2017
DOI: 10.3389/fimmu.2017.00207
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Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens

Abstract: The emergence of multidrug-resistant bacteria presents a severe threat to public health and causes extensive losses in livestock husbandry and aquaculture. Effective strategies to control such infections are in high demand. Enhancing host immunity is an ideal strategy with fewer side effects than antibiotics. To explore metabolite candidates, we applied a metabolomics approach to investigate the metabolic profiles of mice after Klebsiella pneumoniae infection. Compared with the mice that died from K. pneumonia… Show more

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Cited by 82 publications
(87 citation statements)
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“…Statistical analysis was carried out as described previously (Zeng et al ., ; Chen et al ., ). Initial peak detection and mass spectral deconvolution were performed using Agilent software (Agilent 6.0).…”
Section: Methodsmentioning
confidence: 97%
“…Statistical analysis was carried out as described previously (Zeng et al ., ; Chen et al ., ). Initial peak detection and mass spectral deconvolution were performed using Agilent software (Agilent 6.0).…”
Section: Methodsmentioning
confidence: 97%
“…Strategies managing antibiotic‐resistant bacteria include antibiotic‐independent and ‐dependent methods. The antibiotic‐independent method includes vaccines, metabolome‐reprogramming molecules, phage therapy and antibacterial peptides (Peng et al ., ; Chen et al ., ; Du et al ., ; Pires et al ., ; Wang et al ., ; Zeng et al ., ; Zhang et al ., ; Jiang et al ., ). Vaccines stimulate the host's active immunity against bacterial pathogens (Guo et al ., ; Cheng et al ., ; Peng et al ., ).…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, NO acts as a signaling messenger that promotes the growth and activity of immune cell types, including macrophages and neutrophils (24, 29). Inhibition of inducible NOS (iNOS) or total NOS in macrophages or peripheral blood neutrophils significantly blocks phagocytosis, intracellular killing, and increases the survival of S. aureus (23, 3032). These observations result in the development of NO delivery systems that can harness the antimicrobial properties of this short-lived, evanescent gas (24, 33).…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, studies focusing on the cross-talking between metabolic regulation and immune system reveal an active role of metabolic regulation in controlling the pathogenic bacteria. In several bacterial infection models, the host that survive the infection display distinctive metabolic pathways (1823). Numerous metabolites identified from these metabolic pathways related to the survivors can be immunoregulators that modulate the function of the immune system via various mechanisms, including the activation of PI3K/Akt1, elevated expression of cytokines, and promotion of NO production (1823).…”
mentioning
confidence: 99%
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