Exophytic Parietal Skin Metastases of Renal Cell Carcinoma

Abstract

The common sites for metastasis of renal cell carcinoma are lung, kidney, adrenal glands, liver, and contralateral kidney. We report an unusual case of cutaneous metastasis of renal cell carcinoma in a 68-year-old woman who was treated for renal cell carcinoma with partial right nephrectomy and multikinase angiogenesis inhibitor (sunitinib) 10 years ago.

Cutaneous Metastatic Renal Cell Carcinoma

“…2 There are limited reports on latent cutaneous metastatic RCC. [4][5][6][7][8][9][10] We also present an unusual case of late recurrence of RCC 15 years after initial total nephrectomy presenting as cutaneous metastasis. Depending on the number and site of metastatic lesions, various treatment approaches including chemotherapy, radiotherapy or surgery can be selected.…”

“…Distant metastases occur in about one-third of patients with RCC. 4 Although the lungs, liver, bones, adrenal glands, or contralateral kidneys are the most common sites for RCC metastases, distant metastases to the skin mainly on the head and face accounts for 3% to 6% of the metastatic RCCs, usually indicating a widespread disease. 2,5 Cutaneous metastatic lesions are commonly characterized by a large pulsatile single nodule frequently with a vascular nature and rapid development.…”

“…2,5 Cutaneous metastatic lesions are commonly characterized by a large pulsatile single nodule frequently with a vascular nature and rapid development. 4 The lesions usually present 6 months to 5 years following the initial diagnosis of RCC. 5 Recurrences that occur 10 years or more after the initial nephrectomy are considered late ones.…”

Facial Cutaneous Metastasis in Renal Cell Carcinoma

“…Surgical removal of the skin lesion is recommended not only for cosmesis, but also when there are concerning tumor features such as rapid growth, local extension, and bleeding. Selected cases of cutaneous metastasis of RCC have been considered to undergo radiotherapy [ 18 ]. Adjuvant therapy for solitary cutaneous metastases of RCC has not been described so far.…”

“…Patients with metastatic RCC involving atypical sites, such as a digit and the tongue, have shown variable responses to adjuvant chemotherapy [ 9 , 10 ]. In such cases, a palliative approach has been considered [ 18 ].…”