Exogenous alpha-linolenic acid and Vibrio parahaemolyticus induce EPA and DHA levels mediated by delta-6 desaturase to enhance shrimp immunity

Chen, Zeyan; Kong, Yonghui; Huang, Zishu; Zheng, Xiaoyu; Zheng, Zhihong; Yao, Defu; Yang, Shen; Zhang, Yueling; Aweya, Jude Juventus

doi:10.1016/j.ijbiomac.2023.128583

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…3.8 PRV XJ delgE/gI/TK regulates inflammation through the PI3K/Akt signaling pathway Metabolites such as 5Z, 8Z, 11Z, 14Z, 17Z-eicosapentaenoic acid, 7,10,13, 16-docosatetraenoic acid, 3-hydroxycaprylate, glutathione, L-histidine and L-lysine are involved in the regulation of inflammatory response (Chen et al, 2024), suggesting that PRV XJ delgE/gI/TK immunization may regulate inflammatory response through metabolites. Subsequently, we performed a co-expression network analysis of important metabolites and genes associated with inflammatory response between the immunization-challenged group and the challenged group.…”

Section: Prv Xj Delge/gi/tk Regulates Inflammation By Inducing Fatty ...mentioning

confidence: 99%

Transcriptome and metabolome analysis reveals PRV XJ delgE/gI/TK protects intracranially infected mice from death by regulating the inflammation

Xu,

Zhang,

Tao

et al. 2024

Front. Microbiol.

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Pseudorabies virus can cause inflammation in the central nervous system and neurological symptoms. To further investigate the protective mechanism of PRV XJ delgE/gI/TK in the central nervous system, an intracranial PRV-infection mice model was developed. The results demonstrated that immunization with PRV XJ delgE/gI/TK successfully prevented death caused by PRV-intracranial infection. Subsequently, the brains were collected for transcriptome and metabolome analysis. GO and KEGG enrichment analysis indicated that the differentially expressed genes were primarily enriched in pathways such as TNF, NOD-like receptor, JAK–STAT, MAPK, IL-17 and apoptosis signaling. Metabolomics analysis revealed that the differential metabolites were mainly associated with pathways such as fatty acid degradation, arachidonic acid metabolism, linoleic acid metabolism and unsaturated fatty acid biosynthesis. The combined analysis of metabolites and differentially expressed genes revealed a strong correlation between the differential metabolites and TNF, PI3K, and MAPK signaling pathways. Anti-inflammatory metabolites have been shown to inhibit the inflammatory response and prevent mouse death caused by PRV infection. Notably, when glutathione was injected intracranially and dihydroartemisinin was injected intraperitoneally, complete protection against PRV-induced death in mice was observed. Moreover, PRV activates the PI3K/AKT signaling pathway. In conclusion, our study demonstrates that PRV XJ delgE/gI/TK can protects intracranially infected mice from death by regulating various metabolites with anti-inflammatory functions post-immunization.

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Section: Prv Xj Delge/gi/tk Regulates Inflammation By Inducing Fatty ...mentioning

confidence: 99%

Transcriptome and metabolome analysis reveals PRV XJ delgE/gI/TK protects intracranially infected mice from death by regulating the inflammation

Xu,

Zhang,

Tao

et al. 2024

Front. Microbiol.

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An improved recirculatory system model for culture of sludge worm: A cleaner innovative choice

Prakash,

Munilkumar,

Narsale

et al. 2024

Environmental Technology & Innovation

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Influence of processing factors on quality and heterocyclic amines content in roast mutton granules

Zhang,

Liu,

Cao

et al. 2025

Journal of Food Composition and Analysis

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Exogenous alpha-linolenic acid and Vibrio parahaemolyticus induce EPA and DHA levels mediated by delta-6 desaturase to enhance shrimp immunity

Cited by 5 publications

References 54 publications

Transcriptome and metabolome analysis reveals PRV XJ delgE/gI/TK protects intracranially infected mice from death by regulating the inflammation

Transcriptome and metabolome analysis reveals PRV XJ delgE/gI/TK protects intracranially infected mice from death by regulating the inflammation

An improved recirculatory system model for culture of sludge worm: A cleaner innovative choice

Influence of processing factors on quality and heterocyclic amines content in roast mutton granules

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