Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans

Abstract

These data demonstrate that LF is able to influence cutaneous immune and inflammatory responses, possibly because of an impaired production of local proinflammatory cytokines.

The Cutaneous Biochemical Redox Barrier: A Component of the Innate Immune Defenses against Sensitization by Highly Reactive Environmental Xenobiotics

“…4; p ϭ 0.0005, n ϭ 8 subjects). The mean percentage reduction in LCs following DNCB was 18% (SE Ϯ 3.3), which is similar to that seen previously in normal volunteers following topical application of the potent chemical contact allergen diphencyprone (14) or the intradermal administration of cytokines such as TNF-␣ (15).…”

Lactoferrin as an Adjunctive Agent in the Treatment of Bacterial Infections Associated with Diabetic Foot Ulcers

“…This cytokine also promotes the migration of immature Langerhans cells to human lymph nodes involved in chronic skin inflammation (Geissmann et al, 2002). In this regard, the antiinflammatory property of lactoferrin applied topically to humans and mice has been linked to a decrease in the migration of skin Langerhans cells induced by DPC or oxazolone (Griffiths et al, 2001;Kimber et al, 2002;Cumberbatch et al, 2000). As in the case of DPC or oxazonolone, homolog lactoferrin inhibits the mobilization of Langerhans cells induced by intradermic IL 1beta in humans (Cumberbatch et al, 2003) and mice (Cumberbatch et al, 2000).…”

“…T r i a l s w i t h h u m a n v o l u n t e e r s a n d a s s a y s o n m i c e h a v e a d d r e s s e d d o w n -r e g u l a t o r y properties of bovine or human lactoferrin on pro-inflammatory cytokines generated during dermal allergic responses induced by diphenylcyclopropenone (DPC) (Griffiths et al, 2001;Kimber et al, 2002) and oxazolone (Cumberbatch et al, 2000).…”

Healthy Multifunctional Spectra of Milk Glycoproteins and Their Fragments – a Review Article

“…Another potential anti-infl ammatory role of LF is through the sequestration of "free" iron at infl ammatory foci, such as rheumatoid joints, thus preventing catalysis of the production of damaging free radicals [Trif et al, 2001 andGuillen et al, 2000]. LF can also reduce cutaneous infl ammation by inhibiting migration of Langerhans cells [Griffi ths et al, 2001]. These anti-infl ammatory effects of LF are probably initiated following release of LF from neutrophils, and could thus be viewed as a further manifestation of the role of neutrophils in infl ammation.…”