Exogenous dopamine induces dehydroepiandrosterone sulfotransferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats

Shao, Xueyan; Li, Jian; Wang, Siyuan; Chen, Guangping; Xu, Jiaojiao; Ji, Xiwei; Li, Liang; Lu, Wei; Zhou, Tianyan

doi:10.1016/j.dmpk.2014.10.003

Cited by 3 publications

(1 citation statement)

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“…The protein concentration was determined using a BCA protein assay, and Western blot analysis was performed as described in a previous study [31] . Equal amounts (10 μg for β-actin and 30 μg for EST) of total protein were separated by SDS 10%-w/v polyacrylamide gel electrophoresis and transferred to PVDF membranes.…”

Section: Cytosol Preparation and Western Blot Analysismentioning

confidence: 99%

Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen

Wang

Hao

et al. 2016

Acta Pharmacol Sin

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Section: Cytosol Preparation and Western Blot Analysismentioning

confidence: 99%

Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen

Wang

Hao

et al. 2016

Acta Pharmacol Sin

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Testosterone, DHEA and DHEA-S in patients with schizophrenia: A systematic review and meta-analysis

Misiak

Frydecka

Loska

et al. 2018

Psychoneuroendocrinology

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Repeated restraint stress upregulates rat sulfotransferase 1A1

Balyan

Zhao

et al. 2018

Journal of Basic and Clinical Physiology and Pharmacology

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BackgroundSulfotransferases (SULTs) are phase II drug-metabolizing enzymes. SULTs also regulate the biological activities of biological signaling molecules, such as various hormones, bile acids, and monoamine neurotransmitters; therefore, they play critical roles in the endocrine and nervous systems. People are subject to various kinds of physical, chemical, toxicological, physiological, and psychological stresses at one time or another. The study of the effects produced by stress may lead to finding novel remedies for many disease conditions. The effect of repeated restraint stress on rat SULT expression has not been studied. MethodsThis study involves the effect of repeated restraint stress on SULT1A1 expressions. Male Sprague-Dawley rats (n=4) were subjected to repeated restraint stress 2 h/day for 7 days. Protein and RNA expression of SULT1A1 were analyzed by western blot and quantitative real time reverse transcription polymerase chain reaction, respectively, in important tissues. ResultsWe observed that repeated restraint stress increased the expression of SULT1A1 in the liver, adrenal glands, cerebellum, hypothalamus, and cerebral cortex in male rats. Patterns of enhanced expression were observed at both mRNA and protein level, indicating that repeated restraint stress stimulates enzyme expression at the transcriptional level. ConclusionsChanges of SULT1A1 expression in important tissues caused by repeated restraint stress will have a significant effect on drug metabolism and xenobiotics detoxification. The significant changes in endocrine glands and brain sections may also cause disturbances in hormone homeostasis, therefore leading to disease conditions. This report provides clues for the understanding of the effect of stresses on health.

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Exogenous dopamine induces dehydroepiandrosterone sulfotransferase (rSULT2A1) in rat liver and changes the pharmacokinetic profile of moxifloxacin in rats

Cited by 3 publications

References 38 publications

Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen

Dexamethasone suppresses the growth of human non-small cell lung cancer via inducing estrogen sulfotransferase and inactivating estrogen

Testosterone, DHEA and DHEA-S in patients with schizophrenia: A systematic review and meta-analysis

Repeated restraint stress upregulates rat sulfotransferase 1A1

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