Exosomal hsa_circ_0000519 modulates the NSCLC cell growth and metastasis via miR-1258/RHOV axis

Wang, Rui; Liu, Hongliu; Dong, Mingqiang; Huang, Dan; Yi, Jun Koo

doi:10.1515/med-2022-0428

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…The RHOV gene encodes a protein that may play a crucial role in the development and metastasis of lung cancer. The expression of the RHOV gene increases in the NSCLC ( Wang R. et al, 2022 ). Zhang et al (2021) suggested that the RHOV gene might influence the progression of lung adenocarcinoma by activating the JNK/c-Jun signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

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Intratumor microbiome derived glycolysis-lactate signatures depicts immune heterogeneity in lung adenocarcinoma by integration of microbiomic, transcriptomic, proteomic and single-cell data

Deng,

Chen,

Luo

et al. 2023

Front. Microbiol.

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IntroductionMicrobiome plays roles in lung adenocarcinoma (LUAD) development and anti-tumor treatment efficacy. Aberrant glycolysis in tumor might promote lactate production that alter tumor microenvironment, affecting microbiome, cancer cells and immune cells. We aimed to construct intratumor microbiome score to predict prognosis of LUAD patients and thoroughly investigate glycolysis and lactate signature’s association with LUAD immune cell infiltration.MethodsThe Cancer Genome Atlas-LUAD (TCGA-LUAD) microbiome data was downloaded from cBioPortal and analyzed to examine its association with overall survival to create a prognostic scoring model. Gene Set Enrichment Analysis (GSEA) was used to find each group’s major mechanisms involved. Our study then investigated the glycolysis and lactate pattern in LUAD patients based on 19 genes, which were correlated with the tumor microenvironment (TME) phenotypes and immunotherapy outcomes. We developed a glycolysis-lactate risk score and signature to accurately predict TME phenotypes, prognosis, and response to immunotherapy.ResultsUsing the univariate Cox regression analysis, the abundance of 38 genera were identified with prognostic values and a lung-resident microbial score (LMS) was then developed from the TCGA-LUAD-microbiome dataset. Glycolysis hallmark pathway was significantly enriched in high-LMS group and three distinct glycolysis-lactate patterns were generated. Patients in Cluster1 exhibited unfavorable outcomes and might be insensitive to immunotherapy. Glycolysis-lactate score was constructed for predicting prognosis with high accuracy and validated in external cohorts. Gene signature was developed and this signature was elevated in epithelial cells especially in tumor mass on single-cell level. Finally, we found that the glycolysis-lactate signature levels were consistent with the malignancy of histological subtypes.DiscussionOur study demonstrated that an 18-microbe prognostic score and a 19-gene glycolysis-lactate signature for predicting prognosis of LUAD patients. Our LMS, glycolysis-lactate score and glycolysis-lactate signature have potential roles in precision therapy of LUAD patients.

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Section: Discussionmentioning

confidence: 99%

“…The expression of the RHOV gene increases in the NSCLC (Wang R. et al, 2022). Zhang et al (2021) suggested that the RHOV gene might influence the progression of lung adenocarcinoma by activating the JNK/c-Jun signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Intratumor microbiome derived glycolysis-lactate signatures depicts immune heterogeneity in lung adenocarcinoma by integration of microbiomic, transcriptomic, proteomic and single-cell data

Deng,

Chen,

Luo

et al. 2023

Front. Microbiol.

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“…A worse prognosis is related to reduced expression of circLARP4 in NSCLC. Moreover, the capacity for SPCA1 cells to metastasize is inhibited by overexpression of the circLARP4 gene [ 118 ]. Another circRNA down-regulated in NSCLC that may prevent lymphatic metastasis is hsa_circ_0033155.…”

Section: Implication Of Exosomal Circrna In Lung Cancer Progressionmentioning

confidence: 99%

Exosomal circular RNA: a signature for lung cancer progression

et al. 2022

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Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous RNAs that do not code for proteins and can create continuous and covalently closed loops. In cancer pathogenesis, especially metastasis, exosomal circRNAs (exo-circRNAs) have a crucial role mainly due to the frequently aberrant expression levels within tumors. However, neither the activities nor the regulatory mechanisms of exo-circRNAs in advancing lung cancer (LC) are obvious. A better understanding of the regulation and network connections of exo-circRNAs will lead to better treatment for LCs. The main objective of the current review is to highlight the functions and mechanisms of exo-circRNAs in LC and assess the relationships between exo-circRNA dysregulation and LC progression. In addition, underline the possible therapeutic targets based on exo-circRNA modulating.

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“…In addition to the factors mentioned above, we have summarized others derived from exosomes can serve as the potential regulators for EMT [20–24] and proliferation, migration and invasion [25–27,28 ▪ ,29–38,39 ▪▪ ,42] (Table 1).…”

Section: Tumour-derived Exosomes Promote Metastasis Through Regulatio...mentioning

confidence: 99%

The role and underlying mechanisms of tumour-derived exosomes in lung cancer metastasis

Yang

Zhou

et al. 2022

Current Opinion in Oncology

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Purpose of reviewLung cancer is one of the most common malignant tumours worldwide. Metastasis is a serious influencing factor for poor treatment effect and shortened survival in lung cancer. But the complicated underlying molecular mechanisms of tumour metastasis remain unclear. In this review, we aim to further summarize and explore the underlying mechanisms of tumour-derived exosomes (TDEs) in lung cancer metastasis.Recent findingsTDEs are actively produced and released by tumour cells and carry messages from tumour cells to normal or abnormal cells residing at close or distant sites. Many studies have shown that TDEs promote lung cancer metastasis and development through multiple mechanisms, including epithelial-mesenchymal transition, immunosuppression and the formation of a premetastatic niche. TDEs regulate these mechanisms to promote metastasis by carrying DNA, proteins, miRNA, mRNA, lncRNA and ceRNA. Further exploring TDEs related to metastasis may be a promising treatment strategy and deserve further investigation.SummaryOverall, TDEs play a critical role in metastatic of lung cancer. Further studies are needed to explore the underlying mechanisms of TDEs in lung cancer metastasis.

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Exosomal hsa_circ_0000519 modulates the NSCLC cell growth and metastasis via miR-1258/RHOV axis

Cited by 8 publications

References 34 publications

Intratumor microbiome derived glycolysis-lactate signatures depicts immune heterogeneity in lung adenocarcinoma by integration of microbiomic, transcriptomic, proteomic and single-cell data

Intratumor microbiome derived glycolysis-lactate signatures depicts immune heterogeneity in lung adenocarcinoma by integration of microbiomic, transcriptomic, proteomic and single-cell data

Exosomal circular RNA: a signature for lung cancer progression

The role and underlying mechanisms of tumour-derived exosomes in lung cancer metastasis

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