Exosomal circular RNAs in glioma: coexistence of opportunities and challenges for application

Chen, Jinyuan; Chen, Yue; You, Hua; Lin, Yuanxiang; Wu, Zanyi; Kang, Dezhi; Ding, Chenyu

doi:10.1097/cm9.0000000000002088

Cited by 2 publications

(2 citation statements)

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“…Most circRNAs are formed by circularization of exon sequences, and only a few circRNAs are formed from introns [ 144 ]. Most circRNAs are localized in the cytoplasm and some in the nucleus, but of growing interest is their transport through extracellular vesicles (EVs) that are secreted by various cell types [ 144 , 158 ]. EVs have already gained considerable interest in tumor research, and in relation to gliomas, EVs have been shown to contribute to tumor growth in many different ways, mainly by transporting proteins and ncRNAs [ 152 , 153 , 154 , 155 , 156 , 157 ].…”

Section: Discussionmentioning

confidence: 99%

“…This is also true for circRNAs that are contained in extracellular vesicles such as exosomes, as these circRNAs appear to exert important functions with respect to their own regulatory role within the specific tumor type and signaling pathway. Together with advances in EV sampling methods, circRNAs transported by EVs may serve as important biomarkers for gliomas [ 158 ]. Indeed, the competitive relationship between the different types of ncRNAs has been confirmed, as had the direct influence of individual ncRNAs on signaling pathways such as an EGFR-independent activation of epidermal growth factor (EGF) by a circular RNA called “circ-E-Cad” overexpressed in glioblastomas [ 159 ].…”

Section: Discussionmentioning

confidence: 99%

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The Spectrum of Molecular Pathways in Gliomas—An Up-to-Date Review

Nafe

Hattingen

2023

Biomedicines

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During the last 20 years, molecular alterations have gained increasing significance in the diagnosis and biological assessment of tumors. Gliomas represent the largest group of tumors of the central nervous system, and the main aim of this review is to present the current knowledge on molecular pathways and their alterations in gliomas. A wide range of new insights has been gained, including evidence for the involvement of the WNT pathway or the hippo pathway in the pathobiology of gliomas, indicating a broad involvement of different pathways formerly not considered to play a central role in gliomas. Even new aspects of angiogenic, apoptotic, and metabolic pathways are presented, as well as the rapidly growing field of epigenetic processes, including non-coding RNAs. The two major conclusions drawn from the present review are the distinct interconnectivity of the whole spectrum of molecular pathways and the prominent role of non-coding RNAs, especially circular RNAs, in the regulation of specific targets. All these new insights are discussed, even considering the topic of the resistance to therapy of gliomas, along with aspects that are still incompletely understood, like the role of hydroxymethylation, or even ferroptosis, in the pathobiology of gliomas.

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