Exogenous hydrogen sulfide restores CSE and CBS but no 3-MST protein expression in the hypothalamus and brainstem after severe traumatic brain injury

Cruz, Saúl Huerta de la; Rodríguez‐Palma, Erick J.; Santiago-Castañeda, Cindy; Beltrán-Ornelas, Jesús H.; Sánchez-López, Araceli; Rocha, Luisa; Centurión, David

doi:10.1007/s11011-022-01033-1

Cited by 16 publications

(6 citation statements)

References 52 publications

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“…Subsequently, we used NaHS, IGF-1, and MR-409 to promote the expression of H 2 S, IGF-1, and GH in vitro and in vivo to explore their effects in TBI. Previous studies have found that exogenous H 2 S through NaHS treatment restores mitochondrial function after TBI (23,24,31,32). Similarly, we demonstrated that additional NaHS administration restored the cell viability of HT22 cells and the mitochondrial function after TBI.…”

Section: Discussionsupporting

confidence: 82%

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Dynamic Changes and Effects of H2S, IGF-1, and GH in the Traumatic Brain Injury

Zhang,

Wu,

Kong

et al. 2024

Biochem Genet

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Background: The goal of this investigation was to examine the expression changes of H 2 S, IGF-1, and GH after TBI and to detect their roles after TBI.Methods: In this study, we rst collected cerebrospinal uid (CSF) and plasma from TBI patients at different times after injury and evaluated the concentrations of H 2 S, IGF-1, and GH. In vitro TBI conditions were stimulated by using HT22 hippocampal neurons and LPS-induced BV2 microglia cells. Models of TBI were established using controlled cortical impact (CCI) in vivo. CCK-8 assay, qRT-PCR and ELISA were used. Western blot was performed to assess the expression of CBS, CSE, IGF-1, and GHRH. Moreover, the recovery of TBI mice was evaluated for behavioral function by applying the modi ed Neurological Severity Score (mNSS), the Rotarod test, and the Morris water maze.Results: We discovered that serum H 2 S, CSF H 2 S, and serum IGF-1 concentrations were all adversely associated with the severity of the TBI, while the concentrations of IGF-1 and GH in CSF and GH in the serum were all positively related to TBI severity. Experiments in vitro and in vivo indicated that activated-BV2 cells enhanced the production of in ammatory cytokines and suppressed the cell viability of HT22 cells. In addition, treatment with NaHS, IGF-1, and GH alleviated the activation of BV2 cells. Furthermore, NaHS, IGF-1, and GH treatment alleviated motor function de cits after TBI. Conclusion:This study gives novel information on the functions of H 2 S, IGF-1, and GH in TBI.

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Section: Discussionsupporting

confidence: 82%

“…Exogenous administration of H 2 S prevents vascular dysfunction and the development of hemodynamic impairments after TBI (23,24). These evidences suggested that H 2 S administration had a protective effect against TBI.…”

Section: Introductionmentioning

confidence: 83%

Dynamic Changes and Effects of H2S, IGF-1, and GH in the Traumatic Brain Injury

Zhang,

Wu,

Kong

et al. 2024

Biochem Genet

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“…The research shows that daily injections of NaHS, an H 2 S donor, increase the production of CBS and CSE in a way that varies over time and by tissue. Nevertheless, these injections had no impact on 3-MST, suggesting that H 2 S production may be involved in abnormalities of the hypothalamus and brainstem after a traumatic brain injury [ 153 ].…”

