“…(iii) act as vectors for possibly life-threatening diseases such as plague, leishmaniansis especially visceral leishmaniansis (fleas), typhus (lice), malaria, yellow fever, dengue and Zika fever (mosquitoes), lyme disease (ticks), and skin and allergic diseases (mites). 2 As a consequence, men have fought insects from very early times, 1,3 and crop protection can be estimated at the cost of $6 billions/year. 2 Fumigation with sulfur was first used (1000 BC), followed by natural extract of plants (such as pyrethrins, in the Middle Ages, 3,4 Figure 1), inorganic compounds [lead arsenate (PbHAsO4), cryolite (Na3AlF6) and borax (Na2B4O7)], organic compounds (DDT, 1939) 2,5,6 and bacterial, fungal and viral agents as well as DNA insecticides.…”