Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients

Tokutake, Takayoshi; Baba, Hisami; Shimada, Yuji; Takeda, Wataru; Sato, Keijiro; Hiroshima, Yukihiko; Kirihara, Takehiko; Shimizu, Ikuo; Nakazawa, Hayakazu; Kobayashi, Hikaru; Ishida, Fumihiro

doi:10.1371/journal.pone.0157835

Cited by 24 publications

(20 citation statements)

References 11 publications

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“…Mg 2+ can potentiate the activation of factor X by activated factor IX while in the presence of activated factor VIII, phospholipids and Ca 2+ [88], the activation of factor IX by activated factor VII-tissue factor complex [88], and the inactivation of activated factor V by activated protein C [89]. Mg 2+ also affects clot time by accelerating clotting at low concentrations and slowing or completely preventing fibrin clotting at high concentration (as it competes with Ca 2+ for binding to coagulation factors [90][91][92][93]). Furthermore, Mg 2+ shortens fibrin clot lysis time, possibly through an inhibition of PAI-1 in the presence of thrombin and vitronectin [92].…”

Section: Changes In Metal Ion Homeostasismentioning

confidence: 99%

Coagulatory Defects in Type-1 and Type-2 Diabetes

Sobczak

Stewart

2019

IJMS

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Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

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Section: Changes In Metal Ion Homeostasismentioning

confidence: 99%

Coagulatory Defects in Type-1 and Type-2 Diabetes

Sobczak

Stewart

2019

IJMS

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“…In humans and animals extracellular Mg has cardioprotective properties because it attenuates all the agonist-induced vasoconstriction molecules, including endothelin-1 (EN-1), helping preserve vascular tone and preventing coronary vasospasm [1–5]. These cardioprotective effects are reinforced by the fact that Mg assists the coagulation reactions, binding specific coagulation proteins in case of endothelial damage [6]. …”

Section: Introductionmentioning

confidence: 99%

A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

et al. 2017

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BackgroundMagnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Consequently Mg and Ca imbalance is associated with a high risk of endothelial dysfunction, the main process observed during acute aortic dissection (AAD); in this clinical condition, which mainly affects elderly men, smooth muscle cell alterations lead to intimal tears, creating a false new lumen in the media of the aorta. AAD patients have a high risk of mortality as a result of late diagnosis because often it is not distinguished from other cardiovascular diseases.We investigated Mg and Ca total circulating levels and the associated pro-inflammatory mediators in elderly AAD patients, to gain further information on the pathophysiology of this disorder, with a view to suggesting newer and earlier potential biomarkers of AAD.ResultsTotal circulating Mg and Ca levels were both lower in AAD patients than controls (p < 0.0001). Using Ca as cut-off, 90% of AAD patients with low Ca (<8.4 mg/dL) came into the type A classification of AAD. Stratifying AAD according to this cut-off, Mg was lower in patients with lower total Ca.Compared to controls, both type A and B AAD patients had higher levels of all the pro-coagulant and pro-inflammatory mediators analyzed, including sP-sel, D-dimer, TNF-α, IL-6, and CRP (p < 0.05). Dividing types A and B using the Stanford classification, no significant differences were found (p > 0.05) The levels of both ICAM-1 and EN-1 were lower in AAD than in a control group (p < 0.0001 and p < 0.05 respectively).ConclusionsThese findings suggest that low Mg and Ca in AAD elderly patients may contribute to altering normal endothelial physiology and also concur in changing the normal concentrations of different mediators involved in vasodilatation and constriction, associated with AAD onset and severity.

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“…Such as endothelin-1, this effect has been associated with suppressor effect against many factors showing agonistic effect in the development of vasoconstriction (17)(18)(19). In the case of endothelial damage, it also blocks abnormal coagulation by binding specific coagulation factors such as Ca (20). The control of abnormal coagulation is important in terms of many factors such as the viscosity of the blood, the maintenance of adequate blood flow to the tissues, and the inhibition of the development of atherosclerotic plaques.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Serum Magnesium Levels in Patients with Erectile Dysfunction and Healthy Peers

Benli̇¹,

Çırakoğlu²,

Ayyıldız³

2018

JAREM

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Objective: Erectile dysfunction (ED) is a very common health problem among men that disrupts the quality of life. The aim of this study was to investigate whether serum magnesium levels in patients with ED are different from those in healthy individuals. Methods:The study accessed the data of 344 patients who applied to the urology clinic from 2014 to 2016. Patients were divided into two groups: patients with ED, Group 1 (n=155) and those without ED, Group 2 (control; n=189). Characteristics such as patients' age, additional diseases, and smoking habits were recorded and compared between the two groups along with laboratory parameters such as levels of serum magnesium, calcium, and inflammatory markers. Sexual situation was assessed with the SHIM-5 form.Results: Patients aged 63.15±8.90 years were included in Group 1 and those aged 61.63±8.01 years were included in Group 2 (p=0.101). There were no differences between the groups in terms of BMI and waist circumference (p>0.05). Serum magnesium levels were 1.94±0.20 and 2.00±0.17 mg/dl in groups 1 and 2, respectively (p=0.008). WBC value for inflammatory makers were 6.94±1.74 and 6.58±1.43 in groups 1 and 2, respectively (p=0.04).Conclusion: Our study found that serum magnesium values were reduced in ED patients than in the control group. Therefore, it may be beneficial to determine serum magnesium values in ED patients. Additionally, serum magnesium values may be used as markers for the early identification of patients at risk.

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Exogenous Magnesium Chloride Reduces the Activated Partial Thromboplastin Times of Lupus Anticoagulant-Positive Patients

Cited by 24 publications

References 11 publications

Coagulatory Defects in Type-1 and Type-2 Diabetes

Coagulatory Defects in Type-1 and Type-2 Diabetes

A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

Comparison of Serum Magnesium Levels in Patients with Erectile Dysfunction and Healthy Peers

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