Exopolysaccharide-peptide complex from oyster mushroom (Pleurotus ostreatus) protects against hepatotoxicity in rats

A Titanium (IV)–Dithiophenolate Complex and Its Chitosan Nanocomposite: Their Roles towards Rat Liver Injuries In Vivo and against Human Liver Cancer Cell Lines

“…Further, GSH depletion led to the inhibition of GPx and GST. Additionally, SOD inhibition resulted from the oxidation of the cysteine residues in its molecules [ 3 , 23 ].…”

“…The liver has numerous functions including the synthesis of proteins, glucose, bile, and clotting factors and the breaking down of hormones, certain drugs, and xenobiotics [ 1 , 2 ]. Hepatic metabolism of some drugs and toxins such as carbon tetrachloride (CCl 4 ) augments the generation of free radicals and reactive oxygen species (ROS), resulting in oxidative stress (OS), hepatoxicity, and deterioration of macromolecules as proteins, lipids, carbohydrates, and nucleic acids [ 3 , 4 ]. The hepatotoxicity induced by xenobiotics is dependent on their dosage, nature, and period of exposure [ 1 , 2 ].…”

Curative Role of Dithiophenolato Titanium (IV)-Chitosan Nanocomposite Complex Against Carbon Tetrachloride-Induced Liver Injuries

“…Also the inhibition of GPx and GST activities probably due to GSH depletion. SOD inhibition may be concerned with the oxidation of cysteine residues in the enzyme molecules by superoxide radicals and H 2 O 2 [3,29].…”

“…The liver has numerous functions including the synthesis of proteins, glucose, bile, and clotting factors, besides breaking down hormones, certain drugs, and xenobiotics [1,2]. Hepatic metabolism of medicinal agents and toxins as carbon tetrachloride (CCl 4 ) involves disturbed hepatic cell biochemistry with the augmented generation of free radicals and reactive oxygen species (ROS) and redox imbalance with secondary deterioration to proteins, lipids, carbohydrates, and nucleic acids [3,4]. The xenobiotic-induced hepatotoxicity ranging from a subclinical anicteric state to severe necroin ammatory hepatitis (acute, recurrent, or chronic) and cirrhosis, relies on the dosage, nature, and period of exposure to the xenobiotics, the antioxidant defense, and attendant exposure to another disease or xenobiotics [1,2].…”

Investigation into the Intake of Edible Mushroom <i>Pleurotus ostreatus</i> (Aqueous Extract Oyster Mushroom) on Biochemical Indices of Female Wistar Rats

“…Provide important nutrients (selenium, potassium, riboflavin, niacin, vitamin D, protein and fiber) and bioactive compounds (lectins, proteases, fibrinolytic enzymes, protease inhibitors, and phenolic compounds) [1]- [9]. Studies report that their bioactive compounds are responsible by effects anti-inflammatory [10], antinociceptive [11], antioxidant [12] [13] [14] [15], antitumour [16] [17] [18], enhancer of iron bioavailability [19], gastroprotective [20], hepatoprotective [21] [22] [23], hypocholesterolemic [12] [24] [25] [26], hipoglycemic [2] [25] [27]- [39], immunomodulador [4] and nephroprotective [40] [41] (Figure 1).…”