2013
DOI: 10.1016/j.brainres.2012.10.046
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Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats

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Cited by 147 publications
(89 citation statements)
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“…Inhibition of neutrophil activation and infiltration into the ischemic brain was associated with an improving neurological outcome [15,28]. In this study, we found here that inhalation of 40 or 80 ppm H 2 S markedly inhibited the increased MPO activities induced by CA/CPR, and improved neurological results were observed.…”
Section: Discussionsupporting
confidence: 51%
See 1 more Smart Citation
“…Inhibition of neutrophil activation and infiltration into the ischemic brain was associated with an improving neurological outcome [15,28]. In this study, we found here that inhalation of 40 or 80 ppm H 2 S markedly inhibited the increased MPO activities induced by CA/CPR, and improved neurological results were observed.…”
Section: Discussionsupporting
confidence: 51%
“…H 2 S was also reported to induce neutrophil apoptosis and to suppress NSAID-induced granulocyte infiltration, as well as the expression of some leukocyte, endothelial adhesion molecules, and TNF-α [14,15]. Moreover, Yin and coauthors showed that, after global cerebral ischemia and reperfusion, exogenous H 2 S attenuated pro-inflammatory markers TNF-α and monocyte chemoattractant protein-1 in a dose-dependent manner [28]. Additionally, recent research by Xuan and colleague revealed that exogenous NaHS reduced the over-expression in IL-1β and TNF-α, as well as the extensive astrogliosis and microgliosis in the hippocampus of rat model of Alzheimer's disease [29].…”
Section: Discussionmentioning
confidence: 99%
“…47 Another study found that H2S, administered through NaHS, protects neurons in vitro from oxidative stress resulting from IR. 7 Additionally, in vivo models show that NaHS is able to reduce inflammation after cerebral IR, 48 and that the H2S donor diallyl sulfide, the primary organosulfur component of garlic, can reduce cerebral infarct volume and caspase-3 activation, a hallmark of apoptosis. 49 The gasotransmitter also shows cytoprotective effects in the liver; Na2S was administered to mice in a hepatic IR injury model and mitigated elevations of serum alanine aminotransferase and aspartate aminotransferase levels.…”
Section: H2s Protection Of Organ Systemsmentioning
confidence: 99%
“…Bcl-2 is an anti-apoptotic protein that affects the mitochondrial outer membrane. Bcl-2 prevents cytochrome C from releasing into the cytoplasm, which is a vital step in the apoptotic process (24,25). Targeted disruption of the Bcl-2 gene in mice exacerbates focal cerebral ischemic injury (26).…”
Section: Discussionmentioning
confidence: 99%