Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate

Poreddy, Amruta R.; Neumann, William L.; Freskos, John N.; Rajagopalan, Raghavan; Asmelash, Bethel; Gaston, Kimberly R.; Fitch, Richard M.; Galen, Karen P.; Shieh, Jeng‐Jong; Dorshow, Richard B.

doi:10.1016/j.bmc.2012.03.015

Cited by 37 publications

(20 citation statements)

References 29 publications

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“…In the future, other methods, such as real time noninvasive point of care estimates of GFR employing fluorescent tracers may warrant further study in this population. 44 …”

Section: Other Estimates Of Gfrmentioning

confidence: 99%

GFR Estimating Equations and Liver Disease

Beben

Rifkin

2015

Advances in Chronic Kidney Disease

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It is important to accurately assess the glomerular filtration rate (GFR) of patients with liver disease in order to deliver care and allocate organs for transplantation in a way that improves outcomes. The most commonly used methods to estimate GFR in this population are based on creatinine, which is biased by these patients’ low creatinine production and potentially by elevated serum bilirubin and decreased albumin levels. None of the creatinine based estimated GFR (eGFR) equations have been specifically modified for a population with liver disease, and even measurement of a 24 hour creatinine clearance has limitations. In liver disease, all creatinine based estimates of GFR overestimate gold standard measured GFR (mGFR), and the degree of overestimation is highest at lower mGFR values and in more severe liver disease. Cystatin C based eGFR has shown promise in general population studies by demonstrating less bias than creatinine based eGFR and improved association with clinically important outcomes, but results in the liver disease population have been mixed and further studies are necessary. Ultimately, specific eGFR equations for liver disease or novel methods for estimating GFR may be necessary. However, for now, the limitations of currently available methods need to be appreciated to understand renal function in liver disease.

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“…In the future, other methods, such as real time noninvasive point of care estimates of GFR employing fluorescent tracers may warrant further study in this population. 44 …”

Section: Other Estimates Of Gfrmentioning

confidence: 99%

GFR Estimating Equations and Liver Disease

Beben

Rifkin

2015

Advances in Chronic Kidney Disease

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“…5 Dorshow et al reported that hydrophilic pyrazine-dicarboxylic acid derivatives can be excreted via the the kidneys, but the wavelength of pyrazine based fluorescent agents is still in the green region of the spectrum. 6 Additionally, in our previous studies, we developed a non-invasive approach to assess kidney function in real-time based on a miniaturized electronic device attached to the skin and a GFR agent: FITC-sinistrin, 7 which has better water solubility than FITC-inulin and there is no need to dialyze before injection. By these means, the elimination kinetics of the fluorescent agent FITC-sinistrin can be transcutaneously determined.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

et al. 2017

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“…On a brighter note, commercial attempts have been initiated to develop a rapid, sensitive, reproducible, affordable and user-friendly GFR technique [9,11]. Clearance of a freely filterable water-soluble molecule is being used with either noninvasive or minimally invasive approaches.…”

mentioning

confidence: 99%

Measuring glomerular filtration rate in the intensive care unit: no substitutes please

Molitoris

2013

Critical Care

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Acute kidney injury (AKI), due to its increasing incidence, associated morbidity and mortality, and potential for development of chronic kidney disease with acceleration to end-stage renal disease, has become of major interest to nephrologists and critical care physicians. The development of biomarkers to diagnose AKI, quantify risk and predict prognosis is receiving considerable attention. Yet techniques to accurately assess functional changes within patients still rely on the use of an insensitive marker (creatinine), creatinine-based estimating equations and unreliable urinary tests. Therefore, it is critical that functional tests be developed and used in combination with biomarkers, thus allowing improved care in AKI and chronic kidney disease patient populations.

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Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate

Cited by 37 publications

References 29 publications

GFR Estimating Equations and Liver Disease

GFR Estimating Equations and Liver Disease

Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

Measuring glomerular filtration rate in the intensive care unit: no substitutes please

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