Exogenous dehydroisoandrosterone sulfate reverses the dendritic changes of the central neurons in aging male rats

Chen, Jeng-Rung; Tseng, Guo‐Fang; Wang, Yueh-Jan; Wang, Tsyr-Jiuan

doi:10.1016/j.exger.2014.06.010

Cited by 11 publications

(9 citation statements)

References 65 publications

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“…In the present work, using a large number of rats (15 young and 27 old) we showed that, on average, older animals have shorter apical dendritic arborizations in dorsal HPC neurons (DG granules and CA1 and CA3 pyramids) but similar apical dendritic trees in mPFC neurons (Cg/PL and IL layers II/III pyramids) when compared to younger animals. These findings are in line with most previous studies that analyzed one or the other region (HPC 42–47 ; mPFC 48–50 ) and might suggest that the frontal regions might be less affected by the aging process or that age-related changes in neuronal morphology appear later in the mPFC. This is partly corroborated by the fact that age-related apical dendritic retraction in the mPFC was only reported in one study 51 .…”

Section: Discussionsupporting

confidence: 92%

Structural and molecular correlates of cognitive aging in the rat

Mota

Taipa

Neves

et al. 2019

Sci Rep

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Aging is associated with cognitive decline. Herein, we studied a large cohort of old age and young adult male rats and confirmed that, as a group, old rats display poorer spatial learning and behavioral flexibility than younger adults. Surprisingly, when animals were clustered as good and bad performers, our data revealed that while in younger animals better cognitive performance was associated with longer dendritic trees and increased levels of synaptic markers in the hippocampus and prefrontal cortex, the opposite was found in the older group, in which better performance was associated with shorter dendrites and lower levels of synaptic markers. Additionally, in old, but not young individuals, worse performance correlated with increased levels of BDNF and the autophagy substrate p62, but decreased levels of the autophagy complex protein LC3. In summary, while for younger individuals “bigger is better”, “smaller is better” is a more appropriate aphorism for older subjects.

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Section: Discussionsupporting

confidence: 92%

Structural and molecular correlates of cognitive aging in the rat

Mota

Taipa

Neves

et al. 2019

Sci Rep

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“…The biological mechanisms underlying the association between rs17268988 genotype and intra‐individual reaction time variability will also warrant investigation. There is some evidence that DHEA(S) levels are associated with decline in cognitive performance across aging in humans (Maggio et al., 2015) and rodents (Chen, Tseng, Wang, & Wang, 2014). At the neuroanatomical level, intra‐individual variability in reaction time has been most robustly associated with white matter volume (Nilsson, Thomas, O'Brien, & Gallagher, 2014; Walhovd & Fjell, 2007); STS is expressed within the white matter of the human brain, albeit at relatively low levels (Steckelbroeck et al., 2004; Stergiakouli et al., 2011).…”

Section: Discussionmentioning

confidence: 99%

“…The biological mechanisms underlying the association between rs17268988 genotype and intra-individual reaction time variability will also warrant investigation. There is some evidence that DHEA(S) levels are associated with decline in cognitive performance across aging in humans (Maggio et al, 2015) and rodents (Chen, Tseng, Wang, & Wang, 2014).…”

Section: C-allele Carriers (N = 103) G-allele Carriers (N = 28) Statimentioning

confidence: 99%

A genetic variant within STS previously associated with inattention in boys with attention deficit hyperactivity disorder is associated with enhanced cognition in healthy adult males

et al. 2017

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IntroductionThe enzyme steroid sulfatase (STS) converts sulfated steroids to their non‐sulfated forms. Deficiency for this enzyme is associated with inattention but preserved response control. The polymorphism rs17268988 within the X‐linked STS gene is associated with inattentive, but not other, symptoms in boys with attention deficit hyperactivity disorder (ADHD).MethodsWe initially tested whether rs17268988 genotype was associated with attention, response control, and underlying aspects of cognition, using questionnaires and neuropsychological tasks, in two independent cohorts of healthy adult males. In an additional analysis based upon existing data, the performance of mice with genetic or pharmacological manipulations of the STS axis under attentionally demanding conditions was investigated.ResultsG‐allele carriers at rs17268988 exhibited reduced reaction time, enhanced attention, and reduced reaction time variability relative to C‐allele carriers. Mice with genetic or pharmacological manipulations of the STS axis were shown to have perturbed reaction time variability.DiscussionOur findings provide additional support for an association between rs17268988 genotype and attention, which may be partially mediated by reaction time variability; they also indicate that, in contrast to the situation in boys with ADHD, in healthy men, the G‐allele at rs17268988 is associated with enhanced cognition. As reaction time variability is a predictor of well‐being, rs17268988 genotype may represent a biomarker for long‐term health.

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“…DHEA also functions at the other end of the aging process. For example, in rodents, replacement of DHEA reverses age-related dendritic changes in the CNS (6). Overall, in older humans, low DHEA levels have been associated with increased mortality in men, though in women this relationship is less clearly characterized (7).…”

Section: Introductionmentioning

confidence: 99%

Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth

Dismukes

Meyer

Shirtcliff

et al. 2016

Endocrine Connections

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The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging.

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Exogenous dehydroisoandrosterone sulfate reverses the dendritic changes of the central neurons in aging male rats

Cited by 11 publications

References 65 publications

Structural and molecular correlates of cognitive aging in the rat

Structural and molecular correlates of cognitive aging in the rat

A genetic variant within STS previously associated with inattention in boys with attention deficit hyperactivity disorder is associated with enhanced cognition in healthy adult males

Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth

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