Exoelectrogenic capacity of host microbiota predicts lymphocyte recruitment to the gut

Ericsson, Aaron C.; Davis, Daniel R.; Franklin, Craig L.; Hagan, Catherine E.

doi:10.1152/physiolgenomics.00010.2015

Cited by 21 publications

(22 citation statements)

References 42 publications

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“…Microbial DNA was extracted as previously described (Ericsson et al, 2015). Briefly, fecal samples were collected into 800 µL of lysis buffer (500 mM NaCl, 50 mM tris-HCl, 50 mM EDTA, and 4% SDS), homogenized in a Qiagen Tissuelyser II (Valencia CA), and incubated at 70°C for 20 min.…”

Section: Methodsmentioning

confidence: 99%

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto

Ito

Pineda

et al. 2016

eLife

366

275

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The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy aging. Here we show that 3 months of rapamycin treatment is sufficient to increase life expectancy by up to 60% and improve measures of healthspan in middle-aged mice. This transient treatment is also associated with a remodeling of the microbiome, including dramatically increased prevalence of segmented filamentous bacteria in the small intestine. We also define a dose in female mice that does not extend lifespan, but is associated with a striking shift in cancer prevalence toward aggressive hematopoietic cancers and away from non-hematopoietic malignancies. These data suggest that a short-term rapamycin treatment late in life has persistent effects that can robustly delay aging, influence cancer prevalence, and modulate the microbiome.DOI: http://dx.doi.org/10.7554/eLife.16351.001

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Section: Methodsmentioning

confidence: 99%

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto

Ito

Pineda

et al. 2016

eLife

366

275

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“…Another intriguing concept is the possibility that microorganisms in the human gut may electrically interact with cells in the gut epithelium (Ericsson et al, 2015). This, and the strong possibility of microbe-microbe electrical communication in this anaerobic environment, suggests that the human gut may be one of the next exciting frontiers in the study of e-communities.…”

Section: Electrically Connected Microbial Communities Dr Lovleymentioning

confidence: 99%

“…As discussed below, other types of microbial electrical connectors seem possible. The proposed potential for electrical interactions between microbes and human cells (Ericsson et al, 2015) demonstrates the need to think broadly in the early stages of e-community research.…”

Section: Introductionmentioning

confidence: 99%

Happy together: microbial communities that hook up to swap electrons

2016

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The discovery of direct interspecies electron transfer (DIET) and cable bacteria has demonstrated that microbial cells can exchange electrons over long distances (μm-cm) through electrical connections. For example, in the presence of cable bacteria electrons are rapidly transported over centimeter distances, coupling the oxidation of reduced sulfur compounds in anoxic sediments to oxygen reduction in overlying surficial sediments. Bacteria and archaea wired for DIET are found in anaerobic methane-producing and methane-consuming communities. Electrical connections between gut microbes and host cells have also been proposed. Iterative environmental and defined culture studies on methanogenic communities revealed the importance of electrically conductive pili and c-type cytochromes in natural electrical grids, and demonstrated that conductive carbon materials and magnetite can substitute for these biological connectors to facilitate DIET. This understanding has led to strategies to enhance and stabilize anaerobic digestion. Key unknowns warranting further investigation include elucidation of the archaeal electrical connections facilitating DIET-based methane production and consumption; and the mechanisms for long-range electron transfer through cable bacteria. A better understanding of mechanisms for cell-to-cell electron transfer could facilitate the hunt for additional electrically connected microbial communities with omics approaches and could advance spin-off applications such as the development of sustainable bioelectronics materials and bioelectrochemical technologies.

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“…Shewanella species shuttle electrons across their membranes during anaerobic respiration, resulting in electrical activity within their biofilms and the transformation of insoluble compounds to bioavailable ones. Interestingly, biofilms with electrical activity have been documented to influence host cellular responses [13]. These bacteria make stable biofilms and because they can respire almost any compound, they likely represent important symbionts of animals as well.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of a Shewanella Phage–Host System from the Gut of the Tunicate, Ciona intestinalis

Leigh

Karrer

Cannon

et al. 2017

Viruses

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Outnumbering all other biological entities on earth, bacteriophages (phages) play critical roles in structuring microbial communities through bacterial infection and subsequent lysis, as well as through horizontal gene transfer. While numerous studies have examined the effects of phages on free-living bacterial cells, much less is known regarding the role of phage infection in host-associated biofilms, which help to stabilize adherent microbial communities. Here we report the cultivation and characterization of a novel strain of Shewanella fidelis from the gut of the marine tunicate Ciona intestinalis, inducible prophages from the S. fidelis genome, and a strain-specific lytic phage recovered from surrounding seawater. In vitro biofilm assays demonstrated that lytic phage infection affects biofilm formation in a process likely influenced by the accumulation and integration of the extracellular DNA released during cell lysis, similar to the mechanism that has been previously shown for prophage induction.

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Exoelectrogenic capacity of host microbiota predicts lymphocyte recruitment to the gut

Abstract: Ericsson AC, Davis DJ, Franklin CL, Hagan CE. Exoelectrogenic capacity of host microbiota predicts lymphocyte recruitment to the gut.

Cited by 21 publications

References 42 publications

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Happy together: microbial communities that hook up to swap electrons

Isolation and Characterization of a Shewanella Phage–Host System from the Gut of the Tunicate, Ciona intestinalis

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