposed to pregnant and breastfeeding women who are consuming cannabis on a regular basis as a solution for depression, anxiety, nausea, and pain. Cannabis consumption during pregnancy can induce negative birth outcomes such as reduced birth weight and increased risk of prematurity and admission to the neonatal intensive care unit. Yet, limited information is available regarding the pharmacokinetics of cannabis in the fetus and newborn exposed during pregnancy and lactation. Indeed, the official recommendations regarding the use of cannabis during these two critical development periods lack robust pharmacokinetics data and make it difficult for health professionals to guide their patients. Many clinical studies are currently evaluating the effects of cannabis on the brain development and base their groups mostly on questionnaires. These studies should be associated with pharmacokinetics studies to assess correlations between the infant brain development and the exposure to cannabis during pregnancy and breastfeeding. Our project aims to review the available data on the pharmacokinetics of cannabinoids in adults, neonates, and animals. If the available literature is abundant in adult humans and animals, there is still a lack of published data on the exposure of pregnant and lactating women and neonates. However, some of the published information causes concerns on the exposure and the potential effects of cannabis on fetuses and neonates. The safety of cannabis use for non-medical purpose during pregnancy and breastfeeding needs to be further characterized with proper pharmacokinetic studies in humans feasible in regions where cannabis has been legalized. Given the available data, significant transfer occurs to the fetus and the breastfed newborn with a theoretical risk of accumulation of products known to be biologically active.

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Exo- and Endo-cannabinoids in Depressive and Suicidal Behaviors

Cited by 10 publications

References 126 publications

Examining Risk Factors in the Cannabis–Suicide Link: Considering Trauma and Impulsivity among University Students

Examining Risk Factors in the Cannabis–Suicide Link: Considering Trauma and Impulsivity among University Students

Pharmacotherapy for the Secondary Prevention of Suicide: Leads from the Social Pain Hypothesis

Pharmacokinetics of Cannabis and Its Derivatives in Animals and Humans During Pregnancy and Breastfeeding

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