An approximately 7‐week‐old female American Bulldog was presented for head injury and seizures. The dog was obtunded with absent left‐sided postural reactions, absent left palpebral reflex, delayed vestibulo‐ocular reflex bilaterally, and calvarial hyperesthesia. CT revealed a fragmented, depressed fracture of the right frontal bone, with an associated abscess and evidence of raised intracranial pressure. The dog initially declined on medical management. Following a CT‐guided drainage procedure, the dog improved and remained clinically well twenty months later. This is the first report of minimally‐invasive sequential CT allowing successful drainage and culture of a canine intracerebral abscess.