Exocellular products from Bifidobacterium adolescentis as immunomodifiers in the lymphoproliferative responses of mouse splenocytes

Abstract

Extracts of exocellular products from Bifidobacterium adolescentis and their fractions were tested as immunomodifiers of the murine lymphoproliferative response. The extracts induced a dose dependent blastogenic activation which was higher for the fractions rich in polysacharides. When interacting with lectins, neither the extracts nor the protein‐rich fractions produced any effect on the lymphoproliferative response. The carbohydrate‐rich fractions stimulated DNA synthesis in LPS‐sensitive B lymphocytes but decreased it in Con A‐sensitive T lymphocytes.

Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212

“…Bifidobacteria and other lactic acid bacteria can stimulate immune function (Kado-Oka et al, 1991;Lee et al, 1993;Gomez et al, 1998) and enhance the antitumor activity of the host (Fernandes and Shahani, 1990;Sekine et al, 1994;Rafter, 1995;Sekine et al, 1995). Here, we measured the anticancer effect of B. adolescentis SPM0212 via growth inhibition of Caco-2, HT-29, and SW 480 cells.…”

Food and Health Applications of Exopolysaccharides produced by Lactic acid Bacteria

“…Few studies also reveal immunomodulating, and antitumor activities of EPS [62,79,80]. The slime produced by B. adolescentis had immunomodifying effects on mouse splennocytes [81]. Kitazawa et al [82] showed that the slime-forming Lc.…”