Exogenous Adenosine 5′-triphosphate does not Improve Survival in Rats with Acute Liver Failure

Becker, Erin P.; Sun, Dongfeng; Minuk, Gerald Y.

doi:10.1007/s10620-007-9940-z

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Moreover, it has been established that hepatocellular glycogen level is a potentially important and manageable factor in maintaining hepatocellular integrity and function by generating ATP [27][28][29]. Once glycogen is consumed, ATP depletion rapidly develops, leading to a series of events that eventually cause irreversible cell injury and necrosis [30,31].…”

Section: Discussionmentioning

confidence: 99%

Effects of Bicyclol on Liver Regeneration After Partial Hepatectomy in Rats

Yao

Zhao

et al. 2009

Dig Dis Sci

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Bicyclol is a synthetic antihepatitis drug with antioxidative property. The present study was performed to investigate the effect of bicyclol on liver regeneration after partial hepatectomy in rats. Bicyclol (300 mg/kg) was given to rats subjected to 70% hepatectomy three times before operation. At 6, 24, and 48 h after resection, samples were collected for the measurement of serum alanine aminotransferase (ALT), total bilirubin (TBil), hepatic glycogen, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH). Moreover, liver regeneration rate, proliferating cell nuclear antigen (PCNA) labeling, proliferation index, and histopathological examination were evaluated at 48 h after hepatectomy. As a result, bicyclol significantly increased regeneration rate, mitotic index (MI), PCNA labeling index, and proliferation index in PH rats. Additionally, bicyclol remarkably inhibited the elevation of serum ALT and TBil levels, alleviated the formation of liver MDA, restored impaired antioxidant SOD and GSH, increased hepatic glycogen content, and also attenuated hepatic vacuolar degeneration. These results suggested that bicyclol had a beneficial effect on liver regenerative capacity of the remnant liver tissue after hepatectomy, probably due to its antioxidative property.

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Section: Discussionmentioning

confidence: 99%

Effects of Bicyclol on Liver Regeneration After Partial Hepatectomy in Rats

Yao

Zhao

et al. 2009

Dig Dis Sci

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“…6,36,37 Interestingly, early recent work with rats with Dgalactosamine-induced fulminant liver failure showed that exogenous ATP did not improve survival, and at high doses it was detrimental to survival. 38 POTENTIAL TREATMENTS FOR ALF Now that the different modes of cell death in ALF have been well characterized, the opportunity arises to interrupt these pathways in the treatment for ALF. Several caspase inhibitors have shown promising responses by improving survival in mice following induction of ALF 39,40 ; however, perhaps because of the broad effects of these medications and the significant risk of mortality in the target population, these inhibitors have yet to be tested in humans with ALF.…”

Section: Necroapoptosismentioning

confidence: 99%

Acute Liver Failure: Mechanisms of Hepatocyte Injury and Regeneration

Rutherford¹,

Chung²

2008

Semin Liver Dis

107

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Acute liver failure (ALF) occurs when the extent of hepatocyte death exceeds the liver's regenerative capacity. Despite vast differences in causes, the mode of cell death typically follows one of two patterns: necrosis or apoptosis. Necrosis and apoptosis have traditionally been considered separate entities within various etiologies of ALF; however, there is increasing evidence that they are alternative outcomes of the same initiating factors and signaling pathways, a process known as necroapoptosis. Here we review mechanisms of liver cell injury in ALF, including evolving knowledge of pathways leading to apoptosis, necrosis, and necroapoptosis, as well as how these pathways are potential therapeutic targets in ALF. We also discuss hepatic regeneration and the cytokines and growth factors involved in both the replication of differentiated hepatocytes as well as activation of intrahepatic progenitor cells, two pathways of hepatocyte regeneration that are dependent on the type and extent of hepatic insult in ALF.

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Exogenous Adenosine 5′-triphosphate does not Improve Survival in Rats with Acute Liver Failure

Cited by 2 publications

References 27 publications

Effects of Bicyclol on Liver Regeneration After Partial Hepatectomy in Rats

Effects of Bicyclol on Liver Regeneration After Partial Hepatectomy in Rats

Acute Liver Failure: Mechanisms of Hepatocyte Injury and Regeneration

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