Section: Role Of Hydrogen Sulfidementioning

confidence: 99%

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

Andrés,

Pérez de la Lastra,

Bustamante Munguira

et al. 2024

IJMS

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The phrase “Let food be thy medicine…” means that food can be a form of medicine and medicine can be a form of food; in other words, that the diet we eat can have a significant impact on our health and well-being. Today, this phrase is gaining prominence as more and more scientific evidence suggests that one’s diet can help prevent and treat disease. A diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of heart disease, cancer, diabetes, and other health problems and, on the other hand, a diet rich in processed foods, added sugars, and saturated fats can increase the risk of the same diseases. Electrophilic compounds in the diet can have a significant impact on our health, and they are molecules that covalently modify cysteine residues present in the thiol-rich Keap1 protein. These compounds bind to Keap1 and activate NRF2, which promotes its translocation to the nucleus and its binding to DNA in the ARE region, triggering the antioxidant response and protecting against oxidative stress. These compounds include polyphenols and flavonoids that are nucleophilic but are converted to electrophilic quinones by metabolic enzymes such as polyphenol oxidases (PPOs) and sulfur compounds present in foods such as the Brassica genus (broccoli, cauliflower, cabbage, Brussel sprouts, etc.) and garlic. This review summarizes our current knowledge on this subject.

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“…Furthermore, 3-MST decreased only in the hypothalamus. At the same time, regular intra-abdominal administration of NaHS restored the levels of CBS and CSE, and of 3-MST [ 127 ].…”

Section: Endogenous and Exogenous H 2 S In Neurotr...mentioning

confidence: 99%

The Role of Hydrogen Sulfide in Regulation of Cell Death following Neurotrauma and Related Neurodegenerative and Psychiatric Diseases

Rodkin

Nwosu

Sannikov

et al. 2023

IJMS

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Injuries of the central (CNS) and peripheral nervous system (PNS) are a serious problem of the modern healthcare system. The situation is complicated by the lack of clinically effective neuroprotective drugs that can protect damaged neurons and glial cells from death. In addition, people who have undergone neurotrauma often develop mental disorders and neurodegenerative diseases that worsen the quality of life up to severe disability and death. Hydrogen sulfide (H2S) is a gaseous signaling molecule that performs various cellular functions in normal and pathological conditions. However, the role of H2S in neurotrauma and mental disorders remains unexplored and sometimes controversial. In this large-scale review study, we examined the various biological effects of H2S associated with survival and cell death in trauma to the brain, spinal cord, and PNS, and the signaling mechanisms underlying the pathogenesis of mental illnesses, such as cognitive impairment, encephalopathy, depression and anxiety disorders, epilepsy and chronic pain. We also studied the role of H2S in the pathogenesis of neurodegenerative diseases: Alzheimer’s disease (AD) and Parkinson’s disease (PD). In addition, we reviewed the current state of the art study of H2S donors as neuroprotectors and the possibility of their therapeutic uses in medicine. Our study showed that H2S has great neuroprotective potential. H2S reduces oxidative stress, lipid peroxidation, and neuroinflammation; inhibits processes associated with apoptosis, autophagy, ferroptosis and pyroptosis; prevents the destruction of the blood-brain barrier; increases the expression of neurotrophic factors; and models the activity of Ca2+ channels in neurotrauma. In addition, H2S activates neuroprotective signaling pathways in psychiatric and neurodegenerative diseases. However, high levels of H2S can cause cytotoxic effects. Thus, the development of H2S-associated neuroprotectors seems to be especially relevant. However, so far, all H2S modulators are at the stage of preclinical trials. Nevertheless, many of them show a high neuroprotective effect in various animal models of neurotrauma and related disorders. Despite the fact that our review is very extensive and detailed, it is well structured right down to the conclusions, which will allow researchers to quickly find the proper information they are interested in.

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Exogenous hydrogen sulfide restores CSE and CBS but no 3-MST protein expression in the hypothalamus and brainstem after severe traumatic brain injury

Cited by 16 publications

References 52 publications

Dynamic Changes and Effects of H2S, IGF-1, and GH in the Traumatic Brain Injury

Dynamic Changes and Effects of H2S, IGF-1, and GH in the Traumatic Brain Injury

Electrophilic Compounds in the Human Diet and Their Role in the Induction of the Transcription Factor NRF2

The Role of Hydrogen Sulfide in Regulation of Cell Death following Neurotrauma and Related Neurodegenerative and Psychiatric Diseases

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