Exocrine pancreatic insufficiency and its consequences on physical development and metabolism in children and adolescents with type�1�diabetes mellitus

Laaß, Martin W.; Henker, J; Thamm, K.; Neumeister, Volker; Kuhlisch, Eberhard

doi:10.1007/s00431-004-1501-2

Cited by 12 publications

(13 citation statements)

References 5 publications

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“… Total excludes studies by Nunes et al 7 (no DM subtypes), Ewald et al 5 (percentage for <200 μg/g not available), Hahn et al, 16 Laass et al, 6 and Vesterhus et al 14 (percentage for <100 μg/g unavailable). * P values for types 1 and 2 DM versus controls are <0.00001 and <0.00001 for <200 and <100 μg/g, respectively. …”

Section: Figurementioning

confidence: 99%

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Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy

et al. 2016

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Objective Abnormalities in exocrine pancreatic function have been reported in diabetes mellitus (DM). We reviewed published literature to determine the nature of structural and functional alterations in the exocrine pancreas in DM. Methods We identified and abstracted data from original studies (n = 50) describing morphological, structural, and functional changes in the exocrine pancreas in types 1 and 2 DM. Results Pancreatic weight and volume are markedly lower in type 1 DM (P < 0.005) with insignificant decrease in type 2 DM compared with age-, sex-, and body mass index–matched controls. Pancreatic histopathological changes seen in most subjects with DM at autopsy (n = 7 studies, 1272 autopsies) include mild-to-marked interacinar fibrosis, scant inflammatory infiltrate, no pancreatic ductal changes, and hyalinization of arteries. In subjects with DM, pooled prevalence of decreased fecal elastase 1 (<200 μg/g) is higher, coefficient of fat absorption is near normal (mean, 91%–94%), and pancreatic exocrine dysfunction is nonprogressive over time. Diabetes mellitus is asymptomatic in regard to the exocrine pancreas. Conclusions In types 1 and 2 DM, moderate-to-severe subclinical pancreatic fibrosis and modest exocrine dysfunction occurs in the absence of clinical or histopathological evidence of chronic pancreatitis. We call this novel entity “diabetic exocrine pancreatopathy.”

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy

et al. 2016

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“…Symptoms are weight loss, failure to thrive and associated symptoms from nutritional deficits. Most of these patients who are symptomatic require medical treatment [1][2][3]. Oral pancreatic enzyme supplements are essential drugs for these patients.…”

Section: Properties Of Different Pancreatin Preparations Used In Pancmentioning

confidence: 99%

Properties of different pancreatin preparations used in pancreatic exocrine insufficiency

Löhr¹,

Hummel

Pirilis

et al. 2009

European Journal of Gastroenterology &Amp; Hepatology

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“…Среди взрослых пациентов этот показатель достигает почти 60%[11]. Педиатры из Германии обнаружили умеренную экзокринную недостаточность у 35% детей с СД, тяжелую -у 10%[8]. В исследовании C. Sierra и соавт [15],.…”

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Exocrine Pancreatic Insufficiency in Children With Type 1 Diabetes Mellitus: A New Problem of Pediatric Gastroenterology

Нижевич¹,

Якупова²,

Малиевский³

et al. 2013

Vopr. sovr. pediatr.

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В статье представлены данные о наличии у некоторых детей, страдающих сахарным диабетом 1-го типа, экзокринной панкреатической недостаточности. Показано, что применение заместительной ферментотерапии панкреатическими энзимами способствует ликвидации синдрома нарушенного переваривания пищи (мальдигестии) у данной группы детей. В статье также оценено значение определения фекальной эластазы 1 в качестве диагностического стандарта экзокринной панкреатической недостаточности у детей с сахарным диабетом 1-го типа.

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Exocrine pancreatic insufficiency and its consequences on physical development and metabolism in children and adolescents with type�1�diabetes mellitus

Cited by 12 publications

References 5 publications

Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy

Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy

Properties of different pancreatin preparations used in pancreatic exocrine insufficiency

Exocrine Pancreatic Insufficiency in Children With Type 1 Diabetes Mellitus: A New Problem of Pediatric Gastroenterology

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