Exogenous Otx2 protects midbrain dopaminergic neurons from MPP+ by interacting with ATP5a1 and promoting ATP synthesis

Xue, Jinhua; Li, Yanning; Qi, Yue; Zhang, Ziwei; Tang, Xiangming

doi:10.1016/j.neuro.2022.05.013

Cited by 1 publication

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further analysis showed that MSTRG.56713.8 , MSTRG.51570.1 , and MSTRG.32990.14 were significantly down‐regulated in MII oocytes compared with the GV stage, with ATP5A1 , ATP5B and ATP5EP2 as cy‐target genes, respectively. Reports have showed that the ATP5A1 , ATP5B , and ATP5EP2 , which encode components of mitochondrial ATP synthetase (Wang, Chang, et al, 2021; Xue et al, 2022), can catalyse ATP synthesis, fatty acid β‐oxidation, lipid metabolism. ACADVL , being the target gene of MSTRG.10070.2 , can encode ultra‐long chain‐specific acyl CoA dehydrogenase, and catalyse the first step of mitochondrial fatty acid β‐oxidation (Chen et al, 2020; Li, Zhang, et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Further analysis showed that .56713.8, MSTRG.51570.1, and MSTRG.32990.14 were significantly down-regulated in MII oocytes compared with the GV stage, with ATP5A1, ATP5B and ATP5EP2 as cy-target genes, respectively. Reports have showed that the ATP5A1, ATP5B, and ATP5EP2, which encode components of mitochondrial ATP synthetase (Wang, Chang, et al, 2021;Xue et al, 2022) CoA and plays a crucial role in fatty acid oxidation and lipid metabolism (Li et al, 2019;. According to cis-target genes in lncRNA transcripts, lncRNAs may directly or indirectly regulate the expression of target genes to affect signalling pathways related to energy metabolism in equine oocyte maturation.…”

Section: Smartmentioning

confidence: 99%

See 1 more Smart Citation

Transcriptome analyses reveal transcriptional profiles of horse oocytes before and after in vitro maturation

Song,

Jiang,

et al. 2023

Reprod Domestic Animals

View full text Add to dashboard Cite

Oocyte in vitro maturation is necessary for the study and application of animal‐assisted reproduction technology in animal reproduction and breeding. The comprehensive transcriptional profile of equine oocyte maturated in vitro has not been fully mined yet, which makes many key transcriptional events still unidentified. Here, Smart‐seq2 was performed to analyse the gene expression pattern and the underlying regulatory mechanism of horse germinal vesicle (GV) and in vitro metaphase II (MII) oocytes. The results showed that 6402 genes (2640 up‐regulated and 3762 down‐regulated in MII samples compared to GV) and 4021 lncRNA transcripts (1210 up‐regulated and 2811 down‐regulated in MII samples compared to GV) were differentially expressed in GV and MII oocytes. Further, GO and KEGG analysis found that differentially expressed mRNAs and lncRNAs were mainly enriched in the pathways related to energy and lipid metabolism. In addition, LGALS3 was found a key gene in mediating the regulation of oocyte meiosis recovery and fertilization ability. This study provides novel knowledge about gene expression and energy metabolism during equine oocyte maturation and a reference for the further study and application of assisted reproductive technology in horse reproduction and breeding.

show abstract