Exogenous pituitary and recombinant growth hormones induce insulin and insulin-like growth factor 1 resistance in pig adipose tissue

Walton, P. E.; Etherton, Terry D.; Chung, C. S.

doi:10.1016/0739-7240(87)90014-2

Cited by 66 publications

(23 citation statements)

References 12 publications

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“…Insulin is an anabolic hormone promoting glucose uptake by tissues. Strong evidences suggested that circulating insulin level could be elevated by GHRH and GH treatment in pigs (Walton et al, 1987;Gopinath and Etherton, 1989;Kirkwood et al, 1989;Dubreuil et al, 1991;Johnson et al, 1990;Klindt et al, 1995). In the current study, the improvement in serum insulin concentration may be ascribed to the higher level of GH in pigs fed betaine.…”

Section: Discussioncontrasting

confidence: 41%

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Huang

Han

et al. 2006

Livestock Science

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Section: Discussioncontrasting

confidence: 41%

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Huang

Han

et al. 2006

Livestock Science

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“…This latter phenomenon is well documented in man, where human GH causes insulin resistance at two levels, at the hepatic level where it impairs the ability ofinsulin to suppress glucose production (Hansen, Tsalikian, Beaufrere et al 1986) and at the extrahepatic level where it impairs the insulin-mediated glucose utilization by peripheral tissues (Rizza, Mandarino & Gerich, 1982;Rosenfeld, Wilson, Dollar et al 1982). The extrahepatic down-regulation or desensitization has also been observed in pigs given porcine GH (Walton, Etherton & Chung, 1987), where insulin is thought to regulate the utilization of glucose for lipogenesis.…”

Section: Discussionmentioning

confidence: 87%

Influence of protein nutrition on the response of growing lambs to exogenous bovine growth hormone

MacRae¹,

Bruce²,

Hovell³

et al. 1991

Journal of Endocrinology

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Interactions between protein supply and the anabolic response to exogenous bovine (b) GH have been examined in two experiments using 28-35 kg lambs sustained entirely by intragastric infusion of volatile fatty acids (700 kJ/kg W 0.75 per day) into the rumen and the casein (600 mg (low protein; LP) or 1200 mg (high protein; HP)/kg W 0.75 per day) into the abomasum. Sheep received continuous i.v. infusions of bGH for 6 days in experiment 1 and for 18 days in experiment 2. Nitrogen balances were determined daily throughout both experiments and blood samples, from indwelling catheters, were assayed for GH, insulin-like growth factor-I (IGF-I), insulin and glucose. Infusion of bGH increased plasma GH concentration by five- to sixfold in all animals. There was an increase in N retention in both HP and LP animals over the first 2-3 days of GH administration. HP animals sustained higher N retentions (31%; P less than 0.05) throughout the GH administration but LP animals did not. In contrast, plasma IGF-I concentrations increased progressively over the first 72 to 96 h of GH administration in all sheep and thereafter remained significantly (P less than 0.05) elevated until termination of the GH infusion. In lambs which received both HP and LP infusion in experiment 1 the increase in IGF-I and LP infusions in experiment 1 the increase in IGF-I concentration by day 6 of GH administration was significantly (P less than 0.05) greater when they received the higher protein intake.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…GH antagonizes insulin-stimulated lipid filling in mature pig adipocytes in vivo (27) and in vitro (28). However, GH does not overcome Dex-enhanced adipogenesis (32).…”

Section: Obesity Researchmentioning

confidence: 99%

Hormonal Regulation of Leptin mRNA Expression and Preadipocyte Recruitment and Differentiation in Porcine Primary Cultures of S‐V Cells

et al. 1998

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CHEN, X.L., D.B. HAUSMAN, R.G. DEAN, G.J. HAUSMAN. Hormonal regulation of leptin mRNA expression and preadipocyte recruitment and differentiation in porcine primary cultures of S-V cells. Obes Res. 1998;6:164-172. The hormonal regulation of leptin mRNA expression and the association between leptin expression and adipocyte differentiation were examined in primary cultures of porcine S-V cells with Northern blot and immunocytochemical analysis. Seeding for 3 days with fetal bovine serum (FBS) with varying levels of dexamethasone (Dex) increased levels of leptin mRNA in a dosedependent manner in parallel with increases in the proportion of preadipocytes (AD-3 positive cells; AD-3, a preadipocyte marker). Six-day treatment with 10 or 850 nM insulin after FBS+Dex treatment resulted in a similar increase in leptin mRNA expression and morphological differentiation. However, significantly lower levels of leptin mRNA and smaller fat cells were observed in cultures treated with l nM insulin or 10 nM insulin-like growth factor-I (IGF-I). Dex-induced increases in leptin mRNA levels and AD-3 cell numbers were blocked completely by the addition of transforming growth factor+ (TGF-P) to FBS+Dex-treated cultures. However TGF-f3 significantly increased fat cell size and leptin mRNA expression when added to ITS (insulin, 850 nM; transferrin, 5 pg/ml; and selenium, 5 pg/mL) treated cultures during the lipid-filling stage. When added with ~~

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Exogenous pituitary and recombinant growth hormones induce insulin and insulin-like growth factor 1 resistance in pig adipose tissue

Cited by 66 publications

References 12 publications

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine

Influence of protein nutrition on the response of growing lambs to exogenous bovine growth hormone

Hormonal Regulation of Leptin mRNA Expression and Preadipocyte Recruitment and Differentiation in Porcine Primary Cultures of S‐V Cells

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