Exosomal circRNA: emerging insights into cancer progression and clinical application potential

Zhang, Fan; Jiang, Jiajia; Yan, Yongmin; Xu, Wenrong

doi:10.1186/s13045-023-01452-2

Cited by 62 publications

(21 citation statements)

References 190 publications

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“…One of the important functions of cirRNAs is to bind with RNA or proteins to regulate alternative splicing and transcription ( Wang H. et al, 2019 ; Xu Y. et al, 2020 ). Dysregulated circRNAs and their contribution to influencing various malignancies have been well researched, with potential for clinical applications ( Li et al, 2015 ; Zhang et al, 2023 ). Exosome-encapsulated circRNAs are found to be more stable in the serum/plasma of patients and, hence, more likely to indicate accurate lncRNA-associated clinical insights than other free circRNA species ( Li et al, 2015 ).…”

Section: Exosomes and Exosome-derived Biomoleculesmentioning

confidence: 99%

Prospects of liquid biopsy in the prognosis and clinical management of gastrointestinal cancers

Mondal,

Shinde,

Sinha

et al. 2024

Front. Mol. Biosci.

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Gastrointestinal (GI) cancers account for one-fourth of the global cancer incidence and are incriminated to cause one-third of cancer-related deaths. GI cancer includes esophageal, gastric, liver, pancreatic, and colorectal cancers, mostly diagnosed at advanced stages due to a lack of accurate markers for early stages. The invasiveness of diagnostic methods like colonoscopy for solid biopsy reduces patient compliance as it cannot be frequently used to screen patients. Therefore, minimally invasive approaches like liquid biopsy may be explored for screening and early identification of gastrointestinal cancers. Liquid biopsy involves the qualitative and quantitative determination of certain cancer-specific biomarkers in body fluids such as blood, serum, saliva, and urine to predict disease progression, therapeutic tolerance, toxicities, and recurrence by evaluating minimal residual disease and its correlation with other clinical features. In this review, we deliberate upon various tumor-specific cellular and molecular entities such as circulating tumor cells (CTCs), tumor-educated platelets (TEPs), circulating tumor DNA (ctDNA), cell-free DNA (cfDNA), exosomes, and exosome-derived biomolecules and cite recent advances pertaining to their use in predicting disease progression, therapy response, or risk of relapse. We also discuss the technical challenges associated with translating liquid biopsy into clinical settings for various clinical applications in gastrointestinal cancers.

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Section: Exosomes and Exosome-derived Biomoleculesmentioning

confidence: 99%

Prospects of liquid biopsy in the prognosis and clinical management of gastrointestinal cancers

Mondal,

Shinde,

Sinha

et al. 2024

Front. Mol. Biosci.

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“…Exosomes can promote tumor growth and metastasis by modulating the microenvironment and promoting angiogenesis, invasion, and immune evasion 45 . Exosomes secreted by cancer cells can also transfer oncogenic factors, such as miRNAs and proteins, to adjacent or distant cells, thereby promoting or inhibiting cancer development and resistance to therapy 46 In the early stages of cancer, cancer cell‐derived exosomes can induce apoptosis of neighboring cells, thereby promoting tumor development. However, in the later stages of cancer, cancer cell‐derived exosomes can inhibit the apoptosis of cancer cells, thereby promoting tumor survival and resistance to therapy 47…”

Section: Exosomes In Different Types Of Pcdmentioning

confidence: 99%

The role of exosomes in cancer‐related programmed cell death

Li,

Jing,

et al. 2023

Immunological Reviews

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SummaryCancer arises from the growth and division of uncontrolled erroneous cells. Programmed cell death (PCD), or regulated cell death (RCD), includes natural processes that eliminate damaged or abnormal cells. Dysregulation of PCD is a hallmark of cancer, as cancer cells often evade cell death and continue to proliferate. Exosomes nanoscale extracellular vesicles secreted by different types of cells carrying a variety of molecules, including nucleic acids, proteins, and lipids, to have indispensable role in the communication between cells, and can influence various cellular processes, including PCD. Exosomes have been shown to modulate PCD in cancer cells by transferring pro‐ or antideath molecules to neighboring cells. Additionally, exosomes can facilitate the spread of PCD to surrounding cancer cells, making them promising in the treatment of various cancers. The exosomes' diagnostic potential in cancer is also an active area of research. Exosomes can be isolated from a wide range of bodily fluids and tissues, such as blood and urine, and can provide a noninvasive way to monitor cancer progression and treatment response. Furthermore, exosomes have also been employed as a delivery system for therapeutic agents. By engineering exosomes to carry drugs or other therapeutic molecules, they can be targeted specifically to cancer cells, reducing toxicity to healthy tissues. Here, we discussed exosomes in the diagnosis and prevention of cancers, tumor immunotherapy, and drug delivery, as well as in different types of PCD.

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“…Exosomal circRNAs have a significant role in gastrointestinal cancers, as research has revealed in recent years ( 133 , 134 ). It has been demonstrated that circRNA has an impact on the proliferation, metastasis, stemness, angiogenesis, immune microenvironment and drug resistance of gastrointestinal tumors, and may develop into a useful therapeutic target for gastrointestinal malignancies as well as a potential biomarker ( 135 ). Although more studies have focused on the application of exosome-derived circRNAs in gastrointestinal tumors, there are still a number of problems to be solved.…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)

Xu,

Han,

Zhang

et al. 2023

Oncol Rep

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Gastrointestinal cancer is frequently detected at an advanced stage and has an undesirable prognosis due to the absence of efficient and precise biomarkers and therapeutic targets. Exosomes are small, living-cell-derived vesicles that serve a critical role in facilitating intercellular communication by transporting molecules from donor cells to receiver cells. circular RNAs (circRNAs) are mis-expressed in a variety of diseases, including gastrointestinal cancer, and are promising as diagnostic biomarkers and tumor therapeutic targets for gastrointestinal cancer. The main features of exosomes and circRNAs are discussed in the present review, along with research on the biological function of exosomal circRNAs in the development and progression of gastrointestinal cancer. It also assesses the advantages and disadvantages of implementing these findings in clinical applications.

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Exosomal circRNA: emerging insights into cancer progression and clinical application potential

Cited by 62 publications

References 190 publications

Prospects of liquid biopsy in the prognosis and clinical management of gastrointestinal cancers

Prospects of liquid biopsy in the prognosis and clinical management of gastrointestinal cancers

The role of exosomes in cancer‐related programmed cell death

Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review)

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