Exocrine and endocrine functions of the pancreas in the diabetes mellitus and chronic pancreatitis

Yamagata, Shoichi; Gotō, Yoshio; Takebe, Takaaki; Koizumi, Haruo; Ohomiya, M.

doi:10.1007/bf02780113

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Vacca et al (1964) have suggested that the frequency of exocrine pancreatic abnormality is related not to the duration of the disease, but to the age of the diabetic patients, although studies of exocrine pancreatic function in non-diabetic patients have shown no deterioration in function with age (Rosenberg et al, 1966;Delachaume-Salem and Sarles, 1970). Other studies have also failed to show any relationship between exocrine pancreatic dysfunction and the duration of the diabetes (Yamagata et al, 1969;Domschke et al, 1975), except that Drewes (1969) found less severe exocrine pancreatic dysfunction in newly diagnosed juvenile-onset diabetics than in diabetics with disease for many years.…”

Section: Discussionmentioning

confidence: 98%

“…Abnormal exocrine pancreatic function has been reported in patients with juvenile-onset and maturityonset diabetes mellitus (Jones et al, 1925;Diamond and Siegel, 1940;Pollard et al, 1943;Chey et al, 1963;Vacca et al, 1964;Bock et al, 1967;Drewes, 1969;Yamagata et al, 1969; Baron and Nabarro, 1973;Domschke et a!., 1975). Neither the frequency nor the cause of the pancreatic dysfunction in the insulin-dependent diabetics has been fully defined.…”

mentioning

confidence: 99%

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Exocrine pancreatic function in juvenile-onset diabetes mellitus.

Frier¹,

Saunders²,

Wormsley³

et al. 1976

Gut

167

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Hepatocellular carcinoma is an aggressive cancer with poor prognosis. Fibroblast growth factor 19, a member of the fibroblast growth factor family, is a ligand for fibroblast growth factor receptor 4. Moreover, it plays a crucial role in the progression of hepatocellular carcinoma. ASP5878 is a novel inhibitor of fibroblast growth factor receptors 1, 2, 3, and 4 that is under development. It inhibits fibroblast growth factor receptor 4 kinase activity with an IC 50 of 3.5 nmol/L. ASP5878 potently suppressed the growth of the fibroblast growth factor 19-expressing hepatocellular carcinoma cell lines Hep3B2

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Exocrine pancreatic function in juvenile-onset diabetes mellitus.

Frier¹,

Saunders²,

Wormsley³

et al. 1976

Gut

167

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“…9. 12, 23] the degree of exocrine pancreatic insuffi ciency is dependent on the duration of the diabetes or whether there is a correlation with the presence or absence of late diabetic complications [29].…”

Section: Introductionmentioning

confidence: 99%

Exocrine Pancreatic Function in Insulin-Dependent Diabetes mellitus

et al. 1982

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Exocrine pancreatic function was studied in patients with long-standing insulin-dependent diabetes mellitus using the secretin-pancreozymin test (n = 53), and estimation of immunoreactive trypsin (n = 43) and pancreatic isoamylase (n = 43). The secretin-pancreozymin test was abnormal in 23 patients (43 %). The abnormalities found were a decreased output of lipase (37%), amylase (36%) or trypsin (26%) and bicarbonate (15%). Serum immunoreactive trypsin was below normal in only 6 (14%) and pancreatic isoamylase in 29 (67%) patients. There was no correlation between impairment of the secretin-pancreozymin test and decreased serum enzyme levels. It is concluded that an impairment of exocrine pancreatic function is frequent in insulin-dependent diabetics but that a decrease in serum enzymes, especially in pancreatic isoamylase, does not reflect an impairment of pancreatic function in these patients.

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“…For instance, in insulin-dependent diabetes mellitus the exocrine pancreatic function is frequently impaired [7,14,15,16,24,37], and insulin regulates the synthesis of amylase at the level of transcription [31]. Conversely, a dependency of B-cell function on the exo crine pancreatic function has also been sup posed [2,8,19,28], The development of pan creatogenic diabetes is a characteristic feature of advanced chronic pancreatitis [34], and the administration of the bioactive carboxy terminal decapeptide of cholecystokinin has a trophic influence on the endocrine pan creas, in addition to its stimulating effect on pancreatic juice secretion [6], From these thoughts it appeared appropriate to study whether or not there are signs of impaired secretion of pancreatic islet hormones and the state of glucose regulation in a mamma lian species more closely related to man, after long-term duct occlusion and pancreas atro phy.…”

mentioning

confidence: 99%

Influence of Pancreatic Duct Occlusion on Islet Hormones in Peripheral and Portal Plasma and in the Pancreas of the Mini-Pig

Schwille¹,

Engelhardt²,

Volkholz

et al. 1985

Eur Surg Res

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In a total of 18 ‘Göttingen’ mini-pigs we studied basal glucose in the peripheral plasma, and the hormones insulin, glucagon, and somatostatin in the peripheral and portal plasma, as well as in extracts of pancreatic tissue, both in animals subjected to pancreatic duct occlusion with prolamine (Occ pigs) 9 months previously and in controls. Additionally, in the pancreas the relative frequency of A-, B-, D- and PP-cells was determined by immunocytochemistry. In peripheral blood of Occ pigs glucose, insulin, and somatostatin were unchanged, while glucagon was decreased. Also after occlusion the portal plasma revealed an increase in insulin but unchanged glucagon and somatostatin, while in the pancreatic tissue insulin and glucagon were statistically unchanged, but somatostatin was reduced. The relative frequency of A-, B-, D- and PP-cells in the pancreatic islets was comparable in both control and Occ pigs. It is concluded that also in the pig pancreatic duct occlusion leads to atrophy of the exocrine pancreas, but leaves undisturbed basal blood glucose, insulin, glucagon and islet cells.

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Exocrine and endocrine functions of the pancreas in the diabetes mellitus and chronic pancreatitis

Cited by 3 publications

References 5 publications

Exocrine pancreatic function in juvenile-onset diabetes mellitus.

Exocrine pancreatic function in juvenile-onset diabetes mellitus.

Exocrine Pancreatic Function in Insulin-Dependent Diabetes mellitus

Influence of Pancreatic Duct Occlusion on Islet Hormones in Peripheral and Portal Plasma and in the Pancreas of the Mini-Pig

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