Exogenous acellular synovial fluid as a new therapeutic option in tissue engineering and regenerative medicine

Oryan, Ahmad; Moshiri, Ali

doi:10.13172/2050-2303-2-3-439

Cited by 2 publications

(11 citation statements)

References 89 publications

(247 reference statements)

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“…Tissue engineering is another option which has been introduced in the last decade and currently it is the final option in managing large and massive tendon and ligament injuries [22][23][24][25][26][27][28][29][30][31][32]. Tissue engineering is defined as "a process that affects the structure and architecture of any viable and nonviable tissue with the aim to increase the effectiveness of the construct in biologic environments" [12].…”

Section: Tissue Engineeringmentioning

confidence: 99%

“…Scaffolds are the most important part of tissue engineering because they have many applications and without them application of promotive factors and stem cells have low clinical value because their long term availability without attachment to the scaffolds is questionable [12,[22][23][24][25][26][27][28][29][30][31][32]. Tissue scaffolds have several duties but their major role is to provide a suitable environment for cell attachment, migration, proliferation and matrix remodeling and regeneration [12].…”

Section: Scaffoldsmentioning

confidence: 99%

“…Tissue scaffolds have several duties but their major role is to provide a suitable environment for cell attachment, migration, proliferation and matrix remodeling and regeneration [12]. In addition, tissue scaffolds have been used in drug delivery, vehicle for healing promotive factors and stem cells and also as tissue filler [24][25][26][27][28][29][30][31][32]. Based on their stiffness, scaffolds could be divided into three major categories including hard, soft and hybrid scaffolds [12,24].…”

Section: Scaffoldsmentioning

confidence: 99%

“…''Healing Promotive Factors'' is another category of tissue engineering [12,30,31]. These are basically divided into four categories including glycosaminoglycans, growth factors, pro-inflammatory mediators and healing agents [12,30,31].…”

Section: Healing Promotive Factorsmentioning

confidence: 99%

“…All these available options have their own significant limitations [3]. Tissue engineering is a newer option and is divided into four categories of scaffold, healing promotive factors, stem cells and gene therapy [22][23][24][25][26][27][28][29][30][31][32]. Using each or a combination of them have provided the new insights in orthopedic surgery [12,24,[30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Moshiri¹,

Oryan²

2013

J Sports Med Doping Stud 2013

102

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Tendons transmit forces from muscle to bone and provide the joint function and ligaments transmit forces from bone to bone and provide joint stability. Tendon and ligament injuries have high incidence and management of tendon and ligament injuries is technically demanding because the healing response of these soft connective tissues is low. In addition, number of the available options to be considered as tissue replacement for large defects is low and healing of tendon and ligaments is faced to significant limitations. Among the available options, autografts are still gold standard but all the auto-allo and xenografts have their own limitations. Tissue engineering is a newer option but it is still primitive to be applicable extensively, in clinical setting. Tissue engineering could be divided into four categories including scaffolds, healing promotive factors, stem cells and gene therapy. To be able to have a good judgment regarding the management of tendon and ligament injuries, it is crucial to have a basic knowledge of tendon and ligament healing and regeneration. In this review, we discussed various types of tendon and ligament injuries and their incidence, and introduced the available and future options in managing large and massive tendon and ligament injuries. We specifically discussed the tissue engineering and it's advantageous and disadvantageous. To give a better clarification for the readers, we described different phases and cascades of tendon and ligament healing, modeling and remodeling, host-graft interaction after implantation of the graft and various types of prosthetic implants and finally provided some suggestions for the future investigations.

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Section: Tissue Engineeringmentioning

confidence: 99%

Section: Scaffoldsmentioning

confidence: 99%

Section: Scaffoldsmentioning

confidence: 99%

Section: Healing Promotive Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Moshiri¹,

Oryan²

2013

J Sports Med Doping Stud 2013

102

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Burn wound healing: present concepts, treatment strategies and future directions

2017

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Burns are the most extensive forms of soft tissue injuries occasionally resulting in extensive and deep wounds and death. Burns can lead to severe mental and emotional distress, because of excessive scarring and skin contractures. Treatment of burns has always been a difficult medical problem and many different methods have been used to treat such injuries, locally. Biofilms are a collection of microorganisms that delay wound healing. One of the new methods of prevention and treatment of burn wound infections is application of antimicrobials, which act on biofilms and prevent the wound infection. Biofilm initiates a persistent, low-grade, inflammatory response, impairing both the epithelialisation and granulation tissue formation. Skin grafts have been shown to dramatically reduce deaths from infection. However, grafting has considerable limitations. Such injuries are long-lasting and many patients suffer from chronic pain for a long time. Tissue engineering is a new approach in reducing the limitations of conventional treatments and producing a supply of immunologically tolerant artificial tissue, leading to a permanent solution for damaged tissues; such criteria make it a cost-effective and reliable treatment modality. To overcome the present limitations of burn wound healing, knowledge about the latest findings regarding healing mechanisms is important. Here the authors discuss the most important events regarding burn wound healing and review the latest treatment strategies that have been used for burn wounds from in vitro to clinical levels. Finally, we discuss the role of tissue engineering and regenerative medicine in the future of burn wound healing, modelling and remodelling.

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Exogenous acellular synovial fluid as a new therapeutic option in tissue engineering and regenerative medicine

Cited by 2 publications

References 89 publications

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Burn wound healing: present concepts, treatment strategies and future directions

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