Exo ring opening in methyl pheophorbide a 132-amide derivatives under the action of amines

We have shown the possibility of intramolecular cyclization with the participation of the carboxyl group at position 15 of the chlorin macrocycle with a primary or secondary amide group at position 13 through the formation of an imide bond under the action of 2-Chloro-1-methylpyridinium iodide; the imide bond can be used to form a seven-membered exocycle. Using this reaction, we synthesized a number of cycloimide derivatives of chlorophyll a. The proposed synthetic route can be carried out if the substituent at the amide nitrogen atom has a hydroxyl, dimethylaminomethyl or vinyl group, which opens up possibilities for further chemical modification of the obtained derivatives.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Exo ring opening in methyl pheophorbide a 132-amide derivatives under the action of amines

Cited by 2 publications

References 53 publications

Synthesis of novel chlorophyll a derivatives bearing glucose moieties and estimation of their photocytotoxic activity

Synthesis of novel chlorophyll a derivatives bearing glucose moieties and estimation of their photocytotoxic activity

Intramolecular cyclization of 15-carboxy-13-amide derivatives of chlorin e₆ under the action of 2-Chloro-1-methylpyridinium iodide

Contact Info

Product

Resources

About

Exo ring opening in methyl pheophorbide a 132-amide derivatives under the action of amines

Cited by 2 publications

References 53 publications

Synthesis of novel chlorophyll a derivatives bearing glucose moieties and estimation of their photocytotoxic activity

Synthesis of novel chlorophyll a derivatives bearing glucose moieties and estimation of their photocytotoxic activity

Intramolecular cyclization of 15-carboxy-13-amide derivatives of chlorin e6 under the action of 2-Chloro-1-methylpyridinium iodide

Contact Info

Product

Resources

About

Intramolecular cyclization of 15-carboxy-13-amide derivatives of chlorin e₆ under the action of 2-Chloro-1-methylpyridinium iodide