Exosomal HOTAIR promotes proliferation, migration and invasion of lung cancer by sponging miR-203

Zhang, Chengcheng; Xu, Lisha; Deng, Guoying; Ding, Yuchuan; Bi, Ke; Jin, Hongbin; Shu, Jixin; Jia, Yongsheng; Deng, Haibin; Wang, Zhongqi; Wang, Yin

doi:10.1007/s11427-019-1579-x

Cited by 25 publications

(25 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Wang et al (89) demonstrated that HOTAIR is significantly associated with clinical parameters of laryngeal squamous cell carcinoma (LSCC), suggesting its potential as a valuable biomarker for screening LSCC and a promising predictive tool for patients with LSCC patients. Similar results have been reported in lung cancer, stomach cancer and liver cancer (90)(91)(92)(93). In summary, HOTAIR functions as follows: i) Promotes epigenetic activation/repression of tumour suppressor gene function, ii) affects the inhibition of target gene expression by competitively binding miRNA and iii) modifies genes to ensure their compatibility with transcription factors, while ribosomes can post-transcriptionally interact with splicing factors (30).…”

Section: Prospects and Challengessupporting

confidence: 79%

The HOTAIR lncRNA: A remarkable oncogenic promoter in human cancer metastasis (Review)

et al. 2021

Self Cite

View full text Add to dashboard Cite

Long non-coding RNA (lncRNA) is a new type of non-coding RNA that has an important regulatory influence on several human diseases, including cancer metastasis. HOX antisense intergenic RNA (HOTAIR), a newly discovered lncRNA, has an important effect on tumour proliferation, migration and metastasis. HOTAIR regulates cell proliferation, changes gene expression, and promotes tumour cell invasion and migration. However, its molecular mechanism of action remains unknown. The present review summarizes the molecular mechanism and role of HOTAIR in tumour invasion and metastasis, discusses the association between HOTAIR and tumour metastasis through different pathways, such as the transforming growth factor β, Wnt/β-catenin, PI3K/AKT/MAPK and vascular endothelial growth factor pathways, emphasizes the function of HOTAIR in human malignant tumour metastasis and provides a foundation for its application in the diagnosis, prognosis and medical treatment of various tumours.

show abstract

Section: Prospects and Challengessupporting

confidence: 79%

The HOTAIR lncRNA: A remarkable oncogenic promoter in human cancer metastasis (Review)

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Exosomal HOTAIR was first identified from serum of patients with glioblastoma multiforme ( 136 ), and then it was found to be highly expressed in bronchoalveolar lavage (BAL) of smokers, NSCLC, and healthy patients ( 137 ). NSCLC cell-derived exosomal HOTAIR promoted cancer cell proliferation, migration, and invasion by sequestrating miRNA-203 ( 138 ). Unlike the above lncRNAs, exosomal MRPL23 antisense RNA 1 (MRPL23-AS1) derived from salivary adenoid cystic carcinoma (SACC), which increased microvascular permeability and promoted the metastasis of SACC to the lungs ( 139 ).…”

Section: Exosome-derived Lncrnas In Lung Cancer Progressmentioning

confidence: 99%

Exosome-Derived LncRNAs in Lung Cancer

Fan

Sun

2020

Front. Oncol.

View full text Add to dashboard Cite

As extracellular vesicles, exosomes are released from most cells to perform cell-cell communication. Recent studies have shown that exosomes could be released into tumor microenvironment and blood to promote tumor progression through packaging and transmitting various bioactive molecules, such as cholesterol, proteins, lipids, miRNAs, mRNAs, and long non-coding RNAs (lncRNAs) to distant cells. LncRNAs have emerged as a major class of non-coding transcripts. A lot of LncRNAs have been discovered during the past few years of research on genomics. They have been proven to participate in various biological functions and disease processes through multiple mechanisms. In this review, we analyzed the role of exosome-derived lncRNAs in lung carcinogenesis and metastasis. We also highlight opportunities for the clinical potential of exosomes with specific lncRNAs as biomarkers and therapeutic intervention in lung cancer.

show abstract

“…The focus of the present study was the lncRNA HOTAIR, which has been extensively investigated (40). Accumulating evidence suggests that abnormal expression of HOTAIR is implicated in cancer development, including lung and gastric cancer, as well as hepatocellular carcinoma (41)(42)(43). Zhang et al (41) reported that HOTAIR promoted cell viability, migration and invasion.…”

Section: Discussionmentioning

confidence: 96%

“…Accumulating evidence suggests that abnormal expression of HOTAIR is implicated in cancer development, including lung and gastric cancer, as well as hepatocellular carcinoma (41)(42)(43). Zhang et al (41) reported that HOTAIR promoted cell viability, migration and invasion. Gao et al (43) demonstrated that reduced HOTAIR expression decreased hepatocellular carcinoma growth.…”

Section: Discussionmentioning

confidence: 99%

Role of the long non‑coding RNA HOTAIR/miR‑126 axis in an in vitro psoriasis model

Zha

Guo²,

Chen

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

Psoriasis is a T-cell-mediated inflammatory skin disease that is characterized by excessive keratinocyte proliferation and persistent skin inflammation. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are dysregulated in a number of inflammatory conditions. In the present study, an in vitro psoriasis cell model was established. Human HaCaT keratinocytes were activated using the inflammatory factor IL-22. Briefly, HaCaT cells were starved in serum-free DMEM for 24 h and then stimulated with 100 ng/ml IL-22 in serum-free DMEM for 24 h. Previous research indicated that HOX transcript antisense RNA (HOTAIR) may participate in the development of psoriasis. First, reverse transcription-quantitative PCR (RT-qPCR) analysis was performed to detect HOTAIR expression. The results indicated that HOTAIR expression was reduced in IL-22-stimulated HaCaT cells. Subsequently, a dual-luciferase reporter assay was performed to verify the binding site between HOTAIR and microRNA (miR)-126. The RT-qPCR results indicated that miR-126 expression was increased in IL-22-stimulated HaCaT cells. Moreover, the effects of HOTAIR and miR-126 on IL-22-stimulated HaCaT cell proliferation and apoptosis were assessed. HaCaT cells were transfected with control-plasmid, HOTAIR-plasmid, HOTAIR-plasmid + mimic control or HOTAIR-plasmid + miR-126 mimic for 24 h. At 24 h post-transfection, the cells were stimulated with 100 ng/ml IL-22 for 24 h and experiments were conducted. IL-22 induced cell proliferation and suppressed apoptosis. However, HOTAIR-plasmid inhibited cell viability and induced apoptosis in IL-22-stimulated HaCaT cells. In addition, the western blotting results indicated that HOTAIR-plasmid increased cleaved caspase-3 expression and the cleaved caspase-3/caspase-3 ratio, whereas the HOTAIR-plasmid-mediated effects were reversed by miR-126 mimic. Collectively, the results of the present study demonstrated that the lncRNA-HOTAIR/miR-126 axis may be implicated in the regulation of psoriasis progression and may serve as a potential therapeutic target for psoriasis.

show abstract

Exosomal HOTAIR promotes proliferation, migration and invasion of lung cancer by sponging miR-203

Cited by 25 publications

References 9 publications

The HOTAIR lncRNA: A remarkable oncogenic promoter in human cancer metastasis (Review)

The HOTAIR lncRNA: A remarkable oncogenic promoter in human cancer metastasis (Review)

Exosome-Derived LncRNAs in Lung Cancer

Role of the long non‑coding RNA HOTAIR/miR‑126 axis in an in vitro psoriasis model

Contact Info

Product

Resources

